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Company (351)University (8)Investor (4)Research Institution (3)
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Patent
Publication NumberUS 10415081Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-08-04Publication Date2019-09-17
The invention provides methods and processes for the identification of polymorphisms at one ore more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one ore more mutations within the CFTR gene and the HLA gene complex can be identified.
Patent
Publication NumberUS 10407718Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-04-19Publication Date2019-09-10
Disclosed are methods of multiplexed analysis of oligonucleotides in a sample, including a method of preventing a significant reduction in duplexes detectable in a hybridization assay involving (i) selecting probe lengths for sets of oligonucleotide probes, wherein probes include different subsequences such that at least one subsequence is complementary to a subsequence in a cognate target; wherein probes for longer cognate targets are longer in length than probes for shorter cognate targets,…
Patent
Publication NumberES 2712173 T3Filing StatusOtherAvailabilityUnknownFiling Date2002-10-15Publication Date2019-05-09
The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one or more mutations within the CFTR gene and the HLA gene complex can be identified.
Patent
Publication NumberUS 10202633Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-12-05Publication Date2019-02-12
In a first aspect, there is provided an isolated polypeptide substrate for a disintegrin-like and metallopeptidase with thrombospondin type-1 motif, 13 (ADAMTS13) that is from 45 to 70 amino acids in length and has an amino acid sequence that is substantially similar to part of the von Willebrand factor A2 domain sequence set forth in SEQ ID NO: 2, with one or more of the following modifications: (i) the amino acid corresponding to position 1599 of SEQ ID NO: 2 is mutated from Q to K; (ii) th…
Patent
Publication NumberCA 2741049 CFiling StatusIssued PatentAvailabilityUnknownFiling Date2002-10-15Publication Date2019-02-05
The invention provides methods and processes for the identification of polymorphisms at one or more designated sites, without interference from non-designated sites located within proximity of such designated sites. Probes are provided capable of interrogation of such designated sites in order to determine the composition of each such designated site. By the methods of this invention, one or more mutations within the CFTR gene and the HLA gene complex can be identified.
Patent
Publication NumberUS 20190024156Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-09-25Publication Date2019-01-24
This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays.
Patent
Publication NumberCA 2887401 CFiling StatusIssued PatentAvailabilityUnknownFiling Date2005-10-24Publication Date2019-01-08
Disclosed are a method and an algorithm for genetic cross-matching based on the comparison of recipient and donor genotypes - and the underlying combinations of alleles and haplotypes. The method of the invention, rather than focusing on phenotype prediction, instead relies on a comparison of genetic variants identified in the recipient and available donors, whose information preferably will be compiled in a widely available donor registry, to maximize molecular compatibility The genotypes ca…
Patent
Publication NumberEP 2722395 B1Filing StatusIssued PatentAvailabilityUnknownFiling Date2002-10-15Publication Date2018-12-19
Patent
Publication NumberUS 10138511Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-03-29Publication Date2018-11-27
This invention provides high unit density arrays of microparticles and methods of assembling such arrays. The microparticles in the arrays may be functionalized with chemical or biological entities specific to a given target analyte. The high unit density arrays of this invention are formed on chips which may be combined to form multichip arrays according to the methods described herein. The chips and/or multichip arrays of this invention are useful for chemical and biological assays.
Patent
Publication NumberUS 20180218498Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-03-23Publication Date2018-08-02
Systems and methods are provided the autocentering, autofocusing, acquiring, decoding, aligning, analyzing and exchanging among various parties, images, where the images are of arrays of signals associated with ligand-receptor interactions, and more particularly, ligand-receptor interactions where a multitude of receptors are associated with microparticles or microbeads. The beads are encoded to indicate the identity of the receptor attached, and therefore, an assay image and decoding image a…
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Research Grants: 5
Patents: 345
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