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Research Grant
Project Number5SC3GM132056-02Funding AgencyNational Institutes of HealthEffective Date2020-04-01Expiration Date2021-03-31Funding Amount$103,200
PROJECT SUMMARY/ABSTRACT Many important cellular events are regulated by antagonistic mechanisms, and understanding how factors involved in the regulation of tumorigenesis execute their antagonistic functions is particularly important. Histone H2A mono-ubiquitination at K119 mediated by polycomb repressive complex 1 (PRC1) is an important epigenetic mark associated with epithelial-mesenchymal transition (EMT) and cell invasion during early metastasis. However, less is known about the function…
Research Grant
Project Number1SC3GM135046-01Funding AgencyNational Institutes of HealthEffective Date2020-02-10Expiration Date2021-01-31Funding Amount$110,250
PROJECT SUMMARY Trichomonas vaginalis is a unicellular, motile protozoan parasite responsible for the 3rd- most common sexually-transmitted infection in the US and worldwide. While around half of T. vaginalis infections are asymptomatic, symptoms of the infection can range from vaginitis and frothy discharge, to male and female infertility, pre-terms births, increased incidences of malignant cervical cancers, and increased spread of HIV. T. vaginalis was recently classified as a neglected inf…
Research Grant
Project Number5SC3GM125570-03Funding AgencyNational Institutes of HealthEffective Date2020-02-01Expiration Date2021-01-31Funding Amount$99,225
Project Summary This project follows up on our recent research implicating the neurotransmitter dopamine signaling as key mediator of circadian timing systems. Our main hypothesis is a subpopulation of dopaminergic neurons send signals to a population of dopamine type 1 receptor 1 (D1r)-expressing neurons in the dorsal striatum, constituting a critical link between food intake and circadian rhythms of daily activity. To address this hypothesis we propose to generate several genetically modifi…
Publication
ID31902720Published Date2020-01-20JournalCurrent biology : CB, 2020-01-20, Volume 30
The widespread availability of energy-dense, rewarding foods is correlated with the increased incidence of obesity across the globe. Overeating during mealtimes and unscheduled snacking disrupts timed metabolic processes, which further contribute to weight gain. The neuronal mechanism by which the consumption of energy-dense food restructures the timing of feeding is poorly understood. Here, we demonstrate that dopaminergic signaling within the suprachiasmatic nucleus (SCN), the central circa…
Research Grant
Project Number5SC3GM130472-02Funding AgencyNational Institutes of HealthEffective Date2020-01-01Expiration Date2020-12-31Funding Amount$99,225
PROJECT SUMMARY West Nile virus (WNV) is a significant cause of neuronal injury and inflammation that results in severe disease that can potentially be lethal. In order to reduce or eliminate invading viruses from the central nervous system (CNS) and protect the brain, it is vital that T cells enter the virally-infected CNS and perform their anti-viral functions. However, due to the sensitivity of neurons, the presence activated T cells within the CNS may also contribute to neuropathology if …
Publication
IDDOI:10.1177/0950422219875886Published Date2019-12-01JournalIndustry and Higher Education, 2019-12-01, Volume 33
The authors analyze the recent undertaking in El Salvador to establish an innovative model of industry–higher education clusters that would facilitate collaboration between academia and the private sector – sectors that traditionally had not worked together because of historical distrust – to develop the skilled workforce needed for the country’s future economic growth. Under the USAID Higher Education for Economic Growth project implemented by RTI International, clusters were put forth as th…
Publication
IDDOI:10.1142/s1793351x1940018xPublished Date2019-12-01JournalInternational Journal of Semantic Computing, 2019-12-01, Volume 13
Ontology visualization plays an important role in human data interaction by offering clarity and insight for complex structured datasets. Recent usability studies of ontology visualization techniques have added to our understanding of desired features when assisting users in the interactive process. However, user behavioral data such as eye gaze and event logs have largely been used as indirect evidence to explain why a user may have carried out certain tasks in a controlled environment, as o…
Publication
IDDOI:10.1115/imece2019-10540Published Date2019-11-11JournalVolume 5: Engineering Education, 2019-11-11
Abstract Physical laboratory experiments are built to provide students with hands-on opportunities and have long been crucial for engineering training. However, due to the rapid growth in number of enrollments, limited and shared space, undergraduate students have experienced an increasing difficulty gaining valuable hands on experience in the lab. While traditional lab should never be abandoned, adding virtual labs to assist with it could benefit students without the limitation of enrollment…
Publication
ID31671254Published Date2019-10-31JournalJournal of research on adolescence : the official journal of the Society for Research on Adolescence, 2019-10-31
This study assesses the relationship of parental anger on children's anger and self-derogation from adolescence to young adulthood. We examine a life-course perspective and incorporate theories of emotion regulation and self-referent behavior. Using structural equation models and hierarchical growth curve models with the Kaplan Longitudinal and Multigenerational data, the results indicate that parental anger leads to anger in adolescence, supporting theories of learning through modeling in ad…
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Research Grants: 267
Publications: 119

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