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Patent
Publication NumberUS 20190218247Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-08-14Publication Date2019-07-18
The invention provides methods and systems for production of recombinant protein, and particularly, for production of recombinant protein from inclusion bodies. For example, in one aspect, the method comprises providing a protein preparation comprising inclusion bodies, preparing an inclusion body dispersion, and exposing the protein preparation to high pressure in a pressure vessel, to disaggregate and refold the inclusion body protein.
Patent
Publication NumberBR 112014013369 A2Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2012-12-03Publication Date2017-06-13
The invention provides methods and systems for production of recombinant protein, and particularly, for production of recombinant protein from inclusion bodies. For example, in one aspect, the method comprises providing a protein preparation comprising inclusion bodies, preparing an inclusion body dispersion, and exposing the protein preparation to high pressure in a pressure vessel, to disaggregate and refold the inclusion body protein.
Patent
Publication NumberUS 20160002285Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2014-02-21Publication Date2016-01-07
The present invention provides methods for reducing and/or evaluating the immunogenic potential of a therapeutic protein preparation. The present invention further provides pharmaceutical compositions of therapeutic proteins and methods of treatment with the same, the compositions having low immunogenic potential and/or improved efficacy. The invention achieves these goals by evaluating therapeutic protein preparations for subvisible protein particulates, which can contribute significantly to…
Patent
Publication NumberUS 20150183876Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2014-07-03Publication Date2015-07-02
Methods for refolding antibodies, particularly monoclonal antibodies, from aggregated and/or denatured preparations by subjecting the antibody preparation to high hydrostatic pressure are provided. Refolded preparations of antibodies produced by the methods described herein are also provided.
Patent
Publication NumberUS 20140302589Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2014-05-30Publication Date2014-10-09
The invention provides methods and systems for production of recombinant protein, and particularly, for production of recombinant protein from inclusion bodies. For example, in one aspect, the method comprises providing a protein preparation comprising inclusion bodies, preparing an inclusion body dispersion, and exposing the protein preparation to high pressure in a pressure vessel, to disaggregate and refold the inclusion body protein.
Patent
Publication NumberEP 2785196 A1Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2012-12-03Publication Date2014-10-08
Patent
Publication NumberCN 104080357 AFiling StatusPatent ApplicationAvailabilityUnknownFiling Date2012-12-03Publication Date2014-10-01
The invention provides methods and systems for production of recombinant protein, and particularly, for production of recombinant protein from inclusion bodies. For example, in one aspect, the method comprises providing a protein preparation comprising inclusion bodies, preparing an inclusion body dispersion liquid, and exposing the protein preparation to high pressure in a pressure vessel, to disaggregate and refold the inclusion body protein.
Patent
Publication NumberUS 8802828Filing StatusIssued PatentAvailabilityUnknownFiling Date2012-02-27Publication Date2014-08-12
Methods for refolding antibodies, particularly monoclonal antibodies, from aggregated and/or denatured preparations by subjecting the antibody preparation to high hydrostatic pressure are provided. Refolded preparations of antibodies produced by the methods described herein are also provided.
Patent
Publication NumberUS 8710197Filing StatusIssued PatentAvailabilityUnknownFiling Date2010-11-05Publication Date2014-04-29
The present disclosure provides an effective method for the refolding of denatured proteins in solution so that properly folded, biologically active protein in solution is recovered in high yield. The refolding takes place at pressures between about 0.25 kbar to about 3.5 kbar, advantageously at about 1.5 kbar to about 3 kbar. Typically a chaotropic agent is present at a concentration which is not effective for denaturing protein at atmospheric pressure, and optionally, oxidation-reduction re…
We found 57 documents that match your Search
Research Grants: 1
Patents: 55
SEC Filings: 1

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