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ID31691369Published Date2019-12-01JournalBirth (Berkeley, Calif.), 2019-12-01, Volume 46
Hospital policies restricting access to trial of labor after cesarean (TOLAC) are prevalent. Many women with a previous cesarean birth are affected by these bans, but there are limited data on the effect of these bans and whether women would consider changing delivery hospitals in the setting of a real or hypothetical TOLAC ban.This was a survey of TOLAC-eligible women receiving prenatal care at four hospitals where TOLAC is available, and 1 non-TOLAC site. Participants were asked about their…
Publication
ID31550979Published Date2019-12-01JournalThe Journal of hand surgery, European volume, 2019-12-01, Volume 44
In the diagnostic work-up of Madelung deformity conventional radiographic imaging is often used, assessing the three-dimensional deformity in a two-dimensional manner. A three-dimensional approach could expand our understanding of Madelung deformity's complex wrist anatomy, while removing inter- and intra-rater differences. We measured previous two-dimensional-based and newly developed three-dimensional-based parameters in 18 patients with Madelung deformity (28 wrists) and 35 healthy partici…
Publication
ID31365298Published Date2019-12-01JournalAmerican journal of respiratory and critical care medicine, 2019-12-01, Volume 200
Less invasive, nonsurgical approaches are needed to treat severe emphysema. To evaluate the effectiveness and safety of the Spiration Valve System (SVS) versus optimal medical management. In this multicenter, open-label, randomized, controlled trial, subjects aged 40 years or older with severe, heterogeneous emphysema were randomized 2:1 to SVS with medical management (treatment) or medical management alone (control). The primary efficacy outcome was the difference in mean FEV from baseline t…
Publication
ID31777144Published Date2019-11-27JournalNeurogastroenterology and motility : the official journal of the European Gastrointestinal Motility Society, 2019-11-27
Epiphrenic (pulsion) esophageal diverticula can occur in the setting of underlying esophageal motility disorders such as achalasia and present a unique management challenge to the gastroenterologist. Asymptomatic diverticula do not require treatment, but symptomatic diverticula require therapy targeted to the underlying esophageal motility disorder, or else the diverticula will recur. Generally, laparoscopic or combined laparoscopic/thoracoscopic myotomy, diverticulectomy, and anterior fundop…
Publication
ID31755954Published Date2019-11-22JournalSleep, 2019-11-22
Determine the association of poor multidimensional sleep health with health-care costs and utilization.We linked 1,459 community-dwelling women (mean age 83.6 years) participating in the Study of Osteoporotic Fractures Year 16 visit (2002-2004) with their Medicare claims. Five dimensions of sleep health (satisfaction, daytime sleepiness, timing, latency, and duration) were assessed by self-report. The number of impaired dimensions was expressed as a score (range 0-5). Total direct health-care…
Publication
ID31739958Published Date2020-01-01JournalGastrointestinal endoscopy clinics of North America, 2020-01-01, Volume 30
Obesity is a public health pandemic and leading contributor to morbidity and mortality. Endoscopic bariatric therapies have emerged as a viable minimally invasive treatment option to fill the therapeutic gap between conservative and surgical approaches. The ability to reliably place full-thickness sutures throughout the gastrointestinal tract has opened the door to novel endoscopic gastric restrictive procedures. A growing body of literature supports endoscopic sleeve gastroplasty as a safe, …
Publication
ID30778527Published Date2019-11-13JournalThe journals of gerontology. Series A, Biological sciences and medical sciences, 2019-11-13, Volume 74
Sleep characteristics related to duration, timing, continuity, and sleepiness are associated with mortality in older adults, but rarely considered in health recommendations. We applied machine learning to: (i) establish the predictive ability of a multidimensional self-reported sleep domain for all-cause and cardiovascular mortality in older adults relative to other established risk factors and (ii) to identify which sleep characteristics are most predictive.The analytic sample includes N = 8…
Publication
ID31722007Published Date2019-11-13JournalThe journals of gerontology. Series A, Biological sciences and medical sciences, 2019-11-13
Extensive work in basic and clinical science suggests that biological mechanisms of aging are causally related to the development of disease and disability in late life. Modulation of the biological mechanisms of aging can extend both life span and health span in animal models, but translation to humans has been slow.Summary of workshop proceedings from the 2018-2019 Epidemiology of Aging Workshop hosted by the Intramural Research Program at the National Institute on Aging.Epidemiologic studi…
Publication
ID31719706Published Date2019-11-12JournalNature reviews. Endocrinology, 2019-11-12
Endocrine-disrupting chemicals (EDCs) are exogenous chemicals that interfere with hormone action, thereby increasing the risk of adverse health outcomes, including cancer, reproductive impairment, cognitive deficits and obesity. A complex literature of mechanistic studies provides evidence on the hazards of EDC exposure, yet there is no widely accepted systematic method to integrate these data to help identify EDC hazards. Inspired by work to improve hazard identification of carcinogens using…
Publication
IDDOI:10.1093/neuonc/noz175.379Published Date2019-11-11JournalNeuro-Oncology, 2019-11-11, Volume 21
Abstract Diffuse intrinsic pontine gliomas (DIPGs) are lethal brain tumors with no effective therapies other than radiation. Inhibitor of DNA binding (ID) proteins are key regulators of tissue and lineage-specific gene differentiation during embryogenesis. Previous work has shown that H3F3A and ACVR1 mutations increase ID1 expression in cultured astrocytes, but this has not been validated in human DIPG, nor has the regulation and targetability of ID1 been explored in DIPG. Analysis of multi-f…
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Publications: 2,728
Patents: 75
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