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Publication
ID30898672Published Date2019-07-15JournalBrain research, 2019-07-15, Volume 1715
Chronic pain is the most common non-motor symptom among Parkinson's disease (PD) patients, with 1.85 million estimated to be in debilitating pain by 2030. Subthalamic deep brain stimulation (STN DBS) programmed for treating PD motor symptoms has also been shown to significantly improve pain scores. However, even though most patients' pain symptoms improve or disappear, 74% of patients treated develop new pain symptoms within 8 years. Previously we have shown that duloxetine and STN high frequ…
Publication
ID31153968Published Date2019-08-01JournalAntiviral research, 2019-08-01, Volume 168
Chronic hepatitis B virus (HBV) infections cause more than 800,000 deaths per year and currently approved treatments do not cure the disease. Because a hallmark of acute infection resolution is the presence of functional CD8 T cells to the virus, activation of the immune system with therapeutic vaccines represents a potential approach for treating chronic hepatitis B. In this study, we evaluated the immunogenicity and efficacy of two attenuated vesiculovirus-based platforms expressing HBV Cor…
Publication
ID31128137Published Date2019-08-01JournalLife sciences, 2019-08-01, Volume 230
Exercise programs have been shown to be effective for both reducing risk for, and intervention following, substance abuse behaviors in both clinical and preclinical studies. Less is known, however, regarding the underlying neurobiological substrates involved in these changes in drug seeking behavior. In this study, we assessed cannabinoid receptor (CB1) levels throughout the brain which are key in endocannabinoid signaling following chronic aerobic exercise.Male and female Lewis young adult r…
Publication
ID31282607Published Date2019-07-08JournalJournal of cosmetic dermatology, 2019-07-08
Soft tissue filler injections are performed using either sharp-tip needles or blunt-tip cannulas. Product can change planes in an uncontrolled manner during needle injections, potentially leading to unintentional intra-arterial placement. There is a paucity of data on the influence of injection angle on the dispersion patterns of soft tissue fillers.A total of 126 injection procedures were conducted in seven Caucasian body donors (four males, three females) with a mean age of 75.29 ± 4.95 yea…
Publication
ID31282119Published Date2019-07-08JournalJournal of cosmetic dermatology, 2019-07-08
Neuromodulator injections of the forehead are often performed using standardized protocols. This study was designed to identify the individual skin motion pattern of the forehead and to relate this pattern to the underlying frontalis muscle morphology to offer guidance for neuromodulator placement.Thirty-seven healthy volunteers (29 Caucasians, six African Americans, two Asians) with a mean age of 39.84 ± 14.4 years [range: 22-73] were enrolled. 3D images of the forehead were analyzed using a…
Publication
ID31284746Published Date2019-07-06JournalFASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2019-07-06
Chronic kidney disease affects >15% of the U.S. population and >850 million individuals worldwide. Fibrosis is the common outcome of many chronic renal disorders and, although the etiology varies (, diabetes, hypertension, ischemia, acute injury, and urologic obstructive disorders), persistently elevated renal TGF-β1 levels result in the relentless progression of fibrotic disease. TGF-β1 orchestrates the multifaceted program of renal fibrogenesis involving proximal tubular dysfunction, failed…
Publication
ID31270179Published Date2019-07-03JournalJournal of clinical microbiology, 2019-07-03
Conventional methodology for gastrointestinal pathogens remains time-consuming, expensive, and of limited sensitivity. Performance evaluation of the BD MAX Enteric Viral Panel (MAX EVP) assay for identification of viral pathogens in stool specimens from individuals with symptoms of acute gastroenteritis, enteritis, or colitis.: Prospective and archival stool specimens were collected in Cary-Blair medium or unpreserved containers from adult and pediatric patients with diarrhea. Specimens teste…
Publication
ID31268735Published Date2019-07-03JournalAJR. American journal of roentgenology, 2019-07-03
Given recent specialty attention to workforce diversity, we aimed to characterize potential gender differences in the practice patterns of interventional radiologists (IRs). Using Medicare claims data, we identified IRs on the basis of the distribution of their billed clinical work effort and descriptively characterized practice patterns by gender. Women represented 8.2% (241/2936) of all IRs identified nationally. Female representation varied geographically (≤ 2% in nine states, ≥ 20% in thr…
Publication
ID31264907Published Date2019-07-02JournalAmerican journal of respiratory cell and molecular biology, 2019-07-02
High CO2 retention, or hypercapnia, is associated with worse outcomes in patients with chronic pulmonary diseases. Skeletal muscle wasting is also an independent predictor of poor outcomes in patients with acute and chronic pulmonary diseases. While previous evidence indicates that high CO2 accelerates skeletal muscle catabolism via AMPK-FoxO3a-MuRF1, little is known about the role of high CO2 in regulating skeletal muscle anabolism. In the present study we investigated the potential role of …
Publication
ID31211830Published Date2019-07-02JournalClinical infectious diseases : an official publication of the Infectious Diseases Society of America, 2019-07-02, Volume 69
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