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University (277.9K)Research Institution (19.8K)Hospital (18.5K)Company (6.7K)Foundation (2.8K)Other (2.4K)Investor (188)
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Publication
ID31331642Published Date2019-09-17JournalBiochemical and biophysical research communications, 2019-09-17, Volume 517
Interleukin-6 (IL-6) has become a target of interest for drug development aiming to treat diabetic retinopathy. Since IL-6 signaling can promote beneficial as well as detrimental effects via two different signaling pathways, the objective of the present study was to investigate the effects of classical IL-6 and IL-6 trans-signaling on human Müller cells (HMC), which are important for the development of diabetic retinopathy. HMCs were cultured in normal (5 mmol/L) and high (25 mmol/L) glucose …
Publication
ID31352879Published Date2019-09-16JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019-09-16, Volume 374
Mammalian carnivores are declining worldwide owing to human activities. Behavioural indicators have the potential to help identify population trends and inform conservation actions, although this area of research is understudied. We investigate whether behaviour is linked to abundance in a community of carnivores in the Masai Mara National Reserve, Kenya. Anthropogenic disturbance increased exponentially in parts of the Reserve between 1988 and 2017, mainly owing to daily incursions by large …
Publication
ID31146063Published Date2019-09-15JournalThe Science of the total environment, 2019-09-15, Volume 683
Efforts to study how human activities have influenced the environment since the end of the Roman period to present day are lacking for North Central Europe. Here, we present new lead (Pb) isotope data determined from two sediment cores collected from ancient lakes spanning the last 1500 years, located in the Kuyavian-Pomeranian Voivodeship, Poland. Study sites at Radzyń Chełmiński and Rywałd were used to differentiate Pb sources. Radzyń Chełmiński is located in the vicinity of a late Medieval…
Heidi B Babos Stuart Black Aleks Pluskowski Alex Brown Megan Rohrssenshow 1 more
University of ReadingUniversity of ReadingCentral Michigan UniversityCentral Michigan University
Research Grant
Award Number1931738Funding AgencyNational Science FoundationEffective Date2019-09-15Expiration Date2022-08-31Funding Amount$400,000
Complex cyber-physical systems (CPS) that operate in dynamic and uncertain environments will inevitably encounter unanticipated situations during their operation. Examples range from naturally occurring faults in both the cyber and physical components to attacks launched by malicious entities with the purpose of disrupting normal operations. As infrastructures, e.g. energy, transportation, industrial systems and built environments, are getting smarter, the chance of a fault or attack increase…
Publication
ID31181446Published Date2019-09-15JournalWater research, 2019-09-15, Volume 161
Sequestration of anthropogenic antibiotics by biochars from waters may be a promising strategy to minimize environmental and human health risks of antibiotic resistance. This study investigated the long-term sequestration of lincomycin by 17 slow-pyrolysis biochars using batch sorption experiments during 365 days. Sorption kinetics were well fitted to the Weber-Morris intraparticle diffusion model for all tested biochars with the intraparticle diffusion rate constant (k) of 25.3-166 μg g day …
Michigan State UniversityMichigan State UniversityNational Chung-Hsing UniversityNational Chung-Hsing UniversityUnited States Department of Agriculture Agricultural Research Service (USDA)United States Department of Agriculture Agricultural Research Service (USDA)Purdue UniversityPurdue UniversityCornell UniversityCornell University
Publication
ID31059994Published Date2019-09-15JournalEcotoxicology and environmental safety, 2019-09-15, Volume 179
The majority of ecotoxicological studies performed measure average responses from individuals which do not account for the inter-individual variation in the responses of animals to environmental stimuli (i.e. the personality of individuals). Thus, these designs assume that all individuals will respond to contaminant exposure in a similar manner. Additionally, commonly used constant, static exposure regime designs neglect to recognize the spatial and temporal variation in contaminant plume str…
Alexandra N Steele Paul A Moore
University of MichiganUniversity of MichiganBowling Green State UniversityBowling Green State University
Publication
ID31233711Published Date2019-09-15JournalAnalytical biochemistry, 2019-09-15, Volume 581
A previous approach was established that allowed direct identification of pyridoxal-5'-phosphate (PLP) bonding sites in proteins using mass spectrometry after tryptic proteolysis. The approach required peptide mass fingerprinting owing to suppressed amide backbone fragmentation in favor of side-chain elimination of diagnostic product ions from PLP-derivatized lysyl residues. While sufficient for purified proteins, unambiguous sequence determination is needed to assign PLP bonding sites in unk…
Research Grant
Award Number1935265Funding AgencyNational Science FoundationEffective Date2019-09-15Expiration Date2023-08-31Funding Amount$1,367,717
Building synthetic cells is an exciting area of synthetic biology with opportunities to unravel basic design and organizational principles of cellular life. Dr. Liu and his collaborative team have identified the neuron as a potentially tractable cell to construct from the ground (bottom) up. Neurons convert biochemical signals to electrical dynamics and back to biochemical signals in animals. This project aims to construct a synthetic neuron with a modular design and a programmable synthetic …
Research Grant
Award Number1935047Funding AgencyNational Science FoundationEffective Date2019-09-15Expiration Date2022-08-31Funding Amount$712,698
This project seeks to build functional, lipid-free, 'living' cells by using proteins to create multi-compartment 'ProteoCells' that can self-generate, house reactions to produce products, interact with other ProteoCells, and in total, define a new type of cell-like structure with fundamentally novel properties. Cells are the most basic unit defining living systems, yet despite years of study, it remains unclear why nature chose to use lipids as its hallmark compartment-formers, and how compar…
Publication
ID31129330Published Date2019-09-15JournalThe Science of the total environment, 2019-09-15, Volume 683
The existence of lowland ponds alter watershed nitrogen (N) cycles via combined changes in runoff and N processing potential, which can significantly buffer watershed N transport. Here, we adopt the conceptual framework of the SPAtially Referenced Regressions On Watershed attributes (SPARROW) model to describe N transport and explore the buffering roles of lowland ponds in a small headwater watershed of Taihu Lake Basin, China. Our model, which included variables for nutrient sources, riverin…
Wangshou Zhang Hengpeng Li Anthony D Kendall David W Hyndman Yaqin Diaoshow 2 more
Chinese Academy of SciencesChinese Academy of SciencesMichigan State UniversityMichigan State University
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