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University (369.2K)Research Institution (29.3K)Hospital (27.7K)Company (7K)Foundation (3.9K)Other (746)Investor (250)
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Publication
ID32050392Published Date2020-04-10JournalThe Science of the total environment, 2020-04-10, Volume 712
Polychlorinated dibenzo-p-dioxins and dibenzofurans are a group of chemically-related pollutants categorically known as dioxins. Some of their chlorinated congeners are among the most hazardous pollutants that persist in the environment. This persistence is due in part to the limited number of bacteria capable of metabolizing these compounds, but also to their limited bioavailability in soil. We used Sphingomonas wittichii strain RW1 (RW1), one of the few strains able to grow on dioxin, to ch…
Michigan State UniversityMichigan State UniversityRutgers UniversityRutgers UniversityPurdue UniversityPurdue University
Publication
ID32035620Published Date2020-04-09JournalBiochemical and biophysical research communications, 2020-04-09, Volume 524
Post-translational modifications (PTMs) play pivotal roles in controlling the stability and activity of the tumor suppressor p53 in response to distinct stressors. Here we report an unexpected finding of a short chain fatty acid modification of p53 in human cells. Crotonic acid (CA) treatment induces p53 crotonylation, but surprisingly reduces its protein, but not mRNA level, leading to inhibition of p53 activity in a dose dependent fashion. Surprisingly this crotonylation targets serine 46, …
Peng Liao Nimisha Bhattarai Bo Cao Xiang Zhou Ji Hoon Jungshow 7 more
Tulane UniversityTulane UniversityUniversity of MichiganUniversity of MichiganFudan UniversityFudan UniversityGeorgia State UniversityGeorgia State University
Publication
ID31972284Published Date2020-04-15JournalNeuroImage, 2020-04-15, Volume 210
Non-heme iron accumulation contributes to age-related decline in brain structure and cognition via a cascade of oxidative stress and inflammation, although its effect on brain function is largely unexplored. Thus, we examine the impact of striatal iron on dynamic range of BOLD modulation to working memory load. N ​= ​166 healthy adults (age 20-94) underwent cognitive testing and an imaging session including n-back (0-, 2-, 3-, and 4-back fMRI), R2*-weighted imaging, and pcASL to measure cereb…
Karen M Rodrigue A M Daugherty Chris M Foster Kristen M Kennedy
The University of DallasThe University of DallasUniversity of Texas SystemUniversity of Texas SystemWayne State UniversityWayne State University
Publication
ID32070676Published Date2020-04-15JournalJournal of neuroscience methods, 2020-04-15, Volume 336
Stereology and histomorphometry are widely used by investigators to quantify nerve characteristics in normal and pathological states, including nerve injury and regeneration. While these methods of analysis are complementary, no study to date has systematically compared both approaches in peripheral nerve. This study investigated the reliability of design-based stereology versus semi-automated binary imaging histomorphometry for assessing healthy peripheral nerve characteristics.Stereological…
Daniel A Hunter Deng Pan Matthew D Wood Alison K Snyder-Warwick Amy M Mooreshow 3 more
Washington University School Of MedicineWashington University School Of MedicineOhio State UniversityOhio State UniversityUniversity of MichiganUniversity of Michigan
Publication
ID31991179Published Date2020-04-06JournalBehavioural brain research, 2020-04-06, Volume 383
Attentional bias is linked to a range of mood disorders, including posttraumatic stress disorder (PTSD). The present study examined attention bias patterns in African American children exposed to trauma, in order to better understand potential risk factors for PTSD.31 children (ages 8-14) completed an eye-tracking task to assess gaze bias patterns while viewing pairs of emotional and neutral faces. Trauma exposure and PTSD symptoms were assessed in a subsample of children (n = 24).Repeated me…
Maya Lakshman Lauren Murphy Yara Mekawi Sierra Carter Maria Briscioneshow 5 more
Emory UniversityEmory UniversityGeorgia State UniversityGeorgia State UniversityU.S. Department of Veterans AffairsU.S. Department of Veterans AffairsWayne State UniversityWayne State University
Publication
ID31978400Published Date2020-04-15JournalArchives of biochemistry and biophysics, 2020-04-15, Volume 683
A Pseudomonas CoA ligase (BadA) biocatalyzed aroyl CoA thioesters used by a downstream N-benzoyltransferase (NDTNBT) in a cascade reaction made aroyl analogs of the anticancer drug paclitaxel. BadA kept the high-cost aroyl CoA substrates at saturation for the downstream NDTNBT by recycling CoA when it was added as the limiting reactant. A deacylated taxane substrate N-debenzoyl-2'-deoxypaclitaxel was converted to its benzoylated product at a higher yield, compared to the converted yield in as…
Sean A Sullivan Irosha N Nawarathne Kevin D Walker
Publication
ID31925971Published Date2020-04-15JournalStatistics in medicine, 2020-04-15, Volume 39
We develop methodology that allows peer effects (also referred to as social influence and contagion) to be modified by the structural importance of the focal actor's position in the network. The methodology is first developed for a single peer effect and then extended to simultaneously model multiple peer-effects and their modifications by the structural importance of the focal actor. This work is motivated by the diffusion of implantable cardioverter defibrillators (ICDs) in patients with co…
A James Omalley Erika L Moen Julie P W Bynum Andrea M Austin Jonathan S Skinner
Geisel School of Medicine at DartmouthGeisel School of Medicine at DartmouthUniversity of MichiganUniversity of Michigan
Publication
ID32090805Published Date2020-04-15JournalJournal of environmental management, 2020-04-15, Volume 260
When confronted with concerns or backlash as a result of their environmental or sustainability performance, companies may elect to address them head-on by directly correcting their real or perceived misdeeds. However, it is often the case that businesses are unwilling or unable to address their transgressions directly; in these cases, they may elect to draw attention to indirect substantiality benefits unfolding in areas unrelated to where the concerns or backlash initially arose. In this stu…
Sara Goto Gray Bernadette Sutterlin Michael Siegrist Joseph Arvai
University of MichiganUniversity of MichiganDecision ResearchDecision Research
Publication
ID32090834Published Date2020-04-15JournalJournal of environmental management, 2020-04-15, Volume 260
While planning and management of urban green space (UGS) remain primarily driven by policymakers and expert knowledge, increasing attention has been paid to the general public's perception of and demand for UGS. This study was conducted to provide price-related outcomes to support UGS-related decision making and achieve an improved understanding of the causal relationships underpinning the residents' willingness-to-pay (WTP) for UGS conservation. An extensive survey with 3000 urban residents …
Yuqing Tian Hongjuan Wu Guangshi Zhang Luocen Wang Duo Zhengshow 1 more
Huazhong University of Science and TechnologyHuazhong University of Science and TechnologyUniversity of MichiganUniversity of MichiganUniversity of OxfordUniversity of Oxford
Publication
ID31958582Published Date2020-04-15JournalNeuroImage, 2020-04-15, Volume 210
Lower- and higher-order visual cortices in the posterior brain, ranging from the medial- and lateral-occipital to fusiform regions, are suggested to support visual object recognition, whereas the frontal eye field (FEF) plays a role in saccadic eye movements which optimize visual processing. Previous studies using electrophysiology and functional MRI techniques have reported that tasks requiring visual object recognition elicited cortical activation sequentially in the aforementioned posterio…
Children's Hospital of MichiganChildren's Hospital of MichiganWayne State UniversityWayne State UniversityWakayama Medical UniversityWakayama Medical University
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