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Publication
ID31484776Published Date2019-09-04JournalProceedings of the National Academy of Sciences of the United States of America, 2019-09-04
Rapid advances in genomic technologies have led to a wealth of diverse data, from which novel discoveries can be gleaned through the application of robust statistical and computational methods. Here, we describe GeneFishing, a semisupervised computational approach to reconstruct context-specific portraits of biological processes by leveraging gene-gene coexpression information. GeneFishing incorporates multiple high-dimensional statistical ideas, including dimensionality reduction, clustering…
Patent
Publication NumberUS 10398671StatusIssued PatentAvailabilityUnknownFiling Date2017-02-03Publication Date2019-09-03
The present invention provides dietary formulations comprising polyunsaturated fatty acids and vitamin E. The present invention further provides methods of treating various conditions, generally involving administering to an individual in need thereof an effective amount of a subject dietary formulation.
Publication
ID31214942Published Date2019-09-01JournalCurrent obesity reports, 2019-09-01, Volume 8
This paper reviews the genetic and non-genetic factors that provided predictions of, or were associated with, weight loss and other metabolic changes in the POUNDS Lost clinical trial of weight loss. This trial randomized 811 individuals who were overweight or obese to one of four diets that contained either 15% or 25% protein and 20% or 40% fat in a 2 × 2 factorial design. A standard behavioral weight loss program was available for all participants who were followed for 2 years with an 80% c…
Web Document
Date Added2019-09-03
Children's Hospital Oakland Research Institute 5700 Martin Luther King Jr. Way Oakland, California 94609-1673 Institutional Information Legal Entity Name and Address Children's Hospital & Research Center at Oakland 747 52nd Street Oakland, California 94609-1809 Taxation Information Children's Hospital & Research Center at Oakland is a 501(c)(3) not-for-profit research and healthcare organization (Other than Institution of Higher Education) Federal Tax ID number (TIN/EIN): 94-0382330 Federal T…
Web Document
Date Added2019-09-02
C H O R I | Sponsored Programs Office (SPO)   ABOUT CHORI A Brief History Facility Directions CHORI Leadership Sponsored Programs and CGA Technology Transfer Global Health Initiative Children's Hospital Oakland Careers at CHORI   SPONSORED PROGRAMS and CGA OFFICE Overview Program Staff Forms, Guidance & Quick Links       Sponsored programS and Contracts & Grant ACCounting (CGA) Proposal Forms: 1. Proposal Routing Form 2. PI Assurance of Compliance Statement 3. Statement of Intent to Enter int…
Publication
ID31434105Published Date2019-08-21JournalPediatric research, 2019-08-21
Mucopolysaccharidosis I (MPS IH) is a lysosomal storage disease treated with hematopoietic cell transplantation (HCT) because it stabilizes cognitive deterioration, but is insufficient to alleviate all somatic manifestations. Intravenous laronidase improves somatic burden in attenuated MPS I. It is unknown whether laronidase can improve somatic disease following HCT in MPS IH. The objective of this study was to evaluate the effects of laronidase on somatic outcomes of patients with MPS IH pre…
Web Document
Date Added2019-09-02
C H O R I | Sponsored Programs Office (SPO)   ABOUT CHORI A Brief History Facility Directions CHORI Leadership Sponsored Programs and CGA Technology Transfer Global Health Initiative Children's Hospital Oakland Careers at CHORI   SPONSORED PROGRAMS and CGA OFFICE Overview Program Staff Forms, Guidance & Quick Links           Sponsored programS and Contracts & Grant ACCounting (CGA) CHORI 5700 Martin Luther King Jr. Way Oakland, CA 94609 Phone: (510) 450-7606 Fax: (510) 450-7973 Program Staff …
Publication
ID31408370Published Date2019-08-13JournalEuropean journal of preventive cardiology, 2019-08-13
Despite major efforts to reduce atherosclerotic cardiovascular disease (ASCVD) burden with conventional risk factor control, significant residual risk remains. Recent evidence on non-traditional determinants of cardiometabolic health has advanced our understanding of lifestyle-disease interactions. Chronic exposure to environmental stressors like poor diet quality, sedentarism, ambient air pollution and noise, sleep deprivation and psychosocial stress affect numerous traditional and non-tradi…
Web Document
Date Added2019-09-03
Date: Aug 1, 2019 8:15 AM Subject: RE: CHORI F&A Rate Proposal FY 2017-18 Your proposal has been received and is in our workload awaiting review. Due to retirements, we have a heavy workload and will try to get to your assignment as soon as possible. In the meantime, if you have any inquiries from Federal awards officials regarding the indirect rates, please let them know they can contact us and we will answer their questions. Your current rates should be acceptable until the in-house proposa…
Publication
ID31415568Published Date2019-08-01JournalPLoS genetics, 2019-08-01, Volume 15
Elevated uric acid (UA) is a key risk factor for many disorders, including metabolic syndrome, gout and kidney stones. Despite frequent occurrence of these disorders, the genetic pathways influencing UA metabolism and the association with disease remain poorly understood. In humans, elevated UA levels resulted from the loss of the of the urate oxidase (Uro) gene around 15 million years ago. Therefore, we established a Drosophila melanogaster model with reduced expression of the orthologous Ur…
We found 2,873 documents that match your Search
Research Grants: 884
Publications: 1,147
Patents: 180
Clinical Trials: 254
Web Documents: 408

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