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Publication
ID32088543Published Date2020-04-01JournalEnvironment international, 2020-04-01, Volume 137
The relationship of plasma concentration of per- and polyfluoroalkyl substances (PFAS) with blood pressure (BP) is uncertain. This study examined cross-sectional and prospective associations of PFAS with BP and hypertension. We quantified plasma PFAS concentrations from 957 participants enrolled in the lifestyle and placebo arms of the Diabetes Prevention Program (DPP), a randomized controlled trial with approximately 15 years of follow-up. We used multivariable linear and logistic regression…
Publication
ID32086073Published Date2020-04-01JournalEnvironment international, 2020-04-01, Volume 137
Diet is assumed to be the main source of exposure to per- and polyfluoroalkyl substances (PFAS) in non-occupationally exposed populations, but studies on the diet-PFAS relationship in the United States are scarce. We extracted multiple dietary variables, including daily intakes of food group, diet scores, and dietary patterns, from self-reported dietary data collected at baseline (1996-1999) from adults with pre-diabetes enrolled in the Diabetes Prevention Program, and used linear regression …
Publication
ID31714583Published Date2020-04-01JournalThe Journal of clinical endocrinology and metabolism, 2020-04-01, Volume 105
Postbariatric hypoglycemia (PBH) can threaten safety and reduce quality of life. Current therapies are incompletely effective.Patients with PBH were enrolled in a double-blind, placebo-controlled, crossover trial to evaluate a closed-loop glucose-responsive automated glucagon delivery system designed to reduce severe hypoglycemia. A hypoglycemia detection and mitigation algorithm was embedded in the artificial pancreas system connected to a continuous glucose monitor (CGM, Dexcom) driving a p…
Publication
ID32188983Published Date2020-03-19JournalThe Journal of clinical endocrinology and metabolism, 2020-03-19
The rising prevalence of endocrine disorders over the past two decades -primarily driven by chronic conditions like diabetes- has resulted in a shortage of adult endocrinologists. Despite the wide gap between workforce supply and clinical care demand, a career in endocrinology is not viewed as an attractive choice for internal medicine (IM) residents. Indeed, the number of applicants to endocrinology training programs relative to available positions has declined since 2008, and endocrinology …
Publication
ID32184391Published Date2020-03-17JournalNature communications, 2020-03-17, Volume 11
Uncoupling protein-1 (UCP1) plays a central role in energy dissipation in brown adipose tissue (BAT). Using high-throughput library screening of secreted peptides, we identify two fibroblast growth factors (FGF), FGF6 and FGF9, as potent inducers of UCP1 expression in adipocytes and preadipocytes. Surprisingly, this occurs through a mechanism independent of adipogenesis and involves FGF receptor-3 (FGFR3), prostaglandin-E2 and interaction between estrogen receptor-related alpha, flightless-1 …
Publication
ID32175731Published Date2020-03-16JournalJournal of the American Chemical Society, 2020-03-16
The loss of insulin-producing β-cells is the central pathological event in type 1 and 2 diabetes, which has led to efforts to identify molecules to promote β-cell proliferation, protection, and imaging. However, the lack of β-cell specificity of these molecules jeopardizes their therapeutic potential. A general platform for selective release of small-molecule cargoes in β-cells over other islet cells or other cell-types in an organismal context will be immensely valuable in advancing diabetes…
Publication
ID31776080Published Date2020-03-15JournalJournal of hazardous materials, 2020-03-15, Volume 386
Although in-vivo exposure of PM has been suggested to initiate a disorder on vascular permeability, the effects and related mechanism has not been well defined. In this work, an obvious increase on vascular permeability has been confirmed in vivo by vein injection of PM into Balb/c mouse. Human umbilical vein vascular endothelial cells and the consisted ex-vivo vascular endothelium were used as model to investigate the effects of PM on the vascular permeability and the underlying molecular me…
Publication
ID32077755Published Date2020-03-10JournalDiabetes technology & therapeutics, 2020-03-10
There are multiple information sources available to assist families in learning about rapidly advancing diabetes technologies as care options for their children. This study explored where and from whom families of young children with type 1 diabetes get information about diabetes technologies and the valence (positive vs. negative) of that information. Semi-structured interviews were conducted with parents (86% mothers) of 79 youth
Publication
ID32156724Published Date2020-03-10JournalProceedings of the National Academy of Sciences of the United States of America, 2020-03-10
Insulin action in the liver is critical for glucose homeostasis through regulation of glycogen synthesis and glucose output. Arrestin domain-containing 3 () is a member of the α-arrestin family previously linked to human obesity. Here, we show that is differentially regulated by insulin in vivo in mice undergoing euglycemic-hyperinsulinemic clamps, being highly up-regulated in liver and down-regulated in muscle and fat. Mice with liver-specific knockout (KO) of the insulin receptor (IR) have …
Publication
ID30423026Published Date2020-03-09JournalThe journals of gerontology. Series A, Biological sciences and medical sciences, 2020-03-09, Volume 75
Nuclear factor (NF)κB is a transcription factor that controls immune and inflammatory signaling pathways. In skeletal muscle, NFκB has been implicated in the regulation of metabolic processes and tissue mass, yet its affects on mitochondrial function in this tissue are unclear. To investigate the role of NFκB on mitochondrial function and its relationship with muscle mass across the life span, we study a mouse model with muscle-specific NFκB suppression (muscle-specific IκBα super-repressor […
We found 6,013 documents that match your Search
Research Grants: 1,808
Publications: 3,402
Patents: 351
Clinical Trials: 157
Web Documents: 295

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