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Patent
Publication NumberUS 10293056Filing StatusIssued PatentAvailabilityUnknownFiling Date2000-05-24Publication Date2019-05-21
The present invention relates to non-viral gene therapy methods and compositions for treatment of hyperproliferative disease in humans. More specifically, the invention is directed, in one embodiment, to lipid formulations which form stable liposome structures, capable of efficient in vivo nucleic acid transfer. In other embodiments, methods and compositions are directed to liposome transfer of anti-proliferative nucleic acids, wherein the transfer of the nucleic acids is cell specific via ce…
Patent
Publication NumberUS 9428768Filing StatusIssued PatentAvailabilityUnknownFiling Date2009-10-28Publication Date2016-08-30
The present invention relates to improved methods for producing adenovirus compositions wherein host cells are grown in a bioreactor and purified by size partitioning purification to provide purified adenovirus compositions.
Patent
Publication NumberCA 2429769 CFiling StatusIssued PatentAvailabilityUnknownFiling Date2001-12-07Publication Date2016-04-26
The present invention relates to gene therapy methods for the treatment of human disease. More specifically, the invention is directed to methods for treating a subject with an angiogenesis-related disease. In one embodiment, an adenoviral expression construct comprising a nucleic acid encoding a human MDA-7 protein under the control of a promoter operable in eukaryotic cells, is administered to said patient with a angiogenesis-related disease. The present invention thus provides for treatmen…
Patent
Publication NumberCA 2518150 CFiling StatusIssued PatentAvailabilityUnknownFiling Date2004-03-02Publication Date2015-08-11
The present invention relates to compositions and methods involving MDA-7. More specifically, the present invention is directed to diagnostic, prognostic, and therapeutic treatment compositions and methods for treatment of cancer and other angiogenesis-related disorders (anti-angiogenesis therapy). The present invention is also directed to methods of purification of MDA-7.
Patent
Publication NumberCA 2350890 CFiling StatusIssued PatentAvailabilityUnknownFiling Date1999-11-16Publication Date2014-07-08
The present invention addresses the need to improve the long-term storage stability (i.e. infectivity) of vector formulations. In particular, it has been demonstrated that for adenovirus, the use of bulking agents, cryoprotectants and lyoprotectants imparts desired properties that allow both lyophilized and liquid adenovirus formulations to be stored at 4~C for up to 6 months and retain an infectivity between 60-100% of the starting infectivity.
Patent
Publication NumberUS 8668905Filing StatusIssued PatentAvailabilityLicensableFiling Date2006-05-12Publication Date2014-03-11
The present invention relates to immunotherapy methods for treating hyperproliferative disease in humans, particularly to hyperproliferative disease that is refractory to therapy. More specifically, the invention is directed, in one embodiment, to methods for treating a subject with a hyperproliferative disease in which the expression of a self gene is upregulated in therapy-resistant hyperproliferative cells. In another embodiment, an adenoviral expression construct comprising a self gene un…
Patent
Publication NumberCA 2272820 CFiling StatusIssued PatentAvailabilityUnknownFiling Date1997-11-20Publication Date2012-09-11
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of …
Patent
Publication NumberCA 2371922 CFiling StatusIssued PatentAvailabilityUnknownFiling Date2000-05-24Publication Date2012-03-27
The present invention relates to non-viral gene therapy methods and compositions for treatment of hyperproliferative disease in humans. More specifically, the invention is directed, in one embodiment, to lipid formulations which form stable liposome structures, capable of efficient in vivo nucleic acid transfer. In other embodiments, methods and compositions are directed to liposome transfer of anti-proliferative nucleic acids, wherein the transfer of the nucleic acids is cell specific via ce…
Patent
Publication NumberEP 1760151 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date1997-11-20Publication Date2012-03-21
Patent
Publication NumberCA 2353787 CFiling StatusIssued PatentAvailabilityUnknownFiling Date1999-11-16Publication Date2011-12-20
The present invention addresses the need to improve the yields of viral vectors when grown in cell culture systems. In particular, it has been demonstrated that for adenovirus, the use of low-medium perfusion rates in an attached cell culture system provides for improved yields. In other embodiments, the inventors have shown that there is improved Ad-p53 production with cells grown in serum-free conditions, and in particular in serum-free suspension culture. Also important to the increase of …
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