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ID31992618Published Date2020-01-28JournalmBio, 2020-01-28, Volume 11
New antimalarial drugs are needed. The benzoxaborole AN13762 showed excellent activity against cultured , against fresh Ugandan isolates, and in murine malaria models. To gain mechanistic insights, we selected for isolates resistant to AN13762. In all of 11 independent selections with 100 to 200 nM AN13762, the 50% inhibitory concentration (IC) increased from 18-118 nM to 180-890 nM, and whole-genome sequencing of resistant parasites demonstrated mutations in prodrug activation and resistance…
Publication
ID31905778Published Date2019-12-29JournalGenes, 2019-12-29, Volume 11
Cave animals are a fascinating group of species often demonstrating characteristics including reduced eyes and pigmentation, metabolic efficiency, and enhanced sensory systems. , an isopod crustacean, is an emerging model for cave biology. Cave and surface forms of this species differ in many characteristics, including eye size, pigmentation, and antennal length. Existing resources for this species include a linkage map, mapped regions responsible for eye and pigmentation traits, sequenced ad…
Publication
ID31863698Published Date2019-12-03JournalInternational journal of nursing education scholarship, 2019-12-03, Volume 16
Although leadership theory is introduced in baccalaureate nursing curriculum, opportunities to practice and develop leadership skills are limited for undergraduate nursing students. This study explores the experience of advanced nursing students who provided mentoring and tutoring to beginning nursing students. The experiences they describe are interpreted in light of literature on leadership education in undergraduate nursing schools, as well as that of peer mentoring and peer teaching. Thes…
Publication
IDDOI:10.1177/2329490619853242Published Date2019-12-01JournalBusiness and Professional Communication Quarterly, 2019-12-01, Volume 82
In order for students to effectively transfer oral communication skills from academic to professional settings, they must have high oral communication self-efficacy. We significantly increased oral communication self-efficacy in a sample of 97 undergraduate business majors by incorporating enactive mastery, vicarious experience, verbal persuasion, and physiological arousal into a business communication course. Self-efficacy was positively and significantly correlated with course performance, …
Publication
IDDOI:10.1177/0013124519887713Published Date2019-11-13JournalEducation and Urban Society, 2019-11-13
As the push and expectation to attend college continues to increase, making the process of getting into college more competitive than ever before, there is a need to interrogate whether and how efforts to create a college-going culture and increase college readiness among students, particularly those from historically marginalized backgrounds, might have an adverse impact on students. This study illuminates 59 students’ voices who participated in a multisite descriptive case study examining t…
Publication
ID31494077Published Date2019-11-05JournalEuropean journal of pharmacology, 2019-11-05, Volume 862
Flexible heteroarotinoids (Flex-Hets) are compounds with promising anti-cancer activities. SHetA2, a first-generation Flex-Het, has been shown to inhibit the growth of cervical, head and neck, kidney, lung, ovarian, prostate, and breast cancers. However, SHetA2's high lipophilicity, limited selectivity, low oral bioavailability, and complicated synthesis has led to the development of second-generation compounds, such as 1-(1-(naphthalen-1-yl)ethyl)-3-(4-nitrophenyl) thiourea or SL-1-09. Resul…
Publication
IDDOI:10.1177/0145482x19868351Published Date2019-09-01JournalJournal of Visual Impairment & Blindness, 2019-09-01, Volume 113
Introduction: In spite of the vast amount of literature on pet therapy and dog companionship, limited studies exist on older adults with vision loss and the experience of owning a dog guide. The purpose of this study is to explore the facilitators and barriers of first-time ownership and utilization of a dog guide as experienced by older adults with vision loss. Methods: Data were gathered among seven participants using open-ended semistructured telephone interviews. Participants described th…
Publication
ID31431634Published Date2019-08-20JournalScientific reports, 2019-08-20, Volume 9
Cadmium is an environmental contaminant that can activate estrogen receptor alpha (ERα) and contribute to the development and progression of breast cancer. Our lab previously demonstrated that chronic cadmium exposure alters the expression of several ERα-responsive genes and increases the malignancy of breast cancer cells. Although these studies support cadmium's function as a hormone disrupter, the role of ERα in cadmium-induced breast cancer progression remains unclear. To address this, we …
Publication
ID31990836Published Date2020-02-01JournalJAAPA : official journal of the American Academy of Physician Assistants, 2020-02-01, Volume 33
Publication
IDDOI:10.1177/2329488419863097Published Date2019-07-13JournalInternational Journal of Business Communication, 2019-07-13
We asked 30 top executives (CEOs, COOs, and Presidents) to describe their paths to and in office. Our purpose was to explore how executives practice leadership in the way they discuss their experience. We identified three structures that interviewees used: the full proof, a thesis statement backed by evidence; the narrative plot, a trajectory toward a goal; and the signature story, a defining leadership experience. We argue that structuration proves leadership; that is, full proofs and narrat…
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