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Publication
PubMed ID30277459Published Date2018-10-02JournaleLife, 2018-10-02, Volume 7
Spinal cord injury (SCI) is a devastating neurological condition for which there are currently no effective treatment options to restore function. A major obstacle to the development of new therapies is our fragmentary understanding of the coordinated pathophysiological processes triggered by damage to the human spinal cord. Here, we describe a systems biology approach to integrate decades of small-scale experiments with unbiased, genome-wide gene expression from the human spinal cord, reveal…
Publication
PubMed ID29902472Published Date2018-10-01JournalArchives of physical medicine and rehabilitation, 2018-10-01, Volume 99
To assess the influence of a home-based exercise intervention on indices of health-related quality of life (HRQOL) in persons with spinal cord injury (SCI).This was a randomized controlled trial (HOMEX-SCI; ISRCTN57096451). After baseline laboratory testing and a week of free-living physical activity monitoring, eligible participants were randomly assigned (2:1 allocation ratio) to a home-based moderate-intensity upper-body exercise intervention group (INT, n=13), or a lifestyle maintenance c…
Publication
PubMed ID30195218Published Date2018-10-01JournalGait & posture, 2018-10-01, Volume 66
As the proportion of older adults in the population increases, so does the associated prevalence of falls, making falls the leading cause of fatal and nonfatal injuries among adults aged ≥65 years. In response, researchers and clinicians seek to develop a clinical tool that accurately predicts fall risk. These Investigations have included measures of clinical mobility and balance tests, strength, physiologically based tests, postural sway, and mean and variability of gait measures. To date, n…
Publication
PubMed ID29882712Published Date2018-10-01JournalJournal of medical economics, 2018-10-01, Volume 21
Intermittent catheterization (IC) is the gold standard for bladder management in patients with chronic urinary retention. Despite its medical benefits, IC users experience a negative impact on their quality of life (QoL). For health economics based decision making, this impact is normally measured using generic QoL measures (such as EQ-5D) that estimate a single utility score which can be used to calculate quality-adjusted life years (QALYs). But these generic measures may not be sensitive to…
Publication
PubMed ID29920232Published Date2018-10-01JournalArchives of physical medicine and rehabilitation, 2018-10-01, Volume 99
To assess the feasibility of measuring ventilatory threshold (VT) in higher-level motor-complete spinal cord injury (SCI) using 4 different analysis methods based on noninvasive gas exchange.Observational.Laboratory testing.Individuals with C4-T6 motor-complete SCI (16 paraplegia, 22 tetraplegia; American Spinal Injury Association Impairment Scale A/B; 42±10 years old).Not applicable.VT from a graded arm cycling test to volitional exhaustion using 4 methods: ventilatory equivalents, excess CO…
Publication
PubMed ID30273077Published Date2018-10-01JournalDisability and rehabilitation, 2018-10-01
To (1) evaluate the level of agreement between individually calibrated accelerometers and the self-reported Physical Activity Recall Assessment for People with Spinal Cord Injury when assessing moderate-vigorous physical activity; and (2) qualitatively examine the different components of physical activity each measure assesses.Nineteen manual wheelchair users with chronic spinal cord injury (19.0 ± 12.9 years post injury, C5-L2 injury level) wore a wrist and spoke accelerometer for one week t…
Publication
PubMed ID30262456Published Date2018-09-27JournalHeart (British Cardiac Society), 2018-09-27
Conduct a meta-analysis to determine the impact of traumatic spinal cord injury (SCI) on echocardiographic measurements of left ventricular (LV) structure and function.MEDLINE and Embase were used for primary searches of studies reporting LV echocardiographic data in individuals with SCI. Of 378 unique citations, 36 relevant full-text articles were retrieved, and data from 27 studies were extracted for meta-analyses. Literature searches, article screening and data extraction were completed by…
Publication
PubMed ID30268805Published Date2018-09-27JournalArchives of physical medicine and rehabilitation, 2018-09-27
To create a parsimonious, psychometrically-sound measure of experiential aspects of participation (MeEAP) for people with physical disabilities.Cross-sectional.Online survey PARTICIPANTS: Respondents were a purposive sample of 228 adults (n = 118 female, M = 49.66, SD = 14.71, Range = 19-83). Each respondent indicated having a physical disability and participating in employment, mobility, sport, and/or exercise life domains.None.The MeEAP was designed to be conceptually aligned with six exper…
Publication
PubMed ID30158159Published Date2018-09-25JournalNeurology, 2018-09-25, Volume 91
To systematically examine the incidence of cognitive impairment in individuals with spinal cord injury (SCI), as well as identify potential contributing and confounding factors.Studies quantitatively reporting cognitive ability after spinal cord injury were searched electronically via Medline, CINAHL, Embase, and PsycINFO. Manual screening for references within articles was also performed. A total of 2,481 studies were screened and a total of 70 were included in this review, 21 reporting cogn…
Publication
PubMed ID30240805Published Date2018-09-19JournalJournal of neuroscience methods, 2018-09-19
Imaging measurement of structure alignment has shown increasing importance in determining tissue properties. It is not known if a similar ability for characterizing neuropathology exists.This study aimed to validate a new alignment-assessing method for measuring myelin and axonal properties using quantitative histological metrics. The new method involved analysis of the Fourier transform (FT) power spectrum in standard magnetic resonance imaging (MRI). T-weighted MRI were collected from 10 po…
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Publications: 346
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