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ID32005519Published Date2020-04-02JournalBiochemical and biophysical research communications, 2020-04-02, Volume 524
Signaling adaptor protein Crk has been shown to play an important role in various human cancers. Crk links tyrosine kinases and guanine nucleotide exchange factors (GEFs) such as C3G and Dock180 to activate small G-proteins Rap and Rac, respectively. In pancreatic cancer, various molecular targeted therapies have provided no significant therapeutic benefit for the patients so far due to constitutive activation of KRAS by frequent KRAS mutation. Therefore, the establishment of novel molecular …
Publication
ID31669133Published Date2020-04-01JournalSeminars in cell & developmental biology, 2020-04-01, Volume 100
Liver regeneration is an important and necessary process that the liver depends on for recovery from injury. The regeneration process consists of a complex network of cells and organs, including liver cells (parenchymal and non-parenchymal cells) and extrahepatic organs (thyroid, adrenal glands, pancreas, duodenum, spleen, and autonomic nervous system). The regeneration process of a normal, healthy liver depends mainly on hepatocyte proliferation, growth, and programmed cell death. Cell proli…
Publication
ID31733925Published Date2020-04-01JournalHuman immunology, 2020-04-01, Volume 81
Human leukocyte antigen (HLA)-G, a non-classical HLA class I molecule, has one of the splicing isoforms, HLA-G2, which lacks one domain (α2) and forms a non-covalent homodimer. HLA-G2 is expressed on placental cells, regulatory T cells, tumor cells, and virus-infected cells, and is involved in immunosuppression. The major isoform of HLA-G, HLA-G1, binds to leukocyte immunoglobulin (Ig)-like receptor (LILR) B1 and LILRB2, on the contrary, HLA-G2 binds to only LILRB2. We previously reported tha…
Publication
ID31880411Published Date2020-04-01JournalAmerican journal of medical genetics. Part A, 2020-04-01, Volume 182
We present two unrelated Japanese pedigrees with achondrogenesis type 1b (ACG1B), characterized by prenatally lethal fetal hydrops and severe micromelia. The affected members in these pedigrees carried a common homozygous missense point mutation in solute carrier family 26 member 2 (SLC26A2), a gene associated with ACG1B (NM_000112:c.1987G>A). This loss-of-function point mutation causes substitution of glycine 663 with arginine in a highly conserved loop domain of SLC26A2. Interestingly, only…
Publication
ID32190322Published Date2020-04-01JournalMolecular and clinical oncology, 2020-04-01, Volume 12
The response to preoperative chemotherapy is useful for predicting prognosis in unresectable and resectable disease. However, the prognostic benefit of chemotherapy prior to hepatectomy in patients with colorectal carcinoma and resectable or marginally resectable liver metastases remains unclear. The present study investigated the effect of preoperative chemotherapy on the prognosis of patients with colorectal cancer and resectable or marginally resectable synchronous liver metastasis. A tota…
Publication
ID32036095Published Date2020-04-01JournalEcotoxicology and environmental safety, 2020-04-01, Volume 192
Mercury (Hg) is an extremely dangerous environmental contaminant, responsible for human diseases including neurological disorders. However, the mechanisms of inorganic Hg (iHg)-induced cell death and toxicity are little known. Dihydrolipoic acid (DHLA) is the reduced form of a naturally occurring compound lipoic acid, which act as a potent antioxidant through multiple mechanisms. So we hypothesized that DHLA has an inhibitory role on iHg-cytotoxicity. The purposes of this research were to inv…
Publication
ID31598751Published Date2020-04-01JournalCurrent genetics, 2020-04-01, Volume 66
Changes in gene expression via chromatin-mediated mechanisms are important for reprogramming and differentiation, but uncontrolled changes can potentially lead to harmful or adaptive phenotypic alteration. Thus, diversification of the genome-wide chromatin state must be strictly limited, but the underlying mechanism of this regulation is largely unknown. In this review, we focused on distribution of heterochromatin, a tight chromatin structure that negatively regulates gene expression. Hetero…
Publication
ID31839561Published Date2020-04-01JournalJournal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy, 2020-04-01, Volume 26
Mycobacterium leprae causes leprosy and ofloxacin is used to control this bacterium. However, specific amino acid substitutions in DNA gyrases of M. leprae interferes with the effect of ofloxacin.Here we tested the inhibitory effect of WQ-3810 on DNA gyrases in M. leprae, using recombinant gyrases. We theorized that WQ-3810 and DNA gyrases interacted, which was tested in silico. Compared with control drugs like ofloxacin, WQ-3810 showed a better inhibitory effect on ofloxacin-resistant DNA gy…
Publication
IDDOI:10.1175/jcli-d-19-0108.1Published Date2020-04-01JournalJournal of Climate, 2020-04-01, Volume 33
The fixed anvil temperature (FAT) theory describes a mechanism for how tropical anvil clouds respond to global warming and has been used to argue for a robust positive longwave cloud feedback. A constant cloud anvil temperature, due to increased anvil altitude, has been argued to lead to a “zero cloud emission change” feedback, which can be considered positive relative to the negative feedback associated with cloud anvil warming when cloud altitude is unchanged. Here, partial radiative pertur…
Publication
ID31950245Published Date2020-04-01JournalPediatric nephrology (Berlin, Germany), 2020-04-01, Volume 35
Patients with refractory nephrotic syndrome (NS) are at high risk of medication-induced glucose metabolism disorders, because of their long-term use of diabetogenic medications, particularly glucocorticoids and calcineurin inhibitors (CNIs). However, there have been no comprehensive evaluations of glucose metabolism disorders in pediatric patients with refractory NS. Moreover, glucocorticoids and CNIs could not be discontinued in these patients until the effectiveness of rituximab on refracto…
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