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Publication
ID31773794Published Date2020-04-01JournalDiabetic medicine : a journal of the British Diabetic Association, 2020-04-01, Volume 37
To compare the impact of four surgical procedures (mini-gastric bypass, sleeve gastrectomy, ileal transposition and transit bipartition) vs medical management on gut peptide secretion, β-cell function and resolution of hyperglycaemia in people with type 2 diabetes.A mixed-meal tolerance test was administered 6-24 months after each surgical procedure (mini-gastric bypass, sleeve gastrectomy, ileal transposition and transit bipartition; n=30 in each group) and the results were compared with tho…
Patent
Publication NumberUS 20200093924Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-12-04Publication Date2020-03-26
The CD40L/Mac-1 interaction is selectively targeted by small peptide inhibitors and/or antibodies and such peptides are used for the specific treatment of inflammation and atherogenesis. In particular, pharmaceutical compositions comprising a polypeptide having the amino acid sequence EQLKKSKTL and antibodies specifically binding to an epitope are disclosed.
Patent
Publication NumberUS 20200088747Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-04-09Publication Date2020-03-19
The present invention relates generally to the field of diagnostic and prognostic assays for heart disease. More particular, the present invention provides an assay for diagnosing the presence or extent of development of heart disease or its classification or state thereof. The assay of the present invention is also useful in the stratification of a subject with respect to a risk of developing heart disease. The assay of the present invention is also capable of integration into pathology arch…
Publication
ID32127716Published Date2020-03-04JournalNature medicine, 2020-03-04
People with obesity commonly face a pervasive, resilient form of social stigma. They are often subject to discrimination in the workplace as well as in educational and healthcare settings. Research indicates that weight stigma can cause physical and psychological harm, and that affected individuals are less likely to receive adequate care. For these reasons, weight stigma damages health, undermines human and social rights, and is unacceptable in modern societies. To inform healthcare professi…
Publication
ID31895295Published Date2020-02-05JournalMedicine and science in sports and exercise, 2020-02-05
To identify predictors of favourable changes to postprandial insulin and glucose levels in response to interrupting prolonged sitting time with standing or light intensity physical activity.Data were combined from four similarly designed randomised acute cross-over trials (n=129; BMI range 19.6 to 44.6kg/m2; South Asian=31.0%; dysglycaemia=27.1%). Treatments included: prolonged sitting (6.5hours) or prolonged sitting broken-up with either standing or light-intensity physical activity (5 minut…
Publication
ID32017332Published Date2020-02-03JournalCatheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventions, 2020-02-03
We aimed to assess the outcomes of cardiogenic shock (CS) complicating acute coronary syndromes (ACS).CS remains the leading cause of mortality in patients presenting with ACS despite advances in care.We studied 13,184 patients undergoing percutaneous coronary intervention (PCI) for all subtypes of ACS enrolled prospectively in a large multicentre Australian registry (Melbourne Interventional Group registry) from 2005 to 2013. All-cause mortality was obtained via linkage to the National Death…
Publication
ID31971904Published Date2020-01-01JournalJACC. Clinical electrophysiology, 2020-01-01, Volume 6
The goal of this study was to describe functional endocardial-epicardial dissociation (FEED), signal complexities, and three-dimensional activation dynamics of the human atrium with structural heart disease (SHD).SHD commonly predisposes to arrhythmias. Although progressive remodeling is implicated, direct demonstration of FEED in the human atrium has not been reported previously.Simultaneous intraoperative mapping of the endocardial and epicardial lateral right atrial wall was performed by u…
Publication
ID31791086Published Date2020-01-01JournalInternational journal of sports medicine, 2020-01-01, Volume 41
Several athletic programs incorporate echocardiography during pre-participation screening of American Style Football (ASF) players with great variability in reported echocardiographic values. Pre-participation screening was performed in National Collegiate Athletic Association Division I ASF players from 2008 to 2016 at the Division of Sports Cardiology. The echocardiographic protocol focused on left ventricular (LV) mass, mass-to-volume ratio, sphericity, ejection fraction, and longitudinal …
Publication
ID31832833Published Date2019-12-12JournalHeart failure reviews, 2019-12-12
Conclusive evidence demonstrates that the sympathetic nervous system activation is a hallmark of congestive heart failure. This has been shown via a variety of biochemical, neurophysiological, and neuroimaging approaches for studying human sympathetic neural function. The sympathetic activation appears to be an early phenomenon in the clinical course of the disease, closely related to its severity and potentiated by the concomitant presence of other comorbidities, such as obesity, diabetes me…
Publication
ID31655774Published Date2019-12-01JournalEndocrinology and metabolism clinics of North America, 2019-12-01, Volume 48
Pseudopheochromocytoma manifests as severe, symptomatic paroxysmal hypertension without significant elevation in catecholamine and metanephrine levels and lack of evidence of tumor in the adrenal gland. The clinical manifestations are similar but not identical to those in excess circulating catecholamines. The underlying symptomatic mechanism includes augmented cardiovascular responsiveness to catecholamines alongside heightened sympathetic nervous stimulation. The psychological characteristi…
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