42
42
40
40
54
54
75
75
56
56
83
83
84
84
92
92
106
106
63
63
2020
2008
University (1.7K)Research Institution (94)Hospital (92)Foundation (12)Company (3)
1 - 10 of 1,751
Sort by
Publication
ID32405973Published Date2020-07-01JournalMolecular and cellular biochemistry, 2020-07-01, Volume 470
More than 80% of maturity-onset diabetes of the young (MODY) in Chinese is genetically unexplained. To investigate whether the insulin gene (INS) mutation is responsible for some Chinese MODY, we screened INS mutations causing MODY10 in MODY pedigrees and explored the potential pathogenic mechanisms. INS mutations were screened in 56 MODY familial probands. Structure-function characterization and clinical profiling of identified INS mutations were conducted. An INS mutation, at the position 2…
Publication
ID32426415Published Date2020-06-12JournalMolecular therapy. Methods & clinical development, 2020-06-12, Volume 17
Hematopoietic stem cell gene therapy is a promising approach for treating disorders of the hematopoietic system. Identifying combinations of -regulatory elements that do not impede packaging or transduction efficiency when included in lentiviral vectors has proven challenging. In this study, we deploy LV-MPRA (lentiviral vector-based, massively parallel reporter assay), an approach that simultaneously analyzes thousands of synthetic DNA fragments in parallel to identify sequence-intrinsic and…
Publication
ID32368438Published Date2020-06-01JournalPreventive medicine reports, 2020-06-01, Volume 18
We partnered with African American churches in South Los Angeles (LA) and trained Community Health Advisors (CHAs) to assess cancer screening. The purpose of this analysis is to report adherence to national cancer screening guidelines among African Americans in South LA, to assess relationships between adherence to colorectal cancer and other cancer screening guidelines, and to explore regional differences in screening rates. Between 2016 and 2018, 44 CHAs surveyed 777 African Americans betwe…
Publication
ID32471499Published Date2020-05-29JournalCell communication and signaling : CCS, 2020-05-29, Volume 18
Chemokines are a family of small cytokines, which guide a variety of immune/inflammatory cells to the site of tumor in tumorigenesis. A dysregulated expression of chemokines is implicated in different types of cancer including prostate cancer. The progression and metastasis of prostate cancer involve a complex network of chemokines that regulate the recruitment and trafficking of immune cells. The chemokine CCL2 and its main receptor CCR2 have been receiving particular interest on their roles…
Publication
ID32451329Published Date2020-05-25JournalMolecular cancer therapeutics, 2020-05-25
Little is known about the role of epithelial membrane protein-2 (EMP2) in breast cancer development or progression. In this study, we tested the hypothesis that EMP2 may regulate the formation or self-renewal of breast cancer stem cells (BCSC) in the tumor microenvironment. In silico analysis of gene expression data demonstrated a correlation of EMP2 expression with known metastasis related genes and markers of cancer stem cells (CSC) including aldehyde dehydrogenase (ALDH). In breast cancer …
Publication
ID32455851Published Date2020-05-21JournalCancers, 2020-05-21, Volume 12
PolyADP ribosylation (PARylation) by PARP1 is a significant post-translational modification affecting protein function in various cancers. However, PARP1 mediated cellular processes in the context of breast cancer are not fully understood.To identify potential targets of PARP1, we carried out whole transcriptome sequencing with shRNA mediated PARP1 knockdown in triple-negative breast cancer (TNBC) cell line and inhibited PARP1 with a known PARP1 inhibitor, PJ34.Analysis of the transcriptomics…
Publication
IDDOI:10.1210/jendso/bvaa046.543Published Date2020-05-08JournalJournal of the Endocrine Society, 2020-05-08, Volume 4
Abstract BACKGROUND: The normal thyroid secretes T4 (an inactive precursor), T3 (the active hormone) and reverse T3, a biologically inactive form of T3 that may block T3 from binding to the thyroid hormone receptor. As about 15% of patients on L-T4 replacement with a normalized TSH report continued fatigue and other hypothyroid symptoms, efforts are needed to understand this phenomenon. Decades ago, endocrinologists realized that in severe illnesses, rT3 is often high and T3 is often low and …
Publication
IDDOI:10.1210/jendso/bvaa046.691Published Date2020-05-08JournalJournal of the Endocrine Society, 2020-05-08, Volume 4
Abstract Electronic nicotine delivery systems or electronic cigarettes (e-cigarettes) are becoming exceptionally popular in the world as an alternative to conventional nicotine cigarettes, both in smokers and people who have never smoked. Nicotine can induce lipolysis in adipose tissue, leading to increased serum free fatty acids (FFA). Increased levels of FFA are one of the key elements in inducing a pro-inflammatory response and lead to ectopic lipid accumulation, lipotoxicity, mitochondria…
Publication
IDDOI:10.1210/jendso/bvaa046.1465Published Date2020-05-08JournalJournal of the Endocrine Society, 2020-05-08, Volume 4
Abstract CARF (Collaborator of ARF), a member of ARF-MDM2-p53 pathway and an emerging multifunctional protein, regulates cellular fate in response to various stresses including oxidative DNA damage and replicative stresses. However, its role in metabolic syndrome (MS) and associated diseases has not been studied. This study, using our well established in vivo and in vitro model systems, examines the role of CARF in the development of non-alcoholic fatty liver disease (NAFLD). Indeed, we have …
Publication
IDDOI:10.1210/jendso/bvaa046.1594Published Date2020-05-08JournalJournal of the Endocrine Society, 2020-05-08, Volume 4
Abstract Non-alcoholic fatty liver disease (NAFLD) is a common chronic liver condition. It is manifested by hepatic steatosis (HS) that can progress to non-alcoholic steatohepatitis (NASH), and even liver failure. Interestingly, it is marked by racial/ethnic disparities, with a high prevalence in Hispanics. We aimed to identify the risk factors for these chronic conditions in the US. To this end, we analyzed data from NHANES III (1988-1994) using multiple or multinomial logistic regression co…
We found 1,751 documents that match your Search
Research Grants: 90
Publications: 1,661

Wellspring Search is the world's most comprehensive collection of enriched content about emerging and licensable technology innovations.


Already a member? Sign in