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Clinical Trial
Clinical Trial IDNCT04137107Start Date2020-04-01Completion Date2025-12-01PhasePhase 2/Phase 3Study TypeInterventionalStatusNot yet recruiting
This phase II/III trial studies the best dose of duloxetine and how well it works in preventing pain, tingling, and numbness (peripheral neuropathy) caused by treatment with oxaliplatin in patients with stage II-III colorectal cancer. Duloxetine increases the amount of certain chemicals in the brain that help relieve depression and pain. Giving duloxetine in patients undergoing treatment with oxaliplatin for colorectal cancer may help prevent peripheral neuropathy.
University of MichiganUniversity of MichiganNational Cancer Institute (NCI)National Cancer Institute (NCI)National Institutes of Health (NIH)National Institutes of Health (NIH)United States Department of Health and Human Services (HHS)United States Department of Health and Human Services (HHS)
Clinical Trial
Clinical Trial IDNCT04140162Start Date2020-04-01Completion Date2025-04-01PhasePhase 2Study TypeInterventionalStatusNot yet recruiting
This phase 2 trial will test whether the combination of DaraRd (daratumumab + lenalidomide + dexamethasone) as induction therapy, followed by DRVd (daratumumab + lenalidomide + bortezomib + dexamethasone) consolidation therapy, if needed, will result in more patients achieving minimal residual disease (MRD)-negative status, relative to the standard of care. Consolidation therapy will be administered only to those patients with MRD-positive status after induction therapy. This is a study based…
Clinical Trial
Clinical Trial IDNCT04036708Start Date2020-04-01Completion Date2022-01-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The proposed research will adapt the caregiver training and child neurodevelopmental assessment capacity that the PI previously built in Uganda beginning in 2008, to a community-based intervention model for the prevention of konzo in the Democratic Republic of Congo.
Clinical Trial
Clinical Trial IDNCT04008199Start Date2020-04-01Completion Date0031-06-29PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The investigators have developed, piloted, and propose to expand and to experimentally evaluate a speech-based service that connects expectant fathers to doctors and to each other over a simple phone call. This service, dubbed Super Abbu (Super Dad in English), addresses the challenges faced by existing efforts in several new and important ways: - The service targets fathers. Currently, the entire public health infrastructure in Punjab is geared towards providing information to women. - It su…
University of California DavisUniversity of California DavisUniversity of California SystemUniversity of California SystemUniversity of MichiganUniversity of MichiganInformation Technology UniversityInformation Technology UniversityUniversity of California, RiversideUniversity of California, Riverside
Clinical Trial
Clinical Trial IDNCT04225598Start Date2020-04-01Completion Date2022-08-01PhasePhase 2Study TypeInterventionalStatusNot yet recruiting
This study will (1) recruit, train and provide resources to approximately 30 Emergency Department (ED) sites throughout the U.S. using implementation facilitation strategies to provide ED-initiated buprenorphine (BUP) for patients presenting with opioid use disorder (OUD) who are not receiving medications for opioid use disorder (MOUD). Once implementation is adequately achieved, the sites will (2) conduct a randomized controlled trial (RCT) to compare the effectiveness of sublingual buprenor…
Gail Donofrio David A Fiellin Frank Lovecchio Andrew A Herring Erik S Andersonshow 15 more
Jackson Memorial HospitalJackson Memorial HospitalTampa General HospitalTampa General HospitalUniversity of ChicagoUniversity of ChicagoMaine Medical Center Research InstituteMaine Medical Center Research InstituteJohns Hopkins Applied Physics LabJohns Hopkins Applied Physics Labshow 15 more
Clinical Trial
Clinical Trial IDNCT04236596Start Date2020-04-01Completion Date2023-01-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
This study is to map the pudendal nerve. In this study the researchers will examine subjects who are already receiving an implanted stimulator at their pudendal nerve as part of their normal clinical care.
University of MichiganUniversity of MichiganNational Institutes of Health (NIH)National Institutes of Health (NIH)United States Department of Health and Human Services (HHS)United States Department of Health and Human Services (HHS)
Clinical Trial
Clinical Trial IDNCT04297735Start Date2020-03-01Completion Date2022-03-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The purpose of the study is to see if monthly telemedicine computer visits (visits using the computer) improve the time it takes to identify and treat an arrhythmia. The second purpose is to see if monthly telemedicine computer visits improves the participant's understanding of the arrhythmia and improves how the participant feels with daily activities.
Clinical Trial
Clinical Trial IDNCT03940716Start Date2020-03-01Completion Date0030-03-30PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
This study will use a randomized control trial design (RCT) to pilot test a multisession remote therapy behavioral intervention for risky firearm behaviors and associated behaviors/consequences among adolescents. The study will pilot a state-of-the-art intervention delivery approaches (e.g., remote therapy, smartphone-based APP intervention content delivery) for reducing violence and associated behaviors among urban youth. Given the significant morality and mortality associated with firearm v…
University of MichiganUniversity of MichiganNational Institute on Drug Abuse (NIDA)National Institute on Drug Abuse (NIDA)National Institutes of Health (NIH)National Institutes of Health (NIH)United States Department of Health and Human Services (HHS)United States Department of Health and Human Services (HHS)
Clinical Trial
Clinical Trial IDNCT03964974Start Date2020-03-01Completion Date2021-12-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
As medical cannabis use becomes more common in the United States, it is essential to understand the ways in which adults who use medical cannabis perceive the benefits of cannabis use and to identify effective strategies to help them cope with these problems. Emerging data indicate that insomnia and/or use of cannabis for sleep are very common in medical cannabis patients. The present study will adapt and gather pilot data on the impact of a Cognitive Behavioral Therapy for insomnia (CBTi-CB)…
University of MichiganUniversity of MichiganNational Institute on Drug Abuse (NIDA)National Institute on Drug Abuse (NIDA)National Institutes of Health (NIH)National Institutes of Health (NIH)United States Department of Health and Human Services (HHS)United States Department of Health and Human Services (HHS)
Clinical Trial
Clinical Trial IDNCT04008121Start Date2020-03-01Completion Date2020-12-01PhaseEarly Phase 1Study TypeInterventionalStatusNot yet recruiting
The objective of this study is to evaluate the safety and image quality of the investigational dye, MB-102, compared to the control dye (fluorescein sodium) in healthy and diseased eyes using fluorescent angiography for retinal vascular disease diagnosis and monitoring.
Richard B Dorshow Yannis M Paulus
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