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ID31985523Published Date2020-07-01JournalCardiology in review, 2020-07-01, Volume 28
Atrial fibrillation is the most common sustained cardiac arrhythmia in the general population. In western countries with aging populations, atrial fibrillation poses a significant health concern, as it is associated with a high risk of thromboembolism, stroke, congestive heart failure, and myocardial infarction. Thrombi are generated in the left atrial appendage, and subsequent embolism into the cerebral circulation is a major cause of ischemic stroke. Therefore, patients have a lifetime risk…
Publication
ID32539075Published Date2020-06-15JournalJAMA neurology, 2020-06-15
Disruption in circadian activity rhythms is very common in older adults, particularly among those with neurodegenerative diseases, including Parkinson disease (PD). However, whether circadian disruption could be a prodrome for PD is unclear.To determine the association between rest-activity rhythm (RAR) and risk of incident PD and to explore whether this association is independent of nighttime sleep disturbances.The ancillary sleep study of the longitudinal cohort Osteoporotic Fractures in Me…
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ID32521549Published Date2020-06-10JournalEndoscopy, 2020-06-10
Colonic anastomotic leaks are associated with significant morbidity and mortality. Whereas small case series suggest that fully covered self-expandable metal stents (FCSEMS) are effective, no larger studies have examined the impact of combination endoscopic therapy on colonic anastomotic leaks. Our retrospective cohort study reviewed 51 patients undergoing endoscopic therapy for colonic anastomotic leaks between 2011 and 2018. Patients receiving combination therapy involving FCSEMS plus local…
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ID32524460Published Date2020-06-10JournalAnnals of surgical oncology, 2020-06-10
Sentinel lymph node biopsy (SLNB) is recommended for intermediate thickness melanoma, but for thick melanoma, guidelines are less definitive about the use of SLNB in this population. We present a study on thick melanoma evaluating for prognostic factors.The Sentinel Lymph Node Working Group database was queried for thick (> 4 mm) melanoma cases that had a SLNB from 1993 to 2018. Clinicopathologic characteristics were correlated with SLN status and melanoma-specific survival (MSS).There were 1…
Publication
ID32520887Published Date2020-06-09JournalJournal of clinical gastroenterology, 2020-06-09
The goals of this study were to evaluate trends in hospitalizations and in-hospital mortality among US adults with alcohol-associated cirrhosis and alcoholic hepatitis.Alcohol-associated liver disease contributes to significant liver-related morbidity in the United States, among which inpatient care is a major driver of clinical and economic burden.Using the 2007-2014 National Inpatient Sample, alcohol-associated cirrhosis and alcoholic hepatitis hospitalizations were identified. Survey-weigh…
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ID32504466Published Date2020-06-06JournalThe journals of gerontology. Series A, Biological sciences and medical sciences, 2020-06-06
Muscle metrics derived from CT are associated with adverse health events in older persons, but obtaining these metrics using current methods is not practical for large datasets. We developed a fully-automated method for muscle measurement on CT images. This study aimed to determine the relationship between muscle measurements on CT with survival in a large multicenter trial of older adults.The relationship between baseline paraspinous skeletal muscle area (SMA) and skeletal muscle density (SM…
Publication
IDDOI:10.21203/rs.2.10735/v2Published Date2020-06-05
Abstract Background: Renal ultrasounds (RUS) are commonly ordered in hospitalized patients with acute kidney injury (AKI). Clinical decision support tools could be used to inform which patients may benefit from RUS to rule out hydronephrosis, however current risk stratification frameworks are underutilized.Methods: We performed a cross-sectional study of hospitalized adults with AKI at a large, tertiary, academic medical center who had a RUS ordered. We validated an existing risk stratificati…
Publication
ID32492153Published Date2020-06-03JournalThe Journal of clinical endocrinology and metabolism, 2020-06-03
It is unclear whether vitamin D supplementation reduces risk of falls, and results from randomized controlled trials (RCTs) are conflicting.To determine whether 2000 IU/day of supplemental vitamin D3 decreases fall risk.VITamin D and OmegA-3 TriaL (VITAL) is a double-blind, placebo-controlled RCT including 25,871 adults, randomized November 2011-March 2014 and treated for 5.3 years (median).Nationwide study.Men ≥50 and women ≥55 years (mean age 67.1 years) without cancer or cardiovascular dis…
Publication
ID32484533Published Date2020-06-02JournalJAMA, 2020-06-02, Volume 323
Reducing cesarean delivery rates in the US is an important public health goal; despite evidence of the safety of vaginal birth after cesarean delivery, most women have scheduled repeat cesarean deliveries. A decision support tool could help increase trial-of-labor rates.To analyze the effect of a patient-centered decision support tool on rates of trial of labor and vaginal birth after cesarean delivery and decision quality.Multicenter, randomized, parallel-group clinical trial conducted in Bo…
Publication
ID31806883Published Date2020-06-01JournalThe pharmacogenomics journal, 2020-06-01, Volume 20
Hypertension (HTN) is a significant risk factor for cardiovascular morbidity and mortality. Metabolic abnormalities, including adverse cholesterol and triglycerides (TG) profiles, are frequent comorbid findings with HTN and contribute to cardiovascular disease. Diuretics, which are used to treat HTN and heart failure, have been associated with worsening of fasting lipid concentrations. Genome-wide meta-analyses with 39,710 European-ancestry (EA) individuals and 9925 African-ancestry (AA) indi…
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