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Publication
ID31756249Published Date2020-01-01JournalAmerican journal of health-system pharmacy : AJHP : official journal of the American Society of Health-System Pharmacists, 2020-01-01, Volume 77
To examine the reporting rates of adverse drug events (ADEs) with apixaban and empagliflozin as reports move up to the next level of spontaneous reporting.This was a retrospective cohort study of outpatients who discontinued apixaban or empagliflozin within 3 years of Food and Drug Administration (FDA) approval. We enriched the sample using an active surveillance strategy to identify subsets of patients with International Classification of Diseases (ICD) codes possibly associated with an ADE.…
Publication
ID31858867Published Date2019-12-20JournalPharmaceutical development and technology, 2019-12-20
Tocosol™ is a tocopherol-based paclitaxel (PTX) mini-emulsion consisting of α-tocopherol (α-T) isomer of vitamin E as a solubilizer and vitamin E TPGS as the primary emulsifier. Despite its positive attributes in early clinical studies, it failed the pivotal phase III clinical trial. The long-term goal of this work was to reformulate Tocosol™. In this study, Tocosol™ formulation was optimized by replacing the α-T isomer with the more pharmacological active isomer γ-tocotrienol (γ-T), and the …
Publication
ID31563612Published Date2019-12-01JournalMolecular phylogenetics and evolution, 2019-12-01, Volume 141
Using numerical methods for genome comparison has always been of importance in bioinformatics. The Chaos Game Representation (CGR) is an effective genome sequence mapping technology, which converts genome sequences to CGR images. To each CGR image, we associate a vector called an Extended Natural Vector (ENV). The ENV is based on the distribution of intensity values. This mapping produces a one-to-one correspondence between CGR images and their ENVs. We define the distance between two DNA seq…
Publication
ID31595522Published Date2019-12-01JournalThe Journal of pharmacy and pharmacology, 2019-12-01, Volume 71
The study aimed to identify nutmeg compounds that indirectly interact with the endocannabinoid system through inhibition of the fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MAGL) enzymes.Thirteen compounds were screened for FAAH and MAGL inhibition. Compounds demonstrating significant FAAH inhibition were evaluated to determine the halfmaximal inhibitory concentration (IC ). The most potent compound was investigated in the elevated plus maze (EPM) rodent anxiety model.Three …
Publication
ID30529533Published Date2019-12-01JournalGenomics, 2019-12-01, Volume 111
This study quantitatively validates the principle that the biological properties associated with a given genotype are determined by the distribution of amino acids. In order to visualize this central law of molecular biology, each protein was represented by a point in 250-dimensional space based on its amino acid distribution. Proteins from the same family are found to cluster together, leading to the principle that the convex hull surrounding protein points from the same family do not inters…
Publication
ID31765217Published Date2019-11-08JournalPhysical review letters, 2019-11-08, Volume 123
The first measurement of the ϒ(1S) elliptic flow coefficient (v_{2}) is performed at forward rapidity (2.5
Publication
ID31683009Published Date2019-11-01JournalInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2019-11-01, Volume 77
HIV-1 is the most common and pathogenic strain of human immunodeficiency virus consisting of many subtypes. To study the difference among HIV-1 subtypes in infection, diagnosis and drug design, it is important to identify HIV-1 subtypes from clinical HIV-1 samples. In this work, we propose an effective numeric representation called Subsequence Natural Vector (SNV) to encode HIV-1 sequences. Using the representation, we introduce an improved linear discriminant analysis method to classify HIV-…
Publication
IDDOI:10.1093/ofid/ofz360.1004Published Date2019-10-23JournalOpen Forum Infectious Diseases, 2019-10-23, Volume 6
Abstract Background Clinical practice surrounding neonatal sepsis varies significantly among physicians. In efforts to confront the challenge of inappropriate and overuse of antimicrobials in our Neonatal Intensive Care Unit (NICU), a multidisciplinary team developed a guideline for the evaluation and management of suspected and proven sepsis within the NICU in preterm infants. We evaluated the antimicrobial utilization before and after the implementation of our guideline, developed in July 2…
Publication
ID31702212Published Date2019-10-04JournalPhysical review letters, 2019-10-04, Volume 123
Measurements of anisotropic flow coefficients (v_{n}) and their cross-correlations using two- and multiparticle cumulant methods are reported in collisions of pp at sqrt[s]=13 TeV, p-Pb at a center-of-mass energy per nucleon pair sqrt[s_{NN}]=5.02 TeV, Xe-Xe at sqrt[s_{NN}]=5.44 TeV, and Pb-Pb at sqrt[s_{NN}]=5.02 TeV recorded with the ALICE detector. The multiplicity dependence of v_{n} is studied in a very wide range from 20 to 3000 particles produced in the midrapidity region |η|
Research Grant
IDW911NF1910519Funding AgencyDepartment of DefenseEffective Date2019-09-20Expiration Date2020-09-19Funding Amount$470,796
From creating polymer ammunition magazines to reduce weapon failure rates to embedding nanotubes into fabric to provide uniforms that can respond to environmental changes, polymers play a critical role for the military. In fact, polymers are crucial to modern American society with over 300 tonnes manufactured yearly, both as new materials and as a growing environmental concern. Since the DoDÕs STEM initiative, created to develop a Òtalent pool with minds for innovation, diversity of thought,…
We found 730 documents that match your Search
Research Grants: 274
Publications: 455
Patents: 1

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