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Opportunity
IDFBX2:3409Post Date2019-08-22
Chemical incorporation of a chiral center is important in a number of industrial applications including pharmaceuticals and material sciences. Incorporation of chiral centers often relies upon the utilization of chiral ligands that enable the absolute configuration of chiral center to be set. A number of privileged scaffolds, including chiral C2-symmetric ligands (BINOL and SPINOL), are frequently used for these transformations. However, the drawbacks of these privileged scaffold ligands o…
Opportunity
IDFBX2:3408Post Date2019-08-22
A hallmark of joint osteoarthritis (OA) is a progressive loss of cartilage that can cause painful joints or even mobility impairments if the loss becomes severe. MRI has the potential to detect early OA and thus will help scientists to develop an interventional strategy to protect or regenerate cartilage. However, conventional compositional MRI suffers from a well-known "magic angle effect (MAE)" in highly structured tissues such as cartilage tendon and potentially fibrous connective tissu…
Opportunity
IDFBX2:3403Post Date2019-08-22
Immobilization chemistry is in high demand for solid-state biosensor platforms. Even though various surface modification methods have been developed for subsequent immobilization chemistries, they often require a specific substrate material and are sensitive to fabrication conditions. Researchers at the University of Michigan have developed a mussel-inspired grafting method which can be used to attach various chemical functional groups to a wide variety of surface types. Possible s…
Opportunity
IDFBX2:3380Post Date2019-08-21
The Storm Intersection Forecast Tool ("SIFT") predicts the future position and time of samples of the ocean wind made by a new constellation of weather satellites and intersects them with the future position and time of active storms (hurricanes, typhoons, tropical cyclones). It also predicts when storm overpass measurements can be transmitted to the ground after they are made. SIFT is comprised of orbit propagators for the weather satellites, predictors for the time and locati…
Opportunity
IDFBX2:3398Post Date2019-08-21
Researchers at the University of Michigan have developed a suite of compounds and chemical syntheses for the production of 18F-radiolabeled cholesterols, which may be used for positron emission tomography (PET). The compounds are analogs of NP-59, an iodine-containing norcholesterol that has been used for SPECT imaging to detect functional endocrine abnormalities associated with adrenal pathologies, such as adrenal adenomas, aldosteronism, subclinical Cushing's syndrome, and ectop…
Opportunity
IDFBX2:3395Post Date2019-08-21
Polyvinylidene fluoride (PVDF) and its copolymers are electroactive materials but have required mechanical stretching post-processing to induce the ferroelectric beta-phase. The 300-400% elongation required limits the applications and processability of PVDF materials. Researchers at UM have developed a pre-processing method to increase beta-phase formation in PVDF without mechanical stretching. The modified PVDF displays unprecedented piezoelectric properties with a measured d33 c…
Opportunity
IDFBX2:3384Post Date2019-08-21
Young black men experience both physical and health challenges during the adulthood transitioning due to racial discrimination, poverty, violence and others. These stressors might result in chronic health issues, including depression, anxiety, social fears and substance abuse, which might further lead to difficulty in pursuing education, employment and relationships. Yet young black men tend to be reluctant to seek mental health support because of limited resources and traditional beliefs.…
Opportunity
IDFBX2:3393Post Date2019-08-21
Narrowband transmission filters for infrared wavelengths, particularly long wavelength infrared (LWIR), have been difficult to develop and implement. This has in turn limited the use of these longer wavelengths in technologies, such as hyperspectral imaging, remote sensing, and aerospace and aeronautics systems. Researchers at University of Michigan have developed a new approach to narrowband transmission filters that utilizes dielectric gratings (such as silicon/air gratings). …
Opportunity
IDFBX2:3397Post Date2019-08-21
Background 3D bioprinting is a tissue engineering technique that can produce biocompatible, complex three-dimensional structures from digital models, analogous to conventional 3D printing for plastic based materials. This is accomplished using materials collectively known as bioinks, which include broad classes of compounds like hydrogels or decellularized extracellular matrix proteins to create synthetic organ-like structures. A significant advantage of bioprinting over co…
Opportunity
IDFBX2:3396Post Date2019-08-21
Tourniquets help save lives by constricting blood flow to a traumatized limb thereby preventing excess blood loss in a medical emergency. Existing tourniquets are primarily designed for use by medical professionals and combat personnel and such as the military and law enforcement agencies. Application of these types of tourniquets can be painful and physically challenging, in part, due to a narrow width of the tourniquet band and a difficult to operate tightening apparatus. These design fl…