7901
7901
8198
8198
9466
9466
12748
12748
14437
14437
16493
16493
18941
18941
20996
20996
23105
23105
6480
6480
2020
2011
University (269.2K)Research Institution (26K)Hospital (23.9K)Foundation (3K)Company (1.1K)Other (648)
1 - 10 of 269,295
Sort by
Publication
ID31875339Published Date2020-03-30JournalJournal of computational chemistry, 2020-03-30, Volume 41
The generalized Born with molecular volume and solvent accessible surface area (GBMV2/SA) implicit solvent model provides an accurate description of molecular volume and has the potential to accurately describe the conformational equilibria of structured and disordered proteins. However, its broader application has been limited by the computational cost and poor scaling in parallel computing. Here, we report an efficient implementation of both the electrostatic and nonpolar components of GBMV…
Xiping Gong Mara Chiricotto Xiaorong Liu Erik Nordquist Michael Feigshow 2 more
Publication
ID31891196Published Date2020-03-30JournalJournal of computational chemistry, 2020-03-30, Volume 41
Ab initio composite approaches have been utilized to model and predict main group thermochemistry within 1 kcal mol , on average, from well-established reliable experiments, primarily for molecules with less than 30 atoms. For molecules of increasing size and complexity, such as biomolecular complexes, composite methodologies have been limited in their application. Therefore, the domain-based local pair natural orbital (DLPNO) methods have been implemented within the correlation consistent co…
Publication
IDDOI:10.1177/1052562919890895Published Date2020-04-01JournalJournal of Management Education, 2020-04-01, Volume 44
Influence is a critical competency for success in the workplace. Past research has shown that two oral communication skills (listening and oral expression) are associated with interpersonal influence. This exploratory study examines the effectiveness of two pedagogies (leaderless group discussion [LGD] and oral presentation with a question and answer time [P+Q&A]) in developing these oral communication skills. MBA students enrolled in online courses participated in this pedagogical research. …
Robert D Costigan Kyle E Brink
Publication
ID31642070Published Date2020-04-01JournalThe Journal of comparative neurology, 2020-04-01, Volume 528
Neurons in the rostral ventrolateral medulla (RVLM) regulate blood pressure through direct projections to spinal sympathetic preganglionic neurons. Only some RVLM neurons are active under resting conditions due to significant, tonic inhibition by gamma-aminobutyric acid (GABA). Withdrawal of GABA receptor-mediated inhibition of the RVLM increases sympathetic outflow and blood pressure substantially, providing a mechanism by which the RVLM could contribute chronically to cardiovascular disease…
Patrick J Mueller Bozena E Fyk-Kolodziej Toni A Azar Ida J Llewellyn-Smith
Publication
ID31342166Published Date2020-04-01JournalSupportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer, 2020-04-01, Volume 28
We explored how lifetime comorbidities and treatment-related cancer symptoms were associated with quality of life (QOL) in rural cancer survivors.Survivors (n = 125) who were rural Illinois residents aged 18+ years old were recruited from January 2017 to September 2018. We conducted 4 multivariable regressions with QOL domains as outcomes (social well-being, functional well-being, mental health-MHQOL, physical health-PHQOL); the number of physical and psychological comorbidities (e.g., arthri…
Shaila M Strayhorn Leslie R Carnahan Kristine Zimmermann Theresa Hastert Karriem S Watsonshow 2 more
Health ResearchHealth ResearchUniversity of Illinois at ChicagoUniversity of Illinois at ChicagoUniversity of Illinois at Urbana-ChampaignUniversity of Illinois at Urbana-ChampaignWayne State UniversityWayne State University
Publication
ID32062146Published Date2020-04-01JournalBiomaterials, 2020-04-01, Volume 238
Fibroblasts are a critical component of tumor microenvironments and associate with cancer cells physically and biochemically during different stages of the disease. Existing cell culture models to study interactions between fibroblasts and cancer cells lack native tumor architecture or scalability. We developed a scalable organotypic model by robotically encapsulating a triple negative breast cancer (TNBC) cell spheroid within a natural extracellular matrix containing dispersed fibroblasts. W…
Sunil Singh Lucille A Ray Pradip Shahi Thakuri Sydnie Tran Michael Konopkashow 2 more
University of AkronUniversity of AkronUniversity of MichiganUniversity of Michigan
Publication
IDDOI:10.1530/eje-19-0905Published Date2020-04-01JournalEuropean Journal of Endocrinology, 2020-04-01, Volume 182
Context The human adrenal is the dominant source of androgens in castration-resistant prostate cancer (CRPC) and classic 21-hydroxylase deficiency (21OHD). Abiraterone, derived from the prodrug abiraterone acetate (AA), inhibits the activity of cytochrome P450 17-hydroxylase/17,20-lyase (CYP17A1), the enzyme required for all androgen biosynthesis. AA treatment effectively lowers testosterone and androstenedione in 21OHD and CRPC patients. The 11-oxygenated androgens are major adrenal-derived …
Cleveland ClinicCleveland ClinicUniversity of MichiganUniversity of Michigan
Publication
IDDOI:10.1093/rfs/hhz083Published Date2020-04-01JournalThe Review of Financial Studies, 2020-04-01, Volume 33
Abstract We consider the role of credit ratings when contracts between investors and portfolio managers are incomplete. In our model, a credit rating and a price on a risky bond both provide verifiable signals about a non-contractible state. We allow the investor to both impose ex ante restrictions on the manager’s action and provide outcome-based compensation. The optimal contract is a prohibitive one when the rating and price indicate a high likelihood of a low state, and relies on wages wh…
Christine A Parlour Uday Rajan
University of California SystemUniversity of California SystemUniversity of MichiganUniversity of Michigan
Publication
ID31027455Published Date2020-04-01JournalMedical care research and review : MCRR, 2020-04-01, Volume 77
Interest in high users of acute care continues to grow as health care organizations look to deliver cost-effective and high-quality care to patients. Since "super-utilizers" of acute care are responsible for disproportionately high health care spending, many programs and interventions have been implemented to reduce medical care use and costs in this population. This article presents a systematic review of the peer-reviewed and grey literature on evaluations of interventions to decrease preho…
Publication
ID31957540Published Date2020-04-01JournalRNA biology, 2020-04-01, Volume 17
RNA methylation, catalysed by a set of RNA methyltransferases (RNMTs), modulates RNA structures, properties, and biological functions. RNMTs are increasingly documented to be dysregulated in various human diseases, particularly developmental disorders and cancer. However, the genomic and transcriptomic alterations of RNMTs, as well as their functional roles in human cancer, are limited. In this study, we utilized an unbiased approach to examine copy number alterations and mutation rates of 58…
Top PeopleSee More
  • 423
  • 423
  • 423
  • 423
  • 423
  • 423
  • 423
  • 423
  • 423
  • 423
Top CompaniesSee More
  • 229
  • 157
  • 134
  • 54
  • 51
  • 49
  • 38
  • 36
  • 28
  • 19