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Patent
Publication NumberUS 10556860Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-11-30Publication Date2020-02-11
The present invention provides hTERT modulators and methods for producing and using the same. In particular, the present invention provide a compound of the formula as described herein. Some aspects of the invention are based on the characterization of the effect of hTERT core promoter region mutants on the 5-12 G-quadruplex structure and its stability. It is believed that some of the compounds of the invention bind selectively to the G-quadruplex in the hTERT core promoter mutant, which resu…
Patent
Publication NumberUS 20190388545Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-06-21Publication Date2019-12-26
The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of ant…
Patent
Publication NumberUS 10496409Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-11-21Publication Date2019-12-03
Systems and methods for prioritizing executions of a plurality of instructions in a computer system (such as an embedded system) are disclosed. An instruction can be associated with a priority and an atomicity. When an instruction is fetched, the computer system can access the priority and atomicity information together with the accessing the operand and decoding the instruction. The instruction may be executed in accordance with the fetched priority and atomicity. In some situations, the plu…
Patent
Publication NumberUS 10463856Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-06-13Publication Date2019-11-05
Some embodiments include a dipolar antenna system to electrically power an implantable miniature device and/or to stimulate bioelectrically excitable tissue, such as, for example, through microelectronic neurostimulation. Other related systems and methods are also disclosed.
Patent
Publication NumberUS 10449254Filing StatusIssued PatentAvailabilityUnknownFiling Date2014-11-03Publication Date2019-10-22
The compositions and methods described herein are topically applied to the skin with negligible or no skin irritation and can direct or prevent transport through the skin. The compositions contain neat ionic liquids, optionally in combination with a drug to be delivered. In a preferred embodiment, the compositions increase transdermal transport of the drug to be delivered. In some embodiments, the compositions disrupt bacterial biofilms. This is particularly beneficial in the treatment of ant…
Patent
Publication NumberUS 10446582Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-10-25Publication Date2019-10-15
A method can include providing a scintillator structure. Providing the scintillator structure can include providing a scintillator support layer, providing a scintillator layer, and coupling the scintillator layer to the scintillator support layer. Meanwhile, the scintillator support layer has a substantially non-planar surface, the scintillator layer having a first surface and a second surface opposite the first surface and being configured to scintillate, and the first surface of the scinti…
Patent
Publication NumberUS 10433036Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-12-21Publication Date2019-10-01
Implementations of data logger systems may include: a data logger coupled with an energy storage device. The data logger may be configured to couple to a living subject and record data related to one of the living subject's activities and a vital parameter of the living subject. The data logger system may also include an energy harvester electrically coupled with the energy storage device, where the energy harvester is configured to harvest energy from one of an external environment, the livi…
Patent
Publication NumberUS 10427125Filing StatusIssued PatentAvailabilityUnknownFiling Date2012-05-04Publication Date2019-10-01
Provided are methods for performing patterned chemistry and arrays prepared thereby.
Patent
Publication NumberUS 10422793Filing StatusIssued PatentAvailabilityUnknownFiling Date2012-09-21Publication Date2019-09-24
The invention provides arrays of compound for use in profiling samples. The arrays include compounds bind to components of the samples at relatively low affinities. The avidity of compounds binding to components of the samples can be increased by forming arrays such that multivalent components of the samples (e.g., antibodies or cells) can bind to more than one molecule of a compound at the same time. When a sample is applied to an array under such conditions, the compounds of the array bind …
Patent
Publication NumberTW I671832 BFiling StatusIssued PatentAvailabilityUnknownFiling Date2015-05-11Publication Date2019-09-11
Some embodiments include a method. The method can comprise: providing a carrier substrate; providing an adhesion modification layer over the carrier substrate; providing a device substrate; and coupling the device substrate and the carrier substrate together, the adhesion modification layer being located between the device substrate and the carrier substrate when the device substrate and the carrier substrate are coupled together. In these embodiments, the adhesion modification layer can be c…
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