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Publication
PubMed ID30005946Published Date2018-08-09JournalVaccine, 2018-08-09, Volume 36
Human T-cell leukemia virus type 1 (HTLV-1) has infected as many as 10 million people worldwide. While 90% are asymptomatic, 5% develop severe diseases including adult T-cell leukemia/lymphoka (ATLL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). No vaccine against HTLV-1 exists, and screening programs are not universal. However, patients with chronic HTLV-1 infection have high frequencies of HTLV-1-activated CD8+ T cells, and the two main HLA alleles (A2, A24) are p…
Publication
PubMed ID29793968Published Date2018-08-01JournalJournal of clinical microbiology, 2018-08-01, Volume 56
Detection of acute HIV infection is critical for HIV public health and diagnostics. Clinical fourth-generation antigen (Ag)/antibody (Ab) combination (combo) and p24 Ag immunoassays have enhanced detection of acute infection compared to Ab-alone assays but require ongoing evaluation with currently circulating diverse subtypes. Genetically and geographically diverse HIV clinical isolates were used to assess clinical HIV diagnostic, blood screening, and next-generation assays. Three-hundred-mem…
Publication
PubMed ID29680923Published Date2018-08-01JournalArchives of virology, 2018-08-01, Volume 163
In 2018, the family Arenaviridae was expanded by inclusion of 1 new genus and 5 novel species. At the same time, the recently established order Bunyavirales was expanded by 3 species. This article presents the updated taxonomy of the family Arenaviridae and the order Bunyavirales as now accepted by the International Committee on Taxonomy of Viruses (ICTV) and summarizes additional taxonomic proposals that may affect the order in the near future.
Publication
PubMed ID30063703Published Date2018-07-31JournalPLoS neglected tropical diseases, 2018-07-31, Volume 12
Chikungunya virus (CHIKV) is the most common alphavirus infecting humans worldwide, causing acute and chronically debilitating arthralgia at a great economic expense.To facilitate our study of CHIKV, we generated a mCherry tagged replication-competent chimeric virus, CHIKV 37997-mCherry. Single particle cryoEM demonstrated icosahedral organization of the chimeric virus and the display of mCherry proteins on virus surface. CHIKV 37997-mCherry is attenuated in both IFNαR knockout and wild-type …
Publication
PubMed ID30053640Published Date2018-07-24JournalInfection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases, 2018-07-24, Volume 65
In recent years, relatives (bastrovirus, hepelivirus) of hepeviruses (family Hepeviridae) have been reported in a variety of vertebrate hosts. Preliminary studies indicated that inter-viral family recombination events at the junction of the genomes that encodes non-structural (ORF1) and structural protein (ORF2) were implicated in the genesis of hepeviruses. Using viral metagenomics, next generation sequencing and RT-PCR techniques a genetically divergent hepevirus-like RNA virus was identifi…
Publication
PubMed ID30027669Published Date2018-07-19JournalBritish journal of haematology, 2018-07-19
Approximately 3500 children with sickle cell disease (SCD) are born in Brazil each year, but the burden of SCD morbidity is not fully characterised. A large, multi-centre cohort was established to characterise clinical outcomes in the Brazilian SCD population and create the infrastructure to perform genotype-phenotype association studies. Eligible patients were randomly selected from participating sites and recruited at routine visits. A biorepository of blood samples was created and comprehe…
Publication
PubMed ID30022500Published Date2018-07-18JournalVox sanguinis, 2018-07-18
Platelet concentrates are frequently transfused to patients with reduced immunity. An exhaustive description of their viral content is needed to prevent unwanted infection.To track viral sequences, a shotgun metagenomics approach was used on a bank of 300 platelets concentrates. Sequences were analysed through the diagnostics-oriented pipeline ezVIR.We only observed viruses commonly described in healthy individuals.Herein is reported the first viral landscape of a platelet concentrates bank.
Publication
PubMed ID29773572Published Date2018-07-12JournalBlood, 2018-07-12, Volume 132
Pathogen inactivation of platelet concentrates reduces the risk for blood-borne infections. However, its effect on platelet function and hemostatic efficacy of transfusion is unclear. We conducted a randomized noninferiority trial comparing the efficacy of pathogen-inactivated platelets using riboflavin and UV B illumination technology (intervention) compared with standard plasma-stored platelets (control) for the prevention of bleeding in patients with hematologic malignancies and thrombocyt…
Publication
PubMed ID29989178Published Date2018-07-10JournalTransfusion, 2018-07-10
Obstetric hemorrhage (OH) and access to peripartum blood transfusion remains a global health challenge. The rates of peripartum transfusion in South Africa exceed those in high-income countries despite comparable rates of OH. We sought to evaluate factors associated with peripartum transfusion.A case-control study was conducted at four large South African hospitals. Transfused peripartum women (cases) and nontransfused controls were stratum matched 1:2 by hospital and delivery date. Data on o…
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Research Grants: 105
Publications: 567
Patents: 2
Clinical Trials: 9

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