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Clinical Trial
Clinical Trial IDNCT03787680Start Date2019-10-01Completion Date2025-11-01PhasePhase 2Study TypeInterventionalStatusNot yet recruiting
The purpose of this study is to test the effectiveness (how well the drugs work), safety, and tolerability of the investigational drug combination of olaparib and AZD6738 for all patients with metastatic castration-resistant prostate cancer.
Clinical Trial
Clinical Trial IDNCT04040322Start Date2019-10-01Completion Date2020-06-01PhasePhase 3Study TypeInterventionalStatusNot yet recruiting
This is a Phase 3, multicenter, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of iloprost on the frequency of and relief from symptomatic digital ischemic episodes in subjects with systemic sclerosis.
Wade Benton
Stanford UniversityStanford UniversityUniversity of California San Francisco (UCSF)University of California San Francisco (UCSF)University of California SystemUniversity of California SystemJohns Hopkins UniversityJohns Hopkins UniversityUniversity of MichiganUniversity of Michiganshow 6 more
Clinical Trial
Clinical Trial IDNCT03883165Start Date2019-10-01Completion Date2023-02-01PhaseN/AStudy TypeInterventionalStatusRecruiting
Sport-related concussion is a common and serious injury that can affect athletes of all ages in any sport. The purpose of this project is to study the effect of a 12-week manual resistance neck strengthening exercise program on participants' neck size and strength and how their heads and necks move during simulated sport-associated tasks. This study will help determine if greater neck strength may lower an athlete's risk of sport-related concussion. Each healthy male and female soccer athlete…
University of MichiganUniversity of MichiganNational Institute of Child Health and Human Development (NICHD)National Institute of Child Health and Human Development (NICHD)National Institutes of Health (NIH)National Institutes of Health (NIH)United States Department of Health and Human Services (HHS)United States Department of Health and Human Services (HHS)
Clinical Trial
Clinical Trial IDNCT03889600Start Date2019-10-01Completion Date2021-03-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
Over 27 million Americans are diagnosed with Type 2 Diabetes Mellitus (T2DM), and their health outcomes, including hospitalization, emergency department use, and hospital readmission, are largely driven by social determinants; diabetes complications are largely attributable to unmet health-related social needs. Investigators will conduct a pilot feasibility trial of the Re-Engineered Discharge for Diabetes-Computer Adaptive Testing (REDD-CAT) system to inform the design of a future, fully-pow…
Suzanne E Mitchell
Boston Medical CenterBoston Medical CenterBoston UniversityBoston UniversityUniversity of MichiganUniversity of Michigan
Clinical Trial
Clinical Trial IDNCT04066348Start Date2019-10-01Completion Date2023-09-01PhasePhase 2Study TypeInterventionalStatusNot yet recruiting
This study evaluates the therapeutic effects of Etanercept (Enbrel) on the treatment of blast/noise induced tinnitus in adults. Half of the participants will receive 2 x 25mg/ Entanercept injections, and the other half will receive placebo injections.
Jin-Sheng Zhang Shaowen Bao Faydyeh Barakat Michael E Hoffer Fatima Husainshow 7 more
University of MiamiUniversity of MiamiUniversity of Illinois at Urbana-ChampaignUniversity of Illinois at Urbana-ChampaignUniversity of IowaUniversity of IowaWayne State UniversityWayne State UniversityMichigan Ear InstituteMichigan Ear Instituteshow 3 more
Clinical Trial
Clinical Trial IDNCT03632317Start Date2019-10-01Completion Date2025-10-01PhasePhase 2Study TypeInterventionalStatusWithdrawn
This phase 2 trial will evaluate the activity of Panobinostat in combination with Everolimus for children with gliomas harboring H3.1 or H3.3K27M mutation, including newly diagnosed high-grade glioma or DIPG (diffuse intrinsic pontine glioma) after radiation (stratum A) and recurrent/progressive glioma (grade II-IV, including DIPG) (stratum B).
Clinical Trial
Clinical Trial IDNCT04010019Start Date2019-10-01Completion Date2020-06-01PhaseN/AStudy TypeInterventionalStatusRecruiting
This randomized trial will create and compare two private Facebook conditions for patients with chronic pain. The control condition will be comprised of groups of patients who communicate without much clinician / moderator input, and the experimental condition will have a clinician moderating and teaching patients several techniques designed to facilitate social disclosure, validation, and emotional engagement with avoided activities.
Clinical Trial
Clinical Trial IDNCT04052828Start Date2019-10-01Completion Date2024-01-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
This is a single site pilot trial to assess the feasibility and safety of treating severe CDH with Fetal Endoscopic Tracheal Occlusion with the Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter (BALTACCI-BDPE100) at Michigan Medicine. The study will enroll pregnant women that meet study criteria. Participants will have placement of FETO between gestational age at 27 weeks plus 0 days and 29 weeks 6 days. The timing for removal of FETO will ideally be between 34 w…
Clinical Trial
Clinical Trial IDNCT04035928Start Date2019-10-01Completion Date2023-07-01PhaseN/AStudy TypeInterventionalStatusRecruiting
This study will use a 3D scanner to print a 3D model or mold for each patient's prosthesis. The goal of this study to provide patients with a new, faster method of imaging and creating prostheses that preserves the quality of the current method while reducing time spent by both the patient and providers. Patients that are eligible will have a non-invasive 3D scanner (Artec Space Spider) to image the indicated areas of their head and face to help create their new prosthesis. Patients will come…
Clinical Trial
Clinical Trial IDNCT03960827Start Date2019-10-01Completion Date2023-09-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The goal of the Molecular Transducers of Physical Activity Consortium (MoTrPAC) is to assess molecular changes that occur in response to physical activity (PA). To achieve this aim, a mechanistic randomized controlled trial (RCT) is conducted, in which adult study participants are randomized to endurance exercise (EE) training, resistance exercise (RE) training, or no exercise Control for a period of approximately 12 weeks. The overarching hypothesis is that there are discoverable molecular t…
Marco Pahor
University of Alabama BirminghamUniversity of Alabama BirminghamUniversity of ColoradoUniversity of ColoradoBall State UniversityBall State UniversityPennington Biomedical Research CenterPennington Biomedical Research CenterDuke UniversityDuke Universityshow 15 more
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