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Patent
Publication NumberEP 2114420 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2008-02-15Publication Date2016-01-27
Patent
Publication NumberEP 2016182 B8Filing StatusIssued PatentAvailabilityUnknownFiling Date2007-05-04Publication Date2015-09-02
Patent
Publication NumberUS 9085777Filing StatusIssued PatentAvailabilityUnknownFiling Date2007-05-04Publication Date2015-07-21
The present invention includes a method of generating a mutant Herpes Simplex Virus (HSV). In one embodiment, the generated HSV genome includes nucleic acid encoding a nucleic acid sequence of interest. In one step, a nucleic acid vector is provided which includes a nucleic acid encoding first and second site specific recombination sequences and a nucleic acid encoding a nucleic acid sequence of interest between said site specific recombination sequences an HSV is provided, the genome of whic…
Patent
Publication NumberUS 8980282Filing StatusIssued PatentAvailabilityUnknownFiling Date2008-04-02Publication Date2015-03-17
Herpes Simplex Viruses are disclosed having single-chain antibodies (scFv) embedded in the viral envelope via fusion with glycoprotein D and with glycoprotein H and L.
Patent
Publication NumberUS 8969063Filing StatusIssued PatentAvailabilityUnknownFiling Date2012-03-12Publication Date2015-03-03
A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.
Patent
Publication NumberUS 8778684Filing StatusIssued PatentAvailabilityUnknownFiling Date2011-04-13Publication Date2014-07-15
There is provided an HSV complex which comprises an avirulent HSV and a targeting agent which allows the HSV particle to infect and lyse a specific targeted cell. The inventors have found a way in which avirulent HSV can be targeted to disease cells, e.g. cancer cells, by incorporating an antibody binding domain into one or more viral glycoproteins.
Patent
Publication NumberEP 1474521 B2Filing StatusIssued PatentAvailabilityUnknownFiling Date2003-02-12Publication Date2014-02-26
Patent
Publication NumberUS 8530437Filing StatusIssued PatentAvailabilityUnknownFiling Date2009-05-06Publication Date2013-09-10
An herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding an antisense to the squamous cell carcinoma related oncogene (asSCCRO); and an herpes simplex virus wherein the herpes simplex virus genome comprises nucleic acid encoding a short interfering ribonucleic acid (siRNA) molecule that is capable of repressing or silencing expression of squamous cell carcinoma related oncogene (SCCRO) nucleic acid or polypeptide are disclosed together with methods for g…
Patent
Publication NumberUS 20120141418Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2011-11-28Publication Date2012-06-07
Use as an anti-cancer agent of a mutant herpes simplex virus wherein the mutant virus comprises a modification in the γ34.5 gene in the long repeat region (RL) such that the γ34.5 gene is a non-functional, manufacture of medicaments and methods of testing cancer in mammals employing HSV mutant.
Patent
Publication NumberUS 8163292Filing StatusIssued PatentAvailabilityUnknownFiling Date2008-02-15Publication Date2012-04-24
A herpes simplex virus is disclosed in which the herpes simplex virus genome comprises a nucleic acid sequence encoding an ING4 polypeptide.
We found 33 documents that match your Search
Patents: 33

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