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Clinical Trial
Clinical Trial IDNCT03883165Start Date2019-12-01Completion Date2023-02-01PhaseN/AStudy TypeInterventionalStatusRecruiting
Sport-related concussion is a common and serious injury that can affect athletes of all ages in any sport. The purpose of this project is to study the effect of a 12-week manual resistance neck strengthening exercise program on participants' neck size and strength and how their heads and necks move during simulated sport-associated tasks. This study will help determine if greater neck strength may lower an athlete's risk of sport-related concussion. Each healthy male and female soccer athlete…
University of MichiganUniversity of MichiganNational Institute of Child Health and Human Development (NICHD)National Institute of Child Health and Human Development (NICHD)National Institutes of Health (NIH)National Institutes of Health (NIH)United States Department of Health and Human Services (HHS)United States Department of Health and Human Services (HHS)
Clinical Trial
Clinical Trial IDNCT03722381Start Date2019-12-01Completion Date0029-12-30Study TypeObservationalStatusNot yet recruiting
The current study will evaluate the plasma pharmacokinetics of amlodipine in a cohort of 8 adult volunteers who are receiving regular hemodialysis treatment (HD) 3 days a week for 4 hours each day and have been taking a total daily dose of 5-10 mg of amlodipine besylate for >30 days as part of their usual care. Blood sampling will occur over 13 hours, with frequent sampling during HD and in the 4 hours after termination of HD treatment. The 8 subjects will all receive their prescribed total d…
Clinical Trial
Clinical Trial IDNCT04069312Start Date2019-12-01Completion Date2023-02-01PhasePhase 3Study TypeInterventionalStatusNot yet recruiting
A multi-center, randomized, 36-month, parallel- group, non-inferiority, phase III study to compare the effectiveness of roflumilast (Daliresp, 500 mcg quaque die (QD) or alternate regimen) therapy versus azithromycin (250 mg QD, 500 mg QD three times per week, or alternate regimen) to prevent hospitalization or death in a patients at high risk for COPD exacerbations.
Jerry Krishnan Robert A Wise Surya Bhatt Mark Avdalovic Michael Hanleyshow 15 more
University of AlabamaUniversity of AlabamaUniversity of ArizonaUniversity of ArizonaDenver HealthDenver HealthThe NorthwesternThe NorthwesternJesse Brown VA Medical CenterJesse Brown VA Medical Centershow 15 more
Clinical Trial
Clinical Trial IDNCT03836482Start Date2019-12-01Completion Date2021-02-01PhaseN/AStudy TypeInterventionalStatusRecruiting
The purpose of this study is to evaluate the selective cytopheretic device on the immune dysregulated state of congestive heart failure(CHF) with CRS and to assess the benefit of the device to improve cardiovascular and renal function. The study will enroll eligible patients in the ICU with acute on chronic systolic heart failure and worsening renal function due to cardiorenal syndrome while awaiting LVAD implantation. In this study patients who are eligible and agree to participate will rece…
Clinical Trial
Clinical Trial IDNCT04140162Start Date2019-12-01Completion Date2024-12-01PhasePhase 2Study TypeInterventionalStatusNot yet recruiting
This phase 2 trial will test whether the combination of DaraRd (daratumumab + lenalidomide + dexamethasone) as induction therapy, followed by DRVd (daratumumab + lenalidomide + bortezomib + dexamethasone) consolidation therapy, if needed, will result in more patients achieving minimal residual disease (MRD)-negative status, relative to the standard of care. Consolidation therapy will be administered only to those patients with MRD-positive status after induction therapy. This is a study based…
Clinical Trial
Clinical Trial IDNCT04004416Start Date2019-12-01Completion Date2024-09-01PhasePhase 4Study TypeInterventionalStatusNot yet recruiting
The purpose of this study is to better understand mental illness and will test the hypotheses that while viewing affective stimuli, patient groups will show increased blood oxygenation level dependent (BOLD) signal by fMRI after lorazepam. This study will enroll participants between the ages of 16 and 60, who have a psychotic illness (such as schizophrenia, bipolar disorder, and schizoaffective disorder. The study will also enroll eligible participants without any psychiatric illness, to comp…
University of MichiganUniversity of MichiganNational Institute of Mental Health (NIMH)National Institute of Mental Health (NIMH)National Institutes of Health (NIH)National Institutes of Health (NIH)United States Department of Health and Human Services (HHS)United States Department of Health and Human Services (HHS)
Clinical Trial
Clinical Trial IDNCT04139434Start Date2019-12-01Completion Date2022-12-01PhasePhase 1Study TypeInterventionalStatusNot yet recruiting
A Phase 1, Multi-center, Open-label, Dose Escalation Study to Evaluate Safety, Tolerability, Pharmacokinetics, and Clinical Activity of Orally Administered LP-108 in Subjects with Relapsed or Refractory Myelodysplastic Syndromes (MDS), Chronic Myelomonocytic Leukemia (CMML), or Acute Myeloid Leukemia (AML)
Naval G Daver Marina Konopleva
H. Lee Moffitt Cancer Center and Research InstituteH. Lee Moffitt Cancer Center and Research InstituteUniversity of MichiganUniversity of MichiganUniversity of Texas MD Anderson Cancer CenterUniversity of Texas MD Anderson Cancer CenterUniversity of Texas SystemUniversity of Texas System
Clinical Trial
Clinical Trial IDNCT03978936Start Date2019-12-01Completion Date0001-06-29PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
Improving Medication Adherence with Telehealthcare Medication Therapy Management to Change Health Outcomes in Adolescents and Young Adults with Asthma (MATCH) is a multi-center, randomized parallel group study targeted to an at-risk population of Adolescents and Young Adults (AYA) with uncontrolled asthma who have poor adherence with prescribed Inhaled corticosteroid (ICS) therapy.
Kathryn V Blake Robert A Wise Janet Holbrook
University of Alabama BirminghamUniversity of Alabama BirminghamUniversity of ArizonaUniversity of ArizonaUniversity of California San Francisco (UCSF)University of California San Francisco (UCSF)University of California SystemUniversity of California SystemNational Jewish HealthNational Jewish Healthshow 15 more
Clinical Trial
Clinical Trial IDNCT04052828Start Date2019-12-01Completion Date2024-01-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
This is a single site pilot trial to assess the feasibility and safety of treating severe CDH with Fetal Endoscopic Tracheal Occlusion with the Goldballoon Detachable Balloon (GOLDBAL2) along with the Delivery Microcatheter (BALTACCI-BDPE100) at Michigan Medicine. The study will enroll pregnant women that meet study criteria. Participants will have placement of FETO between gestational age at 27 weeks plus 0 days and 29 weeks 6 days. The timing for removal of FETO will ideally be between 34 w…
Clinical Trial
Clinical Trial IDNCT04010461Start Date2019-12-01Completion Date2021-09-01PhaseN/AStudy TypeInterventionalStatusNot yet recruiting
The purpose of this study is to improve understanding of the way transcranial magnetic stimulation (TMS), a form of non-invasive brain stimulation, affects the brain. The study hypothesis that when theta burst stimulation (TBS) is applied during a controlled mental state, network changes will be facilitated, compared to stimulation when mental state is uncontrolled. This study will focus on the dorsolateral prefrontal cortex (dlPFC) and the associated frontoparietal network (FPN), which subse…
University of MichiganUniversity of MichiganNational Institute of Mental Health (NIMH)National Institute of Mental Health (NIMH)National Institutes of Health (NIH)National Institutes of Health (NIH)United States Department of Health and Human Services (HHS)United States Department of Health and Human Services (HHS)
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