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Research Grant
Project Number1R43CA247832-01Funding AgencyNational Institutes of HealthEffective Date2019-09-18Expiration Date2020-09-17Funding Amount$147,147
Project Summary Annually, over 1.2 million CT-guided lung biopsies are performed worldwide for lung cancer diagnosis (~400,000 in the US). Pneumothorax (PTX) ? a collapsed lung, is the most common complication of this procedure, occurring in 20-40% of all CT-guided lung biopsies. In 10-15% of lung biopsies, the patient becomes symptomatic due to PTX and requires an invasive chest tube insertion, the definitive treatment for PTX. This complication costs, on an average, $15k per chest tube inse…
Patent
Publication NumberUS 20180194042Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-03-07Publication Date2018-07-12
The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
Patent
Publication NumberUS 9968709Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-06-24Publication Date2018-05-15
The present invention relates to methods for making cross-linked oxidation-resistant polymeric materials and preventing or minimizing in vivo elution of antioxidant from the antioxidant-containing polymeric materials. The invention also provides methods of doping polymeric materials with a spatial control of cross-linking and antioxidant distribution, for example, vitamin E (α-Tocopherol), and methods for extraction/elution of antioxidants, for example, vitamin E (α-tocopherol), from surface …
Patent
Publication NumberUS 9962463Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-06-16Publication Date2018-05-08
The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
Patent
Publication NumberUS 9943993Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-05-16Publication Date2018-04-17
The present invention relates to methods for making oxidation resistant medical devices that comprise polymeric materials, for example, ultra-high molecular weight polyethylene (UHMWPE). The invention also provides methods of making antioxidant-doped medical implants, for example, doping of medical devices containing cross-linked UHMWPE with vitamin E by diffusion and materials used therein.
Patent
Publication NumberCA 2679274 CFiling StatusIssued PatentAvailabilityUnknownFiling Date2008-03-03Publication Date2018-02-20
The present invention relates to methods for making cross-linked, oxidatively stable, and highly crystalline polymeric materials. The invention also provides methods of treating irradiation-cross-linked antioxidant-containing polymers and materials used therewith.
Patent
Publication NumberUS 9873769Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-07-10Publication Date2018-01-23
A method of forming thiolated poly(vinyl alcohol) hydrogels including reacting, in the presence of an acid, compounds containing a thiol functional group and a hydroxyl reactive group with one or more hydroxyl groups of poly(vinyl alcohol) via said hydroxyl reactive group, thereby forming thiolated poly(vinyl alcohol). The method further including reacting the thiol functional group of said compounds with a thiol reactive group of a crosslinker, thereby forming a hydrogel.
Patent
Publication NumberEP 1750614 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2005-05-10Publication Date2017-09-27
Research Grant
Project Number1R43EY027635-01Funding AgencyNational Institutes of HealthEffective Date2017-09-01Expiration Date2018-08-31Funding Amount$224,397
Project Summary Retinal disorders are a common cause of debilitating vision loss. For many of these conditions, including retinal detachments and macular holes, the only treatment is surgery. The first step of all such surgeries is vitrectomy, the process of removing the vitreous gel through tiny ports in the front of the eye. Each year, 1.1 million vitrectomies are performed globally with 300,000 performed in the US alone, and in the majority of these cases a retinal tamponade is required to…
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Research Grants: 11
Patents: 109

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