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Publication
ID31250422Published Date2019-07-20JournalThe Tokai journal of experimental and clinical medicine, 2019-07-20, Volume 44
The newer generation non selective vasodilating beta adrenergic blocking agent Carvedilol, also has an alpha 1 adrenoceptor antagonistic effect and is widely used in treating various cardiovascular diseases. It is a selective alpha and non-selective beta blocker. It's side effects are vast and not limited to any particular organ system, the neuropsychiatric adverse effects include; somnolence, nervousness, sleep disorder, aggravated depression, vivid dreams, delirium, psychosis, impaired conc…
Salisu A Aikoye Mohammad Jafferany Vanessa Osuagwu Dianne L Plath
University College DublinUniversity College DublinCentral Michigan UniversityCentral Michigan University
Publication
ID31164224Published Date2019-07-19JournalJournal of biomechanics, 2019-07-19, Volume 92
Post-mortem human subjects (PMHS) are frequently used to characterize biomechanical response and injury tolerance of humans to various types of loading by means of instrumentation installed directly on the skeleton. Data extracted from such tests are often used to develop and validate anthropomorphic test devices (ATDs), which function as human surrogates in tests for injury assessment. Given that the location and orientation of installed instrumentation differs between subjects, nominally si…
University of MichiganUniversity of MichiganMedical College of WisconsinMedical College of WisconsinUnited States ArmyUnited States ArmyOhio State UniversityOhio State UniversityWayne State UniversityWayne State Universityshow 2 more
Publication
ID31286826Published Date2019-07-16JournalJournal of the American Heart Association, 2019-07-16, Volume 8
Background Exposure to air pollution from solid fuel used in residential cookstoves is considered a leading environmental risk factor for disease globally, but evidence for this relationship is largely extrapolated from literature on smoking, secondhand smoke, and ambient fine particulate matter ( PM ). Methods and Results We conducted a controlled human-exposure study (STOVES [the Subclinical Tests on Volunteers Exposed to Smoke] Study) to investigate acute responses in blood pressure follow…
Kristen M Fedak Nicholas Good Ethan S Walker John R Balmes R D Brookshow 10 more
Colorado State UniversityColorado State UniversityUniversity of California San Francisco (UCSF)University of California San Francisco (UCSF)University of California SystemUniversity of California SystemUniversity of MichiganUniversity of Michigan
Publication
ID31288681Published Date2019-07-26JournalBiology letters, 2019-07-26, Volume 15
Abstract not available
Bernhard Fink Marina L Butovskaya Todd K Shackelford
Russian Academy of SciencesRussian Academy of SciencesOakland UniversityOakland University
Publication
ID31189572Published Date2019-07-15JournalJournal of immunology (Baltimore, Md. : 1950), 2019-07-15, Volume 203
Aminopeptidase N/CD13 is expressed by fibroblast-like synoviocytes (FLS) and monocytes (MNs) in inflamed human synovial tissue (ST). This study examined the role of soluble CD13 (sCD13) in angiogenesis, MN migration, phosphorylation of signaling molecules, and induction of arthritis. The contribution of sCD13 was examined in angiogenesis and MN migration using sCD13 and CD13-depleted rheumatoid arthritis (RA) synovial fluids (SFs). An enzymatically inactive mutant CD13 and intact wild-type (W…
Publication
ID31121533Published Date2019-07-15JournalJournal of the neurological sciences, 2019-07-15, Volume 402
Atrial fibrillation (AF) increases the risk of thromboembolism. Atrial cardiopathy, defined as structural left atrial enlargement (LAE), has been proposed to be a unifying risk factor for stroke, with or without atrial fibrillation (AF). We sought to understand the relative importance of LAE and AF as risk factors for stroke.We performed a retrospective analysis of all patients who underwent echocardiography within the Henry Ford Health System between March and September 2016. Patients were c…
Muhammad Affan Abhimanyu Mahajan Sumul Modi Lonni Schultz Angelos Katramadosshow 2 more
Henry Ford Health SystemHenry Ford Health SystemUniversity of CincinnatiUniversity of CincinnatiWayne State UniversityWayne State University
Publication
ID31034598Published Date2019-07-15JournalCancer, 2019-07-15, Volume 125
Ontuxizumab, a humanized monoclonal antibody, targets endosialin (tumor endothelial marker 1 [TEM-1] or CD248), which is expressed on sarcoma cells and is believed to be involved in tumor angiogenesis. This is the first trial to evaluate ontuxizumab in patients with sarcoma.Part 1 was an open-label, dose-finding, safety lead-in: 4, 6, or 8 mg/kg with gemcitabine and docetaxel (G/D; 900 mg/m gemcitabine on days 1 and 8 and 75 mg/m docetaxel on day 8). In part 2, patients were randomized in a d…
Robin L Jones Sant P Chawla Steven Attia Patrick Schoffski Hans Gelderblomshow 12 more
Mayo ClinicMayo ClinicLeiden UniversityLeiden UniversityUniversity of California Los Angeles (UCLA)University of California Los Angeles (UCLA)University of California SystemUniversity of California SystemWashington University in St LouisWashington University in St Louisshow 8 more
Publication
ID30858296Published Date2019-07-15JournalJournal of bacteriology, 2019-07-15, Volume 201
The phage shock protein (Psp) system is a stress response pathway that senses and responds to inner membrane damage. The genetic components of the Psp system are present in several clinically relevant Gram-negative bacteria, including However, most of the current knowledge about the Psp response stems from studies in and In fact, the Psp response in has remained completely uncharacterized. In this study, we demonstrate that does have a functional Psp response system. We found that overexpress…
Cara M Deangelis Dhrubajyoti Nag Jeffrey H Withey Jyl S Matson
University of ToledoUniversity of ToledoWayne State UniversityWayne State University
Publication
ID31043527Published Date2019-07-15JournalJournal of virology, 2019-07-15, Volume 93
Porcine reproductive and respiratory syndrome virus (PRRSV) blocks host mRNA nuclear export to the cytoplasm, and nonstructural protein 1 beta (nsp1β) of PRRSV has been identified as the protein that disintegrates the nuclear pore complex. In the present study, the molecular basis for the inhibition of host mRNA nuclear export was investigated. Nucleoporin 62 (Nup62) was found to bind to nsp1β, and the region representing the C-terminal residues 328 to 522 of Nup62 was determined to be the bi…
Hanzhong Ke Mingyuan Han Jineui Kim Kurt E Gustin Dongwan Yoo
University of Illinois at Urbana-ChampaignUniversity of Illinois at Urbana-ChampaignUniversity of MichiganUniversity of MichiganUniversity of ArizonaUniversity of Arizona
Publication
ID31043528Published Date2019-07-15JournalJournal of virology, 2019-07-15, Volume 93
Serine incorporator 5 (SERINC5) is a recently identified restriction factor that strongly blocks HIV-1 entry but is counteracted by Nef. Notably, tier 1 HIV-1 Env proteins are sensitive to SERINC5, whereas the majority of tier 2/3 Env proteins are resistant to SERINC5, when viruses are produced from CD4-negative cells and tested by a single-round replication assay. Here, we investigated the Env-dependent SERINC5 antiviral mechanism by comparing tier 1 NL Env with tier 3 AD8 Env proteins. We f…
Michigan State UniversityMichigan State UniversityVeterinary Research InstituteVeterinary Research InstituteChinese Academy of Agricultural SciencesChinese Academy of Agricultural Sciences
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