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Patent
Publication NumberLT 3421601 TFiling StatusOtherAvailabilityUnknownFiling Date2012-12-31Publication Date2020-01-10
The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provides …
Patent
Publication NumberUS 20190321490Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-12-19Publication Date2019-10-24
The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provides …
Patent
Publication NumberWO 2019161400 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-02-19Publication Date2019-08-22
Provided are compositions and methods for treating a subject having a primary immune deficiency (PID), for example who is suffering from a chronic viral, bacterial, or fungal infection, using autologous granulocytes, autologous lymphocytes, and/or NK cells containing exogenous mRNA encoding the missing or defective protein.
Patent
Publication NumberUS 10201620Filing StatusIssued PatentAvailabilityUnknownFiling Date2012-12-31Publication Date2019-02-12
The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provides …
Patent
Publication NumberAU 2018264152 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-11-16Publication Date2018-12-06
The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is 5 repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provide…
Patent
Publication NumberUS 20180312806Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-11-28Publication Date2018-11-01
The present invention provides methods, kits, and compositions for reducing an innate immune system response in a human or animal cell, tissue or organism. One embodiment comprises: introducing an Agent mRNA comprising in vitro-synthesized mRNA encoding one or more proteins that affect the induction, activity or response of an innate immune response pathway; whereby, the innate immune response in the cell, tissue or organism is reduced compared to the innate immune response in the absence of …
Patent
Publication NumberPL 3144389 T3Filing StatusOtherAvailabilityUnknownFiling Date2012-12-31Publication Date2018-10-31
The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provides …
Patent
Publication NumberUS 20180265848Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-05-31Publication Date2018-09-20
The present invention provides compositions and methods for reprogramming somatic cells using purified RNA preparations comprising single-strand mRNA encoding an iPS cell induction factor. The purified RNA preparations are preferably substantially free of RNA contaminant molecules that: i) would activate an immune response in the somatic cells, ii) would decrease expression of the single-stranded mRNA in the somatic cells, and/or iii) active RNA sensors in the somatic cells. In certain embodi…
Patent
Publication NumberAU 2017251767 B2Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-10-25Publication Date2018-08-16
The present invention relates to compositions, kits and methods for making and using RNA compositions comprising in vitro-synthesized ssRNA inducing a biological or biochemical effect in a mammalian cell or organism into which the RNA composition is 5 repeatedly or continuously introduced. In certain embodiments, the invention provides compositions and methods for changing the state of differentiation or phenotype of a human or other vertebrate cell. For example, the present invention provide…
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