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Publication
ID32020839Published Date2020-02-18JournalJournal of the American Heart Association, 2020-02-18, Volume 9
Background De novo lipogenesis (DNL) is an endogenous pathway that converts excess dietary starch, sugar, protein, and alcohol into specific fatty acids (FAs). Although elevated DNL is linked to several metabolic abnormalities, little is known about how long-term habitual levels and changes in levels of FAs in the DNL pathway relate to incident heart failure (HF). Methods and Results We investigated whether habitual levels and changes in serial measures of FAs in the DNL pathway were associat…
Publication
ID31774192Published Date2020-02-20JournalStatistics in medicine, 2020-02-20, Volume 39
Covariates associated with treatment-effect heterogeneity can potentially be used to make personalized treatment recommendations towards best clinical outcomes. Methods for treatment-selection rule development that directly maximize treatment-selection benefits have attracted much interest in recent years, due to the robustness of these methods to outcome modeling. In practice, the task of treatment-selection rule development can be further complicated by missingness in data. Here, we conside…
Patent
Publication NumberUS 20200048707Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-10-18Publication Date2020-02-13
The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
Patent
Publication NumberUS 20200046775Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-10-17Publication Date2020-02-13
The present invention relates to methods, kits and compositions for expansion of embryonic hematopoietic stem cells and providing hematopoietic function to human patients in need thereof. In one aspect, it relates to kits and compositions comprising a Notch agonist, one or more growth factors, and, optionally, an inhibitor of the TGFβ pathway. Also provided herein are methods for expanding embryonic hematopoietic stem cells using kits and compositions comprising a Notch agonist, one or more g…
Patent
Publication NumberUS 20200048706Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-10-18Publication Date2020-02-13
The present disclosure provides compositions and methods for accurately detecting mutations by uniquely tagging double stranded nucleic acid molecules with dual cyphers such that sequence data obtained from a sense strand can be linked to sequence data obtained from an anti-sense strand when sequenced, for example, by massively parallel sequencing methods.
Publication
IDDOI:10.1093/cdn/nzaa021Published Date2020-02-12JournalCurrent Developments in Nutrition, 2020-02-12
Abstract Background Women without cardiovascular disease (CVD) or hypertension at baseline assigned to intervention in the Women's Health Initiative Dietary Modification (DM) trial experienced 30% lower risk of coronary heart disease (CHD), while results among women with hypertension or prior CVD may have been confounded by post-randomization use of statins. Objective Intervention participants reported various self-selected changes to achieve the 20% total fat goals. Reviewed are intervention…
Publication
ID31974303Published Date2020-02-11JournalProceedings of the National Academy of Sciences of the United States of America, 2020-02-11, Volume 117
Viruses transmitted by mosquitoes, such as dengue, Zika, and chikungunya, have expanding ranges and seem unabated by current vector control programs. Effective control of these pathogens likely requires integrated approaches. We evaluated dengue management options in an endemic setting that combine novel vector control and vaccination using an agent-based model for Yucatán, Mexico, fit to 37 y of data. Our intervention models are informed by targeted indoor residual spraying (TIRS) experiment…
Publication
ID31797425Published Date2020-02-10JournalStatistics in medicine, 2020-02-10, Volume 39
Disease surveillance systems provide a rich source of data regarding infectious diseases, aggregated across geographical regions. The analysis of such ecological data is fraught with difficulties, and, unless care and suitable data summaries are available, will lead to biased estimates of individual-level parameters. We consider using surveillance data to study the impacts of vaccination. To catalog the problems of ecological inference, we start with an individual-level model, which contains …
Publication
IDDOI:10.1200/jco.2020.38.5_suppl.14Published Date2020-02-10JournalJournal of Clinical Oncology, 2020-02-10, Volume 38
14 Background: ICOS is a costimulatory molecule upregulated on activated T cells. Vopra is an investigational ICOS agonist antibody that results in activation and proliferation of primed CD4 T effector cells. Vopra was assessed in heavily pretreated patients with advanced solid tumors as monotherapy (mono) or in combination with nivolumab (nivo) in the Phase 1/2 ICONIC trial (NCT02904226). Emergence of a distinct ICOS high (hi) population of peripheral CD4 T effector cells, not seen with PD-1…
Publication
IDDOI:10.1200/jco.19.00925Published Date2020-02-10JournalJournal of Clinical Oncology, 2020-02-10, Volume 38
PURPOSE Platinum-based therapy is the standard of care in patients who have HER2-negative, advanced esophagogastric cancer (AEGC). Retrospective data suggest that intratumoral ERCC1 levels may determine platinum sensitivity. A randomized, phase II study was performed in patients with AEGC to explore whether the efficacy of a platinum-based therapy with fluorouracil, leucovorin, and oxaliplatin (FOLFOX) versus a non–platinum-containing regimen of irinotecan and docetaxel (IT) differed accordin…
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