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Research Grant
Project Number1R44GM125469-01Funding AgencyNational Institutes of HealthEffective Date2017-08-01Expiration Date2018-07-31Funding Amount$1,016,149
PROJECT SUMMARY Drug-induced liver injury (DILI) is the main reason for drug attrition during development and a leading cause of post-market drug withdrawal. Here, we propose a systems biology approach to detect drug candidates with DILI liabilities at early stages of development. This approach is based on the assessment of drug-induced perturbations of multiple signal transduction pathways in hepatocytic cells. For that, we use Attagene multiplexed reporter technology, the FACTORIAL?,that en…
Patent
Publication NumberEP 2748338 B1StatusIssued PatentAvailabilityUnknownFiling Date2012-09-08Publication Date2017-04-26
Patent
Publication NumberEP 3094750 A1StatusPatent ApplicationAvailabilityUnknownFiling Date2015-01-09Publication Date2016-11-23
A protein reporter system comprising at least one reporter including a response element responsive to the binding of a transcription factor, a secreted enzyme backbone and a recognition region for specific binding of an antibody. Multiplexed assays for binding, assaying and quantifying the activity of transcription factors are also described, in which the assays use protein reporters in sets, libraries or other groupings, as necessary to achieve desired quantification.
Patent
Publication NumberUS 20160333428StatusPatent ApplicationAvailabilityUnknownFiling Date2015-01-09Publication Date2016-11-17
A protein reporter system comprising at least one reporter including a response element responsive to the binding of a transcription factor, a secreted enzyme backbone and a recognition region for specific binding of an antibody. Multiplexed assays for binding, assaying and quantifying the activity of transcription factors are also described, in which the assays use protein reporters in sets, libraries or other groupings, as necessary to achieve desired quantification.
Patent
Publication NumberEP 1945795 B1StatusIssued PatentAvailabilityUnknownFiling Date2006-09-27Publication Date2016-08-10
Patent
Publication NumberCA 2623795 CStatusIssued PatentAvailabilityUnknownFiling Date2006-09-27Publication Date2016-06-14
This application provides methods of determining biological activities of a biological sample comprising, for example, comparing the profile of transcription factor activities in a cell contacted with the biological sample to a control profile, such as a profile of transcription factor activities in a cell not contacted with the biological sample.
Patent
Publication NumberEP 1817433 B1StatusIssued PatentAvailabilityUnknownFiling Date2005-11-10Publication Date2016-04-20
Patent
Publication NumberCA 2587338 CStatusIssued PatentAvailabilityUnknownFiling Date2005-11-10Publication Date2016-02-09
Patent
Publication NumberWO 2007038756 A9StatusPatent ApplicationAvailabilityUnknownFiling Date2006-09-27Publication Date2015-10-15
This application provides methods of determining biological activities of a biological sample comprising, for example, comparing the profile of transcription factor activities in a cell contacted with the biological sample to a control profile, such as a profile of transcription factor activities in a cell not contacted with the biological sample.
Patent
Publication NumberUS 20140323341StatusPatent ApplicationAvailabilityUnknownFiling Date2012-09-08Publication Date2014-10-30
A method of determining biosimilarity of a sample composition to a reference composition, including: exposing a test cell system to a sample composition so that the test cell system responds to the sample composition by change in transcription factor activity in the test cell system; generating from the test cell system response an output correlative to the change of transcription factor activity in the test cell system; and determining from comparison of said output with a transcription fact…