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Research Grant
Project Number5R21AI146703-02Funding AgencyNational Institutes of HealthEffective Date2020-06-01Expiration Date2021-05-31Funding Amount$268,375
Abstract Multi-drug resistant TB (MDR-TB) is caused by Mycobacterium tuberculosis (Mtb) strains that are resistant to two front-line antibiotics, isoniazid (INH) and rifampin (RIF), in the recommended TB treatment regimen. The World Health Organization (WHO) estimates the prevalence of MDR-TB at approximately 50 million people worldwide, expanding by nearly 500,000 new cases each year. A more alarming development is the increase in and global distribution of extremely drug- resistant TB (XDR-…
Patent
Publication NumberUS 20200163922Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-05-17Publication Date2020-05-28
Provided herein are compositions comprising a resolvin mimetic. Such mimetics may comprise an anti-ERV1 antibody, such as a resolvimab, or biologically-active antibody fragment thereof. Also provided herein are methods for treating or preventing an inflammatory disorder in a subject in need thereof comprising the steps of administering a therapeutically effective amount of at least one resolvin mimetic.
Publication
ID31754744Published Date2020-05-01JournalMicrobial ecology, 2020-05-01, Volume 79
Prophylactic or therapeutic antibiotic use along with chemotherapy treatment potentially has a long-standing adverse effect on the resident gut microbiota. We have established a case-control cohort of 32 pediatric and adolescent acute lymphoblastic leukemia (ALL) patients and 25 healthy siblings (sibling controls) to assess the effect of chemotherapy as well as antibiotic prophylaxis on the gut microbiota. We observe that the microbiota diversity and richness of the ALL group is significantly…
Research Grant
Project Number5R01DK112381-03Funding AgencyNational Institutes of HealthEffective Date2020-04-01Expiration Date2021-03-31Funding Amount$313,952
Evidence suggests that lifestyle changes, concordant with the adoption of agriculture and industrialization, have impacted the emergence of the so-called diseases of modern civilization in humans (e.g. metabolic disorders, cardiovascular disease etc.). The incidence of these diseases in contemporary, industrialized populations is believed to be associated with a lack of adaptation of our genomes to the rapid dietary and lifestyle changes that occurred across human evolution. However the usefu…
Research Grant
Project Number5R21DE028609-02Funding AgencyNational Institutes of HealthEffective Date2020-04-01Expiration Date2021-03-31Funding Amount$292,500
Project Summary Dental caries is the most common chronic disease, globally, is associated with a tremendous economic burden, and disproportionally affects populations least able to access dental care and afford treatment. Streptococcus mutans (Smu) is a common constituent of dental plaque, and the primary etiologic agent of dental caries. Smu causes disease by forming robust biofilms on the tooth surface and producing organic acids which dissolve the underlying tooth enamel. To persist in the…
Research Grant
Project Number1R21AI151730-01Funding AgencyNational Institutes of HealthEffective Date2020-03-01Expiration Date2021-02-28Funding Amount$330,390
PROJECT SUMMARY The emergence and transmission of antimicrobial resistance (AMR) is currently one of the most critical public health threats. As such there is an urgent need to identify new ways to reduce AMR transmission. In recent years, several studies have started to reveal the complex relations and interactions between antibiotics, antimicrobial resistance genes (ARGs) and the human microbiome. The human microbiome plays profound roles in responding to antibiotic treatment and the transm…
Publication
ID32064741Published Date2020-02-16JournalAddiction biology, 2020-02-16
Eating disorders and substance use disorders frequently co-occur. Twin studies reveal shared genetic variance between liabilities to eating disorders and substance use, with the strongest associations between symptoms of bulimia nervosa and problem alcohol use (genetic correlation [r ], twin-based = 0.23-0.53). We estimated the genetic correlation between eating disorder and substance use and disorder phenotypes using data from genome-wide association studies (GWAS). Four eating disorder phen…
Research Grant
Project Number5R01ES030227-02Funding AgencyNational Institutes of HealthEffective Date2020-02-01Expiration Date2021-01-31Funding Amount$676,635
Asthma is triggered or worsened by environmental exposures and is associated with epigenetic changes in humans and animal models. Microbial dysbiosis in the gut and the lung is increasingly being associated with the incidence and severity of asthma, however causality studies are lacking. We have adapted a mouse model that focuses on the ONSET of allergic asthma early in life after an in utero exposure to environmental particles to study how microbiome may lead to the asthma onset. In this mod…
Research Grant
Project Number1R21AI149448-01Funding AgencyNational Institutes of HealthEffective Date2020-01-27Expiration Date2020-12-31Funding Amount$243,750
While tools to manipulate viral nucleic acids have improved rapidly, methods to rescue infectious virus from genomic material that is not infectious have not. Methods for virus rescue are available for increasing numbers of virus species but must be individually developed and optimized for each different group of related viruses?a process that is time-consuming and costly. Therefore, there is a need to develop a generalizable synthetic genomics technology to facilitate rapid rescue of broad r…
Publication
IDCSHL:2020.01.23.909457Published Date2020-01-24JournalbioRxiv, 2020-01-24
Duckweeds are a monophyletic group of rapidly reproducing aquatic monocots in the Lemnaceae family. Spirodela polyrhiza, the Greater Duckweed, has the largest body plan yet the smallest genome size in the family (1C = 150 Mb). Given their clonal, exponentially fast reproduction, a key question is whether genome structure is conserved across the species in the absence of meiotic recombination. We generated a highly contiguous, chromosome-scale assembly of Spirodela polyrhiza line Sp7498 using …
We found 472 documents that match your Search
Research Grants: 297
Publications: 30
Patents: 139
Clinical Trials: 6

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