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ID31582169Published Date2019-11-01JournalCellular immunology, 2019-11-01, Volume 345
Previous in vivo studies established that inactivated Francisella tularensis immune complexes (mAb-iFt) are a more protective vaccine against lethal tularemia than iFt alone. Subsequent in vitro studies revealed enhanced DC maturation marker expression with mAb-iFt stimulation. The goal of this study was to determine the mechanism of enhanced DC maturation. Multiparameter analysis of surface marker expression and cytokine secretion demonstrates a requirement for FcγR signaling in enhanced DC …
Publication
ID31131629Published Date2019-11-01JournalJournal of cardiovascular pharmacology and therapeutics, 2019-11-01, Volume 24
Lipoprotein-associated phospholipase A (LpPLA) is an inflammatory marker that has been associated with the presence of vulnerable plaque and increased risk of cardiovascular (CV) events.To assess the effect of extended-release niacin (ERN) on Lp-PLA activity and clinical outcomes.We performed a post hoc analysis in 3196 AIM-HIGH patients with established CV disease and low baseline levels of high-density lipoprotein cholesterol (HDL-C) who were randomized to ERN versus placebo on a background…
Publication
ID31674681Published Date2019-11-01JournalPacing and clinical electrophysiology : PACE, 2019-11-01
Implantable cardioverter-defibrillator (ICD) recipients who receive appropriate device therapies have limited survival, and survival benefit in chronic kidney disease (CKD) has been questioned. We examined the association between CKD and survival after cardiac resynchronization therapy (CRT)-defibrillator tachyarrhythmia therapies.We compared overall survival after appropriate shocks or anti-tachycardia pacing in 439 CRT-defibrillator recipients with LVEF ≤35%, non-right bundle-branch block Q…
Publication
ID31675419Published Date2019-11-01JournalThe Journal of clinical endocrinology and metabolism, 2019-11-01
Abstract not available
Publication
ID30676517Published Date2019-11-01JournalThe Journal of the American Academy of Orthopaedic Surgeons, 2019-11-01, Volume 27
There is paucity of literature evaluating anterior acetabular retractor proximity to the femoral nerve and external iliac vessels during total hip arthroplasty through the direct anterior approach. In this cadaveric study, we evaluated three retractor locations to identify optimal positioning of anterior retractors.A direct anterior approach was performed in 22 hips of 15 cadavers. Anterior acetabular retractors were placed over the anterior acetabular wall in-line with the femoral neck (12-o…
Publication
ID31675955Published Date2019-11-01JournalHuman resources for health, 2019-11-01, Volume 17
The 2014-2016 Ebola epidemic in West Africa placed greater demands on the affected countries' already scarce health workforce. Consequently, governments in the most affected West African countries made appeals for volunteers to join Ebola response programs. Those volunteers played an important yet high-risk role in aiding the victims of the Ebola epidemic and in limiting its spread. However, little is known as to what motivated those volunteers to commit themselves to the Ebola response progr…
Publication
ID31518169Published Date2019-11-01JournalAmerican journal of physiology. Heart and circulatory physiology, 2019-11-01, Volume 317
Multifunctional Ca/calmodulin-dependent protein kinase II (CaMKII) is a multigene family with isoform-specific regulation of vascular smooth muscle (VSM) functions. In previous studies, we found that vascular injury resulted in VSM dedifferentiation and reduced expression of the CaMKIIγ isoform in medial wall VSM. Smooth muscle knockout of CaMKIIγ enhanced injury-induced VSM neointimal hyperplasia, whereas CaMKIIγ overexpression inhibited VSM proliferation and neointimal formation. In this st…
Publication
ID30922774Published Date2019-11-01JournalPediatric neurology, 2019-11-01, Volume 100
Abstract not available
Publication
ID30882511Published Date2019-11-01JournalDermatologic surgery : official publication for American Society for Dermatologic Surgery [et al.], 2019-11-01, Volume 45
Nonsurgical skin-tightening procedures are increasing in popularity, as patients seek aesthetic interventions that are safe with minimal downtime.This study was designed to provide precise data on the depth of the superficial fascia-the structure of action-of the face and neck.One hundred fifty Caucasian individuals (75 men and 75 women) were investigated with a balanced distribution of age (n = 30 per decade: 20-29, 30-39, 40-49, 50-59, and 60-69 years) and body mass index (BMI) (n = 50 per …
Publication
ID31499123Published Date2019-11-01JournalFood and chemical toxicology : an international journal published for the British Industrial Biological Research Association, 2019-11-01, Volume 133
The obesity-regulated gene, leptin, is essential for diet. Leptin resistance causes obesity and related diseases. Certain types of diet are able to decrease leptin resistance. However, leptin has been shown to be correlated with inflammation and stimulate proliferation of various cancers. Two synthetic leptin derivatives (mimetics), OB3 and [D-Leu-4]-OB3, show more effective than leptin in reducing obesity and diabetes in mouse models. OB3 inhibits leptin-induced proliferation in ovarian canc…
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