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Research Grant
Award Number1847847Funding AgencyNational Science FoundationEffective Date2019-04-01Expiration Date2024-03-31Funding Amount$192,441
NON-TECHNICAL DESCRIPTION: The discovery and development of new materials underlies technological revolutions in microelectronics. Recently, a new materials field has emerged that harnesses large chemical and structural disorder to its advantage. This project will use atomic-scale engineering of structural and chemical disorder to discover and understand these new materials to achieve unprecedented functionalities. This project aims to leverage state-of-the-art film deposition with in-situ st…
Research Grant
Award Number1846969Funding AgencyNational Science FoundationEffective Date2019-04-01Expiration Date2024-03-31Funding Amount$549,626
Advances in assistive devices that enable individuals with leg amputations to walk, e.g., robotic prosthesis, orthoses and exoskeletons, have been considerable in recent years. However, existing systems have trouble operating in dynamic, real-world environments that include unexpected disturbances. Thus, the goal of this CAREER project is to address the need for assistive robots that can naturally respond to disturbances by exploiting the underlying dynamics of human locomotion, i.e., by prov…
Research Grant
Award Number1845962Funding AgencyNational Science FoundationEffective Date2019-03-15Expiration Date2024-02-29Funding Amount$293,169
This proposal develops a computational framework that helps the domain scientists who employ advanced cyberinfrastructure ecosystem (e.g., for engineering, manufacturing, healthcare, etc.) to realistically and efficiently reconstruct, visualize, and analyze 3D and 4D (space-time) volumetric objects with complex geometric structures and highly anisotropic properties (such properties are characterized by the presence of specified orientations and aspect ratios in the system). For example, in me…
Research Grant
Award Number1851776Funding AgencyNational Science FoundationEffective Date2019-03-15Expiration Date2022-02-28Funding Amount$288,058
This Research Experiences for Undergraduates site award to Michigan State University, located in East Lansing, MI, supports the training of 8 students for 10 weeks. This program, funded by the Division of Chemistry in the Mathematical and Physical Science Directorate, engages participants in independent research in sustainable chemistry and chemical processes. This program trains participants to be stewards of the environment, leading toward safer laboratories and laboratory practices and red…
Research Grant
Award Number1851418Funding AgencyNational Science FoundationEffective Date2019-03-15Expiration Date2020-02-29Funding Amount$24,405
The fact that all life depends on water makes it one of the most vital substances on our planet, with populations across the world organizing ways to access the water they need to survive. At the same time, flood, drought, and contamination mark several ways that water can also pose a threat to life. Human activity -- such as mismanagement, travel, pollution, conflict, and widening social disparities -- can also contribute to water's potential danger, including the spread of deadly waterborne…
Research Grant
Project Number5R35HL135823-04Funding AgencyNational Institutes of HealthEffective Date2019-03-01Expiration Date2020-02-29Funding Amount$677,280
Abstract The overall vision is to create a detailed understanding of mechanisms that regulate the blood clotting system, with a goal of elucidating the aspects of the clotting machinery that function differentially in hemostasis versus thrombosis. The conceptual framework is that human thrombotic diseases result from an otherwise protective mechanism (immunothrombosis) gone awry. In this view, hemostasis following vascular injury is driven by the prompt exposure of blood to preexisting, natur…
Research Grant
Project Number5U54MD011227-04Funding AgencyNational Institutes of HealthEffective Date2019-03-01Expiration Date2020-02-29Funding Amount$371,127
This application develops a Transdisciplinary Collaborative Center (TCC) for Health Disparities Research on Chronic Disease Prevention within the DHHS-defined Region 5 titled The Flint Center for Health Equity Solutions (FCHES). Core Academic Faculty and their community partners bring significant research and practical expertise in health equity efforts, behavioral health interventions and epidemiology, geography and the effects of built environment on health, and physical fitness and healthy…
Research Grant
Project Number5R01CA204969-03Funding AgencyNational Institutes of HealthEffective Date2019-03-01Expiration Date2020-02-29Funding Amount$308,362
PROJECT SUMMARY: Pancreatic ductal adenocarcinoma (PDAC) is a disease of near uniform mortality, and with few tangible therapeutic modalities. Failure of traditional therapy is due to our limited understanding of how the tumor microenvironment (TME) can facilitate the rapid progression or recurrence of PDAC. Altered cellular metabolism is a hallmark of cancer cells, and much of the published literature has focused on neoplastic cell autonomous processes for these adaptations. Although cancer-…
Research Grant
Project Number1K23HL141539-01A1Funding AgencyNational Institutes of HealthEffective Date2019-03-01Expiration Date2020-02-29Funding Amount$191,886
PROJECT SUMMARY/ABSTRACT Margaret Salisbury, MD, MS is a Pulmonary and Critical Care physician at the University of Michigan. This K23 mentored career development application includes a coordinated 5-year plan of training and research activities designed to advance Dr. Salisbury toward her long-term goal of becoming an independent physician-scientist conducting patient-oriented research on fibrotic interstitial lung disease (ILD). ILD affects up to 1 in 14 American adults, with hypersensitivi…
Research Grant
Project Number1F31DE028740-01Funding AgencyNational Institutes of HealthEffective Date2019-03-01Expiration Date2020-02-29Funding Amount$37,315
PROJECT SUMMARY The incidence rates of head and neck squamous cell carcinoma (HNSCC) in the United States have quadrupled in the past several decades. The current standard treatment regimen is associated with significant co-morbidities such as dysphagia and osteoradionecrosis. The mechanisms underlying poor immunological host responses are multifactorial, and the most significant challenge is that HNSCC contains few tumor- specific cytotoxic T lymphocytes in the tumor microenvironment (TME), …