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Patent
Publication NumberUS 20200158641Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2017-12-27Publication Date2020-05-21
Laser emission based microscope devices and methods of using such devices for detecting laser emissions from a tissue sample are provided. The scanning microscope has first and second reflection surfaces and a scanning cavity holding a stationary tissue sample with at least one fluorophore/lasing energy responsive species. At least a portion of the scanning cavity corresponds to a high quality factor (Q) Fabry-Pérot resonator cavity. A lasing pump source directs energy at the scanning cavity …
Patent
Publication NumberUS 20200160998Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-11-21Publication Date2020-05-21
A method of predicting patient deterioration includes receiving an electronic health record data set of the patient, determining a risk score corresponding to the patient by analyzing the electronic health record data set of the patient using a trained machine learning model, determining a threshold value using an online/reinforcement learning model, comparing the risk score to the threshold value, and when the risk score exceeds the threshold value, generating an alarm. A non-transitory comp…
Patent
Publication NumberUS 20200158931Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-11-20Publication Date2020-05-21
A colored visibly opaque, highly efficient NIR-transmitting optical filter displaying angle insensitivity is based on one-dimensional photonic crystals. The filter comprises a photonic crystal stack comprising at least one high refractive index layer and two low refractive index layers respectively disposed along a first side and a second side of the high refractive index layer. The photonic crystal stack may have 10 or fewer layers. The filter transmits a first portion of an electromagnetic …
Patent
Publication NumberUS 20200155501Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-06-26Publication Date2020-05-21
There is a continuing need for methods and compositions relating to hormone-receptor-dependent cancers, including pharmaceutical compositions including one or more compounds having activity against steroid hormone-receptor-dependent cancer and methods of treatment of a steroid hormone-receptor-dependent cancer in a subject using said pharmaceutical compositions. ELK1 Is a steroid hormone receptor tethering, protein that is implicated in hormone receptor dependent cancers. Compositions and met…
Patent
Publication NumberUS 20200155684Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-11-19Publication Date2020-05-21
Provided herein are compositions and method for improving drug solubility and delivery. In particular, provided herein are metal-organic frameworks and their use in improving drug solubility and delivery.
Patent
Publication NumberUS 20200157091Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-05-15Publication Date2020-05-21
The present disclosure provides compounds represented by Formula I and II: and the pharmaceutically acceptable salts and solvates thereof, wherein R1, R2, R3, X, W, Y, and Z are as defined as set forth in the specification. The present disclosure also provides compounds of Formula I and II for use to treat a condition or disorder responsive to LSD1 inhibition such as cancer.
Patent
Publication NumberUS 10653679Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-05-04Publication Date2020-05-19
The present disclosure provides, among other things, compositions and methods useful for inhibiting bacteria, such as Mycobacterium tuberculosis. These compositions and methods find many uses in medicine and research, e.g., treating subjects afflicted with active or latent bacterial infections. The compositions described herein are also useful for decontaminating surfaces (e.g., surgical tools or implants).
Patent
Publication NumberUS 10656062Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-01-17Publication Date2020-05-19
The disclosure relates to an irreversible dosimetric shock-detection substrate as well as related articles and methods. The shock-detection substrate incorporates a plurality of microcapsules serving as an irreversible means for detecting impact on the substrate. A shock above a characteristic threshold level experienced by the substrate induces an irreversible detectable change associated with the microcapsules upon shock-induced rupture. The irreversible detectable change provides a tamper-…
Patent
Publication NumberUS 10658560Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-05-24Publication Date2020-05-19
Thermoelectric materials based on tetrahedrite structures for thermoelectric devices and methods for producing thermoelectric materials and devices are disclosed.
Michigan State UniversityMichigan State UniversityUniversity of California SystemUniversity of California System
Patent
Publication NumberUS 10656117Filing StatusIssued PatentAvailabilityUnknownFiling Date2019-06-10Publication Date2020-05-19
Physical parameters of macromolecules are determined by measuring electrical current I over time for translocation events as the macromolecules in solution move between two liquid compartments that are separated by and fluidically coupled through a synthetic nanopore. Values of charge, volume, shape, rotational diffusion coefficient, and dipole moment are derived from the measurements.