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Clinical Trial
Clinical Trial IDNCT03381183Start Date2019-06-01Completion Date2021-06-01PhasePhase 1/Phase 2Study TypeInterventionalStatusNot yet recruiting
The purpose of this study is to see if the IRX-2 regimen, durvalumab, and tremelimumab will have a tolerable safety profile and will increase the intratumoral immune profile compared with the pretreatment tumors.
Christine H Chung Nabil F Saba
H. Lee Moffitt Cancer Center and Research InstituteH. Lee Moffitt Cancer Center and Research InstituteEmory UniversityEmory UniversityUniversity of MichiganUniversity of Michigan
Clinical Trial
Clinical Trial IDNCT03785873Start Date2019-06-01Completion Date2023-05-01PhasePhase 1/Phase 2Study TypeInterventionalStatusNot yet recruiting
The purpose of this study is to test the effectiveness (how well the drug works), safety, and tolerability of the investigational drug combination of nivolumab plus nal-irinotecan, 5-fluorouracil, and leucovorin for patients with advanced or metastatic biliary tract cancer after progression on first-line systemic therapy.
University of MichiganUniversity of MichiganIpsenIpsenBristol-Myers SquibbBristol-Myers Squibb
Clinical Trial
Clinical Trial IDNCT03452267Start Date2019-06-01Completion Date2020-06-01PhasePhase 2/Phase 3Study TypeInterventionalStatusNot yet recruiting
The insulin sensitizing effects of metformin and pioglitazone in the skeletal muscle remain unknown. Our group aims to analyze molecular changes within the skeletal muscle of pre-diabetic patients through the use of a clinical trial in humans.
Clinical Trial
Clinical Trial IDNCT03735979Start Date2019-06-01Completion Date2023-04-01PhasePhase 3Study TypeInterventionalStatusNot yet recruiting
The primary efficacy objective of the MOST trial is to determine if argatroban (100µg/kg bolus followed by 3µg/kg per minute for 12 hours) or eptifibatide (135µg/kg bolus followed by 0.75µg/kg/min infusion for two hours) results in improved 90-day modified Rankin scores (mRS) as compared with placebo in acute ischemic stroke (AIS) patients treated with 0.9mg/kg IV rt-PA within three hours of symptom onset. Patients may also receive endovascular thrombectomy (ET) per usual care. Time of onset …
Opeolu M Adeoye
St. Joseph's Hospital and Medical CenterSt. Joseph's Hospital and Medical CenterStanford UniversityStanford UniversitySwedish Medical CenterSwedish Medical CenterYale-New Haven HospitalYale-New Haven HospitalYale UniversityYale Universityshow 15 more
Clinical Trial
Clinical Trial IDNCT03842696Start Date2019-06-01Completion Date2023-08-01PhasePhase 1/Phase 2Study TypeInterventionalStatusNot yet recruiting
The purpose of this study is to determine the recommended phase 2 dose of the drug Vorinostat in children, adolescents and young adults following allogeneic HCT and determine whether the addition of Vorinostat to the standard preventive therapy (tacrolimus / methotrexate) will reduce the incidence of graft versus host disease (GVHD) following unrelated donor, myeloablative transplant in children, adolescents and young adults.
Clinical Trial
Clinical Trial IDNCT03878914Start Date2019-05-01Completion Date2021-04-01PhasePhase 4Study TypeInterventionalStatusNot yet recruiting
Idiopathic nephrotic syndrome (INS) is one of the most common glomerular pathologies in children and corticosteroid therapy is its most effective treatment. The total duration of treatment ranges anywhere from two to six months, generally about 3 months. The main objective of our study is to test the feasibility of a shorter total duration (two months) of corticosteroid therapy in patients who show a quicker treatment response to the initial treatment.
Tej K Mattoo Hong Xuphd Ahmed El-Refaey Amarjeet Mehta Rachita Dhullshow 1 more
Children's Hospital of MichiganChildren's Hospital of MichiganFudan UniversityFudan UniversityWayne State UniversityWayne State UniversitySawai ManSingh Medical CollegeSawai ManSingh Medical College
Clinical Trial
Clinical Trial IDNCT03883165Start Date2019-05-01Completion Date2023-02-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
Sport-related concussion is a common and serious injury that can affect athletes of all ages in any sport. The purpose of this project is to study the effect of a 12-week manual resistance neck strengthening exercise program on participants' neck size and strength and how their heads and necks move during simulated sport-associated tasks. This study will help determine if greater neck strength may lower an athlete's risk of sport-related concussion. Each healthy male and female soccer athlete…
University of MichiganUniversity of MichiganNational Institute of Child Health and Human Development (NICHD)National Institute of Child Health and Human Development (NICHD)National Institutes of Health (NIH)National Institutes of Health (NIH)United States Department of Health and Human Services (HHS)United States Department of Health and Human Services (HHS)
Clinical Trial
Clinical Trial IDNCT03874845Start Date2019-05-01Completion Date2022-03-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
This study will examine the effects of psychotherapy as treatment for PTSD. This research will see how brain activity and brain connectivity is affected by Mindfulness Based Cognitive Therapy (MBCT) and Muscle Relaxation Therapy (MRT). Participants that qualify to be in this study will receive 8 weeks of group therapy in MBCT or MRT. Prior to receiving therapy participants will: complete baseline assessments related to their PTSD; fill out surveys; have an functional magnetic resonance imagin…
University of MichiganUniversity of MichiganNational Institute of Mental Health (NIMH)National Institute of Mental Health (NIMH)National Institutes of Health (NIH)National Institutes of Health (NIH)United States Department of Health and Human Services (HHS)United States Department of Health and Human Services (HHS)
Clinical Trial
Clinical Trial IDNCT03632317Start Date2019-05-01Completion Date2025-09-01PhasePhase 2Study TypeInterventionalStatusRecruiting
This phase 2 trial will evaluate the activity of Panobinostat in combination with Everolimus for children with gliomas harboring H3.1 or H3.3K27M mutation, including newly diagnosed high-grade glioma or DIPG (diffuse intrinsic pontine glioma) after radiation (stratum A) and recurrent/progressive glioma (grade II-IV, including DIPG) (stratum B).
Clinical Trial
Clinical Trial IDNCT03812653Start Date2019-05-01Completion Date2023-11-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The purpose of this study is to determine whether treatment of obstructive sleep apnea (OSA) with positive airway pressure starting shortly after acute ischemic stroke or high risk TIA (1) reduces recurrent stroke, acute coronary syndrome, and all-cause mortality 6 months after the event, and (2) improves stroke outcomes at 3 months in patients who experienced an ischemic stroke.
Devin L Brown Ronald Chervin Soo Young Kwon Joni Clark Chelsea Kidwellshow 15 more
University of AlabamaUniversity of AlabamaCedars-Sinai Medical CenterCedars-Sinai Medical CenterUniversity of California Los Angeles (UCLA)University of California Los Angeles (UCLA)University of California SystemUniversity of California SystemHuntington Memorial HospitalHuntington Memorial Hospitalshow 15 more
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