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ID32203125Published Date2020-07-01JournalThe Journal of antibiotics, 2020-07-01, Volume 73
Microbial-derived natural products provide unique bioactivities and serve as a unique source of drug leads. In the present study, we isolated one new chresdihydrochalcone (1), one new chresphenylacetone (2), and one known streptimidone (3) from Streptomyces chrestomyceticus BCC 24770 using antibacterial activity-guided isolation and purification procedures. We determined their molecular weights using MS and HRMS and elucidated their chemical structures from their 1D and 2D NMR and electronic …
Publication
ID32548680Published Date2020-07-01JournalScience China. Life sciences, 2020-07-01, Volume 63
Cells are compartmentalized by numerous membrane-enclosed organelles and membraneless compartments to ensure that a wide variety of cellular activities occur in a spatially and temporally controlled manner. The molecular mechanisms underlying the dynamics of membrane-bound organelles, such as their fusion and fission, vesicle-mediated trafficking and membrane contactmediated inter-organelle interactions, have been extensively characterized. However, the molecular details of the assembly and f…
Publication
ID32092239Published Date2020-07-01JournalHealth & social care in the community, 2020-07-01, Volume 28
Despite growing concern over socioeconomic inequality in health, few studies have focused on health inequality among older adults. The present study examined the independent and joint effects of socioeconomic status (SES) and family functioning on mental health and subjective well-being and explored the gender differences in such relations. Representative survey data on older adults (N = 1,432) were drawn from the third wave of the Hong Kong Panel Study of Social Dynamics conducted in 2015. D…
Publication
ID32302802Published Date2020-07-01JournalBiomaterials, 2020-07-01, Volume 248
Organic near-infrared (NIR) emitters with simultaneously high absorption coefficient and photoluminescence quantum yield (PLQY) are highly desirable for biomedical imaging yet seldom reported because these two aspects are usually contradictory. The conjugated planar structures exhibit strong absorption but the emission is seriously quenched in aggregate state, whereas the twisted unplanar molecules display opposite phenomena. Herein, we report a kind of dragonfly-shaped NIR aggregation-induce…
Publication
IDIEEE:9091334Published Date2020-07-01JournalIEEE Robotics and Automation Letters, 2020-07-01, Volume 5
All-day and all-weather navigation is a critical capability for autonomous driving, which requires proper reaction to varied environmental conditions and complex agent behaviors. Recently, with the rise of deep learning, end-to-end control for autonomous vehicles has been well studied. However, most works are solely based on visual information, which can be degraded by challenging illumination conditions such as dim light or total darkness. In addition, they usually generate and apply determi…
Publication
ID31994000Published Date2020-07-01JournalReproductive sciences (Thousand Oaks, Calif.), 2020-07-01, Volume 27
Sertoli cells are important for spermatogenesis not only by directly interacting with germ line cells in the seminiferous epithelium but also by constituting the blood-testis barrier (BTB) structure to create a favorable environment for spermatogenesis. Blind sterile (bs) male mice are infertile, with excessive germ cell apoptosis and spermatogenesis arrest. TBC1D20 (TBC1 domain family member 20) deficiency has been identified as the causative mutation in bs mice. However, whether TBC1D20 los…
Publication
IDIEEE:8651349Published Date2020-07-01JournalIEEE Transactions on Pattern Analysis and Machine Intelligence, 2020-07-01, Volume 42
Radiometrically calibrating nonlinear images from Internet photo collections makes photometric analysis applicable not only to lab data but also to big image data in the wild. However, conventional calibration methods cannot be directly applied to such photo collections. This paper presents a method to jointly perform radiometric calibration for a set of nonlinear images in Internet photo collections. By incorporating the consistency of scene reflectance of corresponding pixels across nonline…
Publication
ID32521242Published Date2020-07-01JournalTrends in ecology & evolution, 2020-07-01, Volume 35
The Belt and Road Initiative (BRI) represents the largest infrastructure and development project in human history, and presents risks and opportunities for ecosystems, economies, and communities. Some risks (habitat fragmentation, roadkill) are obvious, however, many of the BRI's largest challenges for development and conservation are not obvious and require extensive consideration to identify. In this first BRI Horizon Scan, we identify 11 frontier issues that may have large environmental an…
Publication
ID32097691Published Date2020-07-01JournalAppetite, 2020-07-01, Volume 150
Obesity is one of the greatest public health challenges of modern times and its prevalence is increasing worldwide. With food so abundant in developed countries, many people face a conflict between desires for short-term taste and the goal of long-term health, multiple times a day. Recent research suggests that consumers often resolve these conflicts based on their lay beliefs about the healthiness and tastiness of food. Consequently, such lay beliefs can play critical roles not just in food …
Publication
ID32389636Published Date2020-07-01JournalBiochemical pharmacology, 2020-07-01, Volume 177
Melatonin MT and MT receptors represent attractive drug targets for the treatment of various disorders. However, the high conservation of the melatonin binding pocket has hindered the development of subtype-selective compounds. By leveraging on the recently resolved crystal structures of MT and MT receptors, this study aims to elucidate the structural basis of MT-selectivity of a panel of isoquinolinone derivatives. Molecular modelling and ligand docking approaches were employed to predict re…
We found 13,382 documents that match your Search
Research Grants: 21
Publications: 12,537
Patents: 815
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