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Publication
ID32317592Published Date2020-06-01JournalCritical care medicine, 2020-06-01, Volume 48
To characterize acute alterations of circadian and ultradian rest-activity rhythms in critically ill patients and their association with brain dysfunction, systemic multiple organ dysfunction, and melatonin rhythms.Prospective study observing a cohort for 48 hours beginning within the first day of ICU admission.ICUs within an academic medical center.Patients presenting from the community with acute onset of either intracerebral hemorrhage or sepsis as representative neurologic and systemic cr…
Publication
ID32340861Published Date2020-06-01JournalJournal of vascular and interventional radiology : JVIR, 2020-06-01, Volume 31
To characterize the utility of monitoring transcranial electrical motor evoked potentials (TCeMEPs) and somatosensory evoked potentials (SSEPs) for neural thermoprotection during musculoskeletal tumor ablations.Retrospective review of 29 patients (16 male; median age, 46 y; range, 7-77 y) who underwent musculoskeletal tumor radiofrequency ablation (n = 8) or cryoablation (n = 22) with intraprocedural TCeMEP and SSEP monitoring was performed. The most common tumor histologies were osteoid oste…
Publication
ID31810371Published Date2020-06-01JournalThe Annals of pharmacotherapy, 2020-06-01, Volume 54
To review the literature and recommendations for nonselective β-blockers (NSBBs) in the setting of variceal bleeding prophylaxis and decompensated liver disease. Literature search of MEDLINE was performed (1988 to October 2019) using the following search terms: . Abstracts, peer-reviewed publications, clinical practice guidelines, and product monographs were reviewed. Relevant English language studies and those conducted in humans were considered for analysis and inclusion. Evidence that sugg…
Publication
ID32317599Published Date2020-06-01JournalCritical care medicine, 2020-06-01, Volume 48
The circadian system modulates many important physiologic processes, synchronizing tissue-specific functions throughout the body. We sought to characterize acute alterations of circadian rhythms in critically ill patients and to evaluate associations between brain dysfunction, systemic multiple organ dysfunction, environmental stimuli that entrain the circadian rhythm (zeitgebers), rest-activity rhythms, and the central circadian rhythm-controlled melatonin secretion profile.Prospective study…
Publication
ID32402319Published Date2020-06-01JournalCritical care nursing clinics of North America, 2020-06-01, Volume 32
During critical illness, active discussions about a person's preferences are linked with better patient outcomes. Our intensive care unit implemented an evidence-based standardized communication bundle that included education to providers on effective family communication, focused patient/family discussions to identify Durable Power of Attorney/surrogate decision maker and obtaining advanced directive documents, and documenting conversations in the electronic medical record and appropriately …
Publication
ID32445106Published Date2020-05-22JournalNeurocritical care, 2020-05-22
Therapeutic plasma exchange (TPE) is an extracorporeal process in which a large volume of whole blood is taken from the patient's vein. Plasma is then separated from the other cellular components of the blood and discarded while the remaining blood components may then be returned to the patient. Replacement fluids such as albumin or fresh-frozen plasma may or may not be used. TPE has been used clinically for the removal of pathologic targets in the plasma in a variety of conditions, such as p…
Publication
IDDOI:10.1093/jncics/pkaa042Published Date2020-05-19JournalJNCI Cancer Spectrum, 2020-05-19
ABSTRACT Background Post-menopausal hormone therapy (HT) is associated with a decreased colorectal cancer (CRC) risk. As CRC is a heterogeneous disease, we evaluated whether the association of HT and CRC differs across etiologically-relevant, molecularly-defined tumor subtypes and tumor location. Methods We pooled data on tumor subtypes (microsatellite instability (MSI) status, CpG island methylator phenotype (CIMP) status, BRAF and KRAS mutations, pathway: adenoma-carcinoma, alternate, serra…
Publication
ID32433987Published Date2020-05-17JournalSeminars in thoracic and cardiovascular surgery, 2020-05-17
The peer-reviewed literature is often referenced to generalize outcomes for lung cancer surgeries performed within the Veterans Health Administration (VHA) and include assessments following resection of early stage non-small cell lung cancer. We sought to determine the reliability of these reports that are publicly available. A systematic review was undertaken to identify PubMed indexed articles that report post-operative outcomes following surgical resections for stage I NSCLC within the VHA…
Publication
ID32406785Published Date2020-05-14JournalWestern journal of nursing research, 2020-05-14
A non-randomized single center prospective, descriptive, correlational design was used to determine what end-tidal carbon dioxide (EtCO) level provided the best sensitivity, specificity, and negative predictive value to exclude pulmonary embolism (PE) diagnosis in hemodynamically stable hospitalized adults ( = 111). The financial impact and harm avoidance of adding EtCO to the PE diagnostic process also were examined. PE diagnosis was determined by computed tomography pulmonary angiography (C…
Publication
ID32402061Published Date2020-05-13JournalClinical chemistry, 2020-05-13
The recent emergence of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has resulted in a rapid proliferation of serologic assays. However, little is known about their clinical performance. Here, we compared two commercial SARS-CoV-2 IgG assays.103 specimens from 48 patients with PCR confirmed SARS-CoV-2 infections and 153 control specimens were analyzed using SARS-CoV-2 serologic assays by Abbott and EUROIMMUN (EI). Duration from symptom onset was determined by medical record re…
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