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Publication
ID30638635Published Date2019-06-01JournalEuropean urology, 2019-06-01, Volume 75
Increasing evidence suggests that lifestyle factors may decrease the risk of prostate cancer progression. Lifestyle guidelines and tools may support lifestyle modification after diagnosis.To determine the feasibility and acceptability of a digital lifestyle intervention among men with prostate cancer.A 12-wk pilot randomized controlled trial among 76 men with clinical stage T1-T3a prostate cancer. Eligibility included Internet access, no contraindications to aerobic exercise, and engaging in …
Publication
ID30742903Published Date2019-06-01JournalExperimental gerontology, 2019-06-01, Volume 120
Lysosome function is compromised during aging and in many disease states. Interventions that promote lysosomal activity and acidification are thus of prime interest as treatments for longevity and health. Intracellular pH can be controlled by the exchange of protons for inorganic ions, and in cells from microbes to man, when potassium is restricted in the growth medium, the cytoplasm becomes acidified. Here we use a yeast model to show that potassium limited-cells exhibit hallmarks of increas…
Publication
ID30968123Published Date2019-06-01JournalThe Journal of nutrition, 2019-06-01, Volume 149
Moderate acute malnutrition (MAM) affects 34.1 million children globally. Treatment effectiveness is generally determined by the amount and rate of weight gain. Body composition (BC) assessment provides more detailed information on nutritional stores and the type of tissue accrual than traditional weight measurements alone.The aim of this study was to compare the change in percentage fat mass (%FM) and other BC parameters among young Malian children with MAM according to receipt of 1 of 4 die…
Patent
Publication NumberUS 10300034StatusIssued PatentAvailabilityUnknownFiling Date2008-02-19Publication Date2019-05-28
The present invention provides dietary formulations comprising polyunsaturated fatty acids and vitamin E. The present invention further provides methods of treating various conditions, generally involving administering to an individual in need thereof an effective amount of a subject dietary formulation.
Publication
ID31092690Published Date2019-05-14JournalJournal of lipid research, 2019-05-14
Hypertriglyceridemia results from accumulation of triglyceride (TG)-rich lipoproteins (TRLs) in the circulation and is associated with increased cardiovascular disease risk. ApoC-III is an apolipoprotein on TRLs and a prominent negative regulator of TG catabolism. We recently established that in vivo apoC-III predominantly inhibits LDLR and LRP1 mediated hepatic TRL clearance and that apoC-III enriched TRLs are preferentially cleared by syndecan-1 (SDC1). In this study, we determined the impa…
Patent
Publication NumberUS 20190136295StatusPatent ApplicationAvailabilityUnknownFiling Date2017-05-04Publication Date2019-05-09
Disclosed herein are novel methods and compositions for rapidly extracting and amplifying nucleic acids from a sample where the sample is combined with an extraction reagent comprising a reducing agent to form a mixture and incubating said mixture at ambient temperature for a period of time not exceeding 30 minutes to generate a nucleic acid extract. In certain embodiments of the method, the nucleic acid extract is subjected to a nucleic acid amplification reaction. In certain aspects, oligon…
Publication
ID30980696Published Date2019-05-01JournalCytometry. Part A : the journal of the International Society for Analytical Cytology, 2019-05-01, Volume 95
Red blood cells (RBCs) from sickle cell patients exposed to a low oxygen tension reveal highly heterogeneous cell morphologies due to the polymerization of sickle hemoglobin (HbS). We show that angle-resolved light scattering approach with the use of image-based flow cytometry provides reliable quantitative data to define the change in morphology of large populations of RBCs from sickle cell patients when the cells are exposed for different times to low oxygen. We characterize the RBC morphol…
Publication
ID31057213Published Date2019-05-01JournalJournal of food composition and analysis : an official publication of the United Nations University, International Network of Food Data Systems, 2019-05-01, Volume 78
Phytate is widely distributed in the plant kingdom, and its significance for human nutrition has been often described. Data on phytate is available in very few composition tables, for a limited number of foods and mainly for raw products. With the aim of publishing the first global repository of analytical data on phytate, data on moisture, phytate, zinc, iron and calcium were compiled. Other aspects, such as the analytical method used, biodiversity and processing, were considered, and phytat…
Clinical Trial
Clinical Trial IDNCT03934346Start Date2019-05-01Completion Date2019-08-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
Zinc may be absorbed from diet via zinc transporter mediated pathways, or, when coupled with amino acids, via amino acid transporter pathways. When zinc is coupled with amino acids in diet, it may dissociate from those amino acids in the acidic environment of the stomach prior to entering the small intestine. An experimentally-determined value for any pre-absorptive dissociation of zinc from a zinc amino acid complex (ZnAA) is necessary for the accurate compartmental modeling of zinc metaboli…
Publication
ID30854694Published Date2019-05-01JournalAlimentary pharmacology & therapeutics, 2019-05-01, Volume 49
Dyslipidaemia is frequent in non-alcoholic steatohepatitis (NASH); however, it is unclear if improvement in liver histology is associated with favourable changes in cardiovascular disease (CVD) risk.To evaluate the relationship of NASH resolution and lipoprotein subfraction levels, markers of endothelial dysfunction, and macrophage activation.One hundred and seventeen individuals with NASH who participated in the Pioglitazone vs Vitamin E vs Placebo for the Treatment of Nondiabetic Patients w…
We found 2,848 documents that match your Search
Research Grants: 884
Publications: 1,130
Patents: 179
Clinical Trials: 255
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