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Patent
Publication NumberUS 10727372Filing StatusIssued PatentAvailabilityUnknownFiling Date2018-07-09Publication Date2020-07-28
A nanostructure optoelectronic device, in accordance with aspects of the present technology, can include a group-III element semiconductor with a first type of doping, one or more quantum structures including a dilute-Antimonide group-III-Nitride disposed on the first type of doped group-III element semiconductor, and a group-III element semiconductor with a second type of doping disposed on the dilute-Antimonide group-III-Nitride. The concentration of the Antimony (Sb) can be adjusted to var…
Patent
Publication NumberUS 10723718Filing StatusIssued PatentAvailabilityUnknownFiling Date2018-11-07Publication Date2020-07-28
This invention is in the field of medicinal chemistry. In particular, the invention relates to a new class of small-molecules having a triazole-methyl-piperidinyl-pyrolyl-propenone structure which function as modulators of shared epitope (SE)-calreticulin (CRT) binding and/or interaction, and their use as therapeutics for the treatment of immunoregulatory abnormalities (e.g., autoimmune diseases, inflammatory diseases (e.g., chronic inflammatory disease), and bone erosive diseases) by selecti…
Patent
Publication NumberUS 10724897Filing StatusIssued PatentAvailabilityUnknownFiling Date2016-06-16Publication Date2020-07-28
This disclosure describes a sensor for detecting vibrations, particularly low-frequency vibrations. The sensor is of a cascaded gapped cantilever construction and may include a single sensing beam extending from a base to a proof mass across the plurality of gaps, a mechanical beam opposite the piezoelectric beam. The sensor may be included in a system including a housing, a support, and electronic components for converting and measuring signal. The sensor may be mounted to an item of furnitu…
Wayne State UniversityWayne State UniversityNational Science FoundationNational Science Foundation
Patent
Publication NumberUS 10724930Filing StatusIssued PatentAvailabilityUnknownFiling Date2017-10-24Publication Date2020-07-28
Sandwich separation is based on forming a sandwich complex with a magnetic bead, buoyant bead, and a target. Once a sandwich formation is created, the sandwich can be separated using its dual physical properties, namely magnetism and buoyancy. Sandwich separation is highly specific, allows for removal of the beads that do not have any attached target, and reduces the number of background beads. Sandwich separation can also be used to allow for target detection in raw specimen. Also, improveme…
Patent
Publication NumberUS 20200232961Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-09-18Publication Date2020-07-23
The disclosure provides a synthetic polymer that mimics the passive absorption kinetics of the human intestinal tract. More particularly, disclosed is a silicone-based polymer, e.g., poly(dimethyl siloxane), poly(dimethyl silicone) and poly siloxane, that meets the requirements of a robust, semipermeable, and in vivo-relevant membrane for use in an in vitro method for measuring the absorption of a chemical compound, such as a therapeutic, e.g., a small-molecule or a biologic, that can be expe…
Patent
Publication NumberUS 20200230159Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2018-08-07Publication Date2020-07-23
An apoptosis-mimicking structure includes a polymeric core. The polymeric core includes a polymer backbone. The polymer backbone includes or is modified with a functional group to directly or indirectly bond to an eat me signaling molecule. An eat me signaling molecule is bonded directly or indirectly to the functional group. Other structures include a scaffold and the apoptosis-mimicking structure immobilized on or incorporated into the scaffold.
Patent
Publication NumberUS 20200234810Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2020-01-22Publication Date2020-07-23
Methods for identifying patients diagnosed with treatment resistant or refractory depression, pain or other clinical indications who are eligible to receive N-methyl-D-aspartate receptor antagonist, glycine receptor beta (GLRB) modulator, or α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptor (AMPAR)-based therapies to include determining the appropriate medication, an optimal dose for each patient, and determining which patients are not eligible to receive the therapy. The pharmaco…
Patent
Publication NumberUS 20200234795Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2020-01-22Publication Date2020-07-23
A method is presented for aligning a read with a haplotype. The method includes: constructing an overall matrix for computing alignment probabilities between a given read and a given haplotype, calculating, during a first pass, an alignment probability for each cell in the overall matrix using Pair-HMM method, where the alignment probabilities are calculated using fixed-point arithmetic; pruning cells from the overall matrix to derive a subset of unpruned cells; and calculating, during a seco…
Patent
Publication NumberUS 20200230603Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2020-01-17Publication Date2020-07-23
A microfluidic device system includes a channel having an entrance and an exit, a height at the entrance being greater than a height at the exit. The height of the channel may decrease continuously from the height at the entrance to the height at the exit. Cells or particles or beads traveling through the channel become trapped based on their size and/or deformability. A visual sensor captures images of the trapped cells or particles or beads, and image software analyzes the captured images t…
Patent
Publication NumberUS 20200235325Filing StatusPatent ApplicationAvailabilityUnknownFiling Date2019-12-20Publication Date2020-07-23
Organic photovoltaic cells (OPVs) and their compositions are described herein. In one or more embodiments, the OPV or solar cell includes a first electrode (e.g., cathode); a second electrode (e.g., anode); an active layer positioned between the first electrode and the second electrode; and a channel layer positioned between the first electrode and the active layer, wherein the channel layer is configured to laterally disperse a charge across the channel layer. In certain examples, the first …