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Web Document
Date Added2020-02-29
SYNTHETIC LETHALITY - Atlantic Cancer Research Institute Français Research Streams SYNTHETIC LETHALITY An approach called synthetic lethality targets biological systems in which two or more genetic pathways interact to contribute to a vital cellular process. The loss of either pathway does not threaten cell viability and may indeed provide a survival advantage, such as the case with cancer cells; however, lethality is observed when both pathways are inhibited, which may be achieved using spec…
Web Document
Date Added2020-02-29
PROTEOMICS & MASS SPECTOMETRY - Atlantic Cancer Research Institute Français Research Streams PROTEOMICS & MASS SPECTOMETRY Mass spectrometry is a technique that permits the identification of a particular protein based on a known fingerprint for that protein. Many of the ongoing projects at ACRI rely on the ability to identify proteins on a large scale (a science known as proteomics), specifically our extracellular vesicle project and our investigations of gene pathways and regulation. Dr. Dav…
Web Document
Date Added2020-02-29
GENE PATHWAYS & REGULATION - Atlantic Cancer Research Institute Français Research Streams GENE PATHWAYS & REGULATION Several ACRI scientists are working on understanding the mechanisms that underlie the key cellular activities that are important for cancer cell growth. Our researchers are currently investigating the regulation of gene expression and how this is changed in cancer cells, with specific focuses on metastatic breast cancer and kidney cancer. In addition, our researchers are design…
Web Document
Date Added2020-02-29
BIOMARKER DISCOVERY - Atlantic Cancer Research Institute Français Research Streams BIOMARKER DISCOVERY ACRI scientists are looking for the 'red flags' that identify a cancer cell (so-called "biomarkers") using cDNA microarray technology (AMF) and Next-Generation Sequencing, which permits the identification of cancer-specific genes due to changes in their levels in cancer cells versus normal cells, or in cancer patients versus healthy individuals Using an approach known as bioinformatics, ACRI…
Web Document
Date Added2020-02-29
MICROWAVE-ASSISTED TUMOUR ABLATION - Atlantic Cancer Research Institute Français Research Streams MICROWAVE-ASSISTED TUMOUR ABLATION The ACRI medical technologies research team, recipients of an NBIF Research Chair, is investigating the use of microwaves as an energy source for the detection and treatment of cancer. This research subject is a core disruptive technology that will lead to the development of new, non-invasive treatments and more precise screening methods in the detection of canc…
Web Document
Date Added2020-02-29
LIQUID BIOPSY - Atlantic Cancer Research Institute Français Research Streams LIQUID BIOPSY The ACRI team is working to identify the specific proteins and nucleic acids that are released from cancer cells in small packages known as exosomes and/or microvesicles (collectively known as extracellular vesicles - EVs). By using novel, proprietary technologies developed at ACRI, ACRI scientists are able to rapidly and efficiently capture extracellular vesicles from both cell culture and body fluids …
Web Document
Date Added2020-02-28
Donations - Atlantic Cancer Research Institute Français Donations Donations Our online donations are managed by the CHU Dumont Foundation. To make an online donation to ACRI please follow the link below with the following instructions: Click on the Canada Helps link below Choose to apply the donation to the specific fund: Cancer research - ACRI Continue with your donation https://www.canadahelps.org/en/charities/dr-georges-l-dumont-hospital-foundation/ If you would like to make a donation by …
Web Document
Date Added2020-02-28
Research Streams - Atlantic Cancer Research Institute Français Research Streams The ACRI fosters a collaborative environment among its research scientists that favors discovery. Through their efforts our researchers are gaining a better understanding of cancer cells and the factors that distinguish them from normal cells. Through this approach, ACRI scientists are determining which factors are altered in cancer cells in order to find innovative methods for cancer detection and treatment. Ulti…
Patent
Publication NumberUS 10488403Filing StatusIssued PatentAvailabilityUnknownFiling Date2013-07-19Publication Date2019-11-26
The present disclosure relates to a method for the isolation of microvesicles comprising contacting the sample with at least one polysaccharide to isolate the microvesicles.
Publication
ID31743393Published Date2019-11-26JournalBlood advances, 2019-11-26, Volume 3
Multiple myeloma (MM) is an incurable blood cancer that is often characterized by amplification and overexpression of the MYC oncogene. Despite efforts, direct targeting of MYC is not yet possible; therefore, alternative strategies to inhibit MYC activity are necessary. TAZ is a transcriptional coactivator downstream of the Hippo-signaling pathway that functions as an oncogene in many solid tumors. However, its role in hematological malignancies is largely unexplored. Here, we show that, in c…
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