15
15
19
19
13
13
40
40
42
42
50
50
50
50
48
48
41
41
17
17
2020
2011
University (604)Research Institution (17)Hospital (3)Other (2)Foundation (1)
1 - 10 of 604
Sort by
Publication
ID32610072Published Date2020-06-28JournalNanomedicine : nanotechnology, biology, and medicine, 2020-06-28
Vaccine developmental strategies are utilizing antigens encapsulated in biodegradable polymeric nanoparticles. Here, we developed a Chlamydia nanovaccine (PLGA-rMOMP) by encapsulating its recombinant major outer membrane protein (rMOMP) in the extended-releasing and self-adjuvanting PLGA [poly (D, L-lactide-co-glycolide) (85:15)] nanoparticles. PLGA-rMOMP was small (nanometer size), round and smooth, thermally stable, and exhibited a sustained release of rMOMP. Stimulation of mouse primary de…
Publication
IDDOI:10.1155/2020/7461742Published Date2020-06-24JournalMediators of Inflammation, 2020-06-24, Volume 2020
The immunopathology of chlamydial diseases is exacerbated by a broad-spectrum of inflammatory mediators, which we reported are inhibited by IL-10 in macrophages. However, the chlamydial protein moiety that induces the inflammatory mediators and the mechanisms by which IL-10 inhibits them are unknown. We hypothesized that Chlamydia major outer membrane protein (MOMP) mediates its disease pathogenesis, and the suppressor of cytokine signaling (SOCS)1 and SOCS3 proteins are mediators of the IL-1…
Publication
IDCSHL:2020.06.05.136614Published Date2020-06-05JournalbioRxiv, 2020-06-05
Plant growth and development involves an intricate program of cell division and cell expansion to generate different cell types, tissue patterns and organ shapes. Plant cells are stuck together by their cell walls and the spatial context of cells within tissues plays a critical role in cell fate specification and morphogenesis. An in vitro model system to study plant development and its regulation by various extrinsic and intrinsic factors requires the ability to mimic the physical interactio…
Research Grant
Project Number5R25GM106995-07Funding AgencyNational Institutes of HealthEffective Date2020-06-01Expiration Date2021-05-31Funding Amount$294,070
Summary Alabama State University (ASU) is renewing its NIGMS-RISE program. The major objective of the program is to increase the number of underrepresented minority students (URM) enrolling in PhD programs in biomedical sciences. This renewal is significant, since the NIGMS-RISE program is the only program at ASU that provides research training and PhD preparedness students in the MS program in biology with the highest potential of entering PhD programs. With this rationale, our NIGMS-RISE pr…
Publication
ID32492617Published Date2020-05-24JournalJournal of hazardous materials, 2020-05-24, Volume 398
Tebuconazole is a widely used fungicide that may impair soil health. Presently, limited information is available on the bioremediation of tebuconazole-contaminated soil using biochar as a carrier for bacteria. In this study, we firstly isolated a tebuconazole-degrading strain and identified it as Alcaligenes faecalis WZ-2. Then, we used wheat straw-derived biochar as carrier to capture strain WZ-2 to assemble microorganism-immobilized composite. Finally, we investigated the effects of strain …
Research Grant
Project Number1SC3GM132027-01A1Funding AgencyNational Institutes of HealthEffective Date2020-05-01Expiration Date2021-02-28Funding Amount$97,756
PROJECT SUMMARY: We propose to investigate a novel epitope mapping approach of SARS-CoV S proteins, using RNA phage Q? displayed peptides, and to evaluate the potential of these engineered hybrid phages as antibody neutralizing determinants critically important in the development of an efficacious vaccine candidate. Among the proteins coded by the SARS-CoV genome, S protein mediates its cell entry and induces neutralizing antibodies. These pivotal functions are achieved by key amino acid pept…
Publication
ID32319725Published Date2020-04-22JournalJournal of biomedical materials research. Part A, 2020-04-22
Gelatin, as a common hemostatic agent, has been processed into a variety of forms for clinical applications. To enhance wound healing and reduce postoperative complications after liver trauma or surgery, naturally-derived materials can be incorporated into gelatin to improve its physical and biological properties. In this study, we developed an extracellular matrix (ECM) enriched gelatin (EG) sponge through combining liver ECM digestion and gelatin at different proportions. By increasing the …
Publication
ID32313164Published Date2020-04-20JournalScientific reports, 2020-04-20, Volume 10
Thanatotranscriptome studies involve the examination of mRNA transcript abundance and gene expression patterns in the internal organs of deceased humans. Postmortem gene expression is indicative of the cellular status of a corpse at the time of death, a portion of which may represent a cascade of molecular events occasioned by death. Specific gene biomarkers identify perceptible transcriptional changes induced by stochastic responses to the cessation of biological functions. Transcriptome ana…
Publication
IDCSHL:2020.04.17.046367Published Date2020-04-17JournalbioRxiv, 2020-04-17
Extracellular vesicles (EVs) play a fundamental role in cell and infection biology and have the potential to act as biomarkers for novel diagnostic tools. In this study, we explored the in vitro impact of bacterial lipopolysaccharide administration on a cell line that represents a target for bacterial infection in the host. Administration of lipopolysaccharide at varying concentrations to this A549 cell line caused only modest changes in cell death, but EV numbers were significantly changed. …
Publication
ID31958726Published Date2020-04-15JournalThe Science of the total environment, 2020-04-15, Volume 713
Acid rain has been one of the major environmental problems in industrial countries. While it may affect the litter decomposition, a highly important microbial-driven biogeochemical process, knowledge about the impact of acid rain on litter-decomposing microbial communities and their functions remains unclear. Therefore, this experiment was conducted to investigate how acid rain treatments would alter microbial communities and their functions during litter decomposition of three major commodit…
We found 604 documents that match your Search
Research Grants: 218
Publications: 383
Patents: 3

Wellspring Search is the world's most comprehensive collection of enriched content about emerging and licensable technology innovations.


Already a member? Sign in