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University (270K)Research Institution (18.8K)Hospital (17.3K)Company (4.9K)Foundation (2.3K)Other (2.2K)organization (492)Investor (55)
1 - 10 of 270,097
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Publication
ID30955488Published Date2019-05-27JournalPhilosophical transactions of the Royal Society of London. Series B, Biological sciences, 2019-05-27, Volume 374
Incidence of human papillomavirus (HPV) related cancers is increasing, generating substantial interest in understanding how trends in population prevalence of HPV infection are changing. However, there are no direct, population-scale measurements of HPV prevalence prior to 2003. Previous work using models to reconstruct historical trends have focused only on genital infection or seroprevalence (prevalence of antibodies) separately, and the results of these single-measure studies have been har…
Publication
ID30784796Published Date2019-05-30JournalEcotoxicology and environmental safety, 2019-05-30, Volume 173
Microplastics can have strong sorption capacity for many contaminants, thus greatly influencing the fate, transport and bioavailability of those contaminants in the environment. However, the effect of particle size on contaminant sorption by microplastics is still poorly understood. This study investigated the sorption of phenanthrene and nitrobenzene to micron-, submicron- and nano- sized polystyrene microplastics of 170 µm, 102 µm, 50 µm, 30 µm, 800 nm, 235 nm or 50 nm. All phenanthrene sor…
Juan Wang Xinhui Liu Guannan Liu Zixuan Zhang Hao Wushow 3 more
Beijing Normal University (BNU)Beijing Normal University (BNU)Dongguan University of TechnologyDongguan University of TechnologyMichigan State UniversityMichigan State University
Publication
ID30880166Published Date2019-05-30JournalJournal of proteomics, 2019-05-30, Volume 200
Despite data-independent acquisition (DIA) has been increasingly used for relative protein quantification, DIA-based label-free absolute quantification method has not been fully established. Here we present a novel DIA method using the TPA algorithm (DIA-TPA) for the absolute quantification of protein expressions in human liver microsomal and S9 samples. To validate this method, both data-dependent acquisition (DDA) and DIA experiments were conducted on 36 individual human liver microsome and…
Publication
ID30851550Published Date2019-05-21JournalJournal of theoretical biology, 2019-05-21, Volume 469
According to the World Health Organization, tuberculosis (TB) is the leading cause of death from infectious disease worldwide (WHO, 2017). While there is no effective vaccine against adult pulmonary TB, more than a dozen vaccine candidates are in the clinical trial pipeline. These include both pre-exposure vaccines to prevent initial infections and post-exposure vaccines to prevent reactivation of latent disease. Many epidemiological models have been used to study TB, but most have not includ…
Publication
ID30609113Published Date2019-05-20JournalStatistics in medicine, 2019-05-20, Volume 38
Center-specific survival outcomes of kidney transplant recipients are an important quality measure, with several challenges. Existing methods based on restricted mean lifetime tend to focus on short- and medium-term clinical outcomes and may fail to capture long-term effects associated with quality of follow-up care. In this report, we propose methods that combine a lognormal frailty model and piecewise exponential baseline rates to compare the mean survival time across centers. The proposed …
Publication
ID30663113Published Date2019-05-20JournalStatistics in medicine, 2019-05-20, Volume 38
The last two decades have witnessed an explosion in research focused on the development and assessment of novel biomarkers for improved prognosis of diseases. As a result, best practice standards guiding biomarker research have undergone extensive development. Currently, there is great interest in the promise of biomarkers to enhance research efforts and clinical practice in the setting of chronic kidney disease, acute kidney injury, and glomerular disease. However, some have questioned wheth…
Michael J Pencina Chirag R Parikh P L Kimmel Nancy R Cook Josef Coreshshow 10 more
Duke Clinical Research InstituteDuke Clinical Research InstituteDuke UniversityDuke UniversityJohns Hopkins UniversityJohns Hopkins UniversityNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)National Institutes of Health (NIH)National Institutes of Health (NIH)show 12 more
Research Grant
Award Number1849638Funding AgencyNational Science FoundationEffective Date2019-06-01Expiration Date2021-05-31Funding Amount$358,287
This collaborative research project in the history of science will produce the first full English translations of the commentaries and scholia to Aratus's literary work, Phaenomena, a popular text poem dealing with astronomy of Greek and Roman antiquity. It presented an accessible summary of star lore based upon a now lost work of Eudoxus, and it was an immediate and lasting success as an introductory text to astronomy; an immense exegetical literature grew up around it. This literature inclu…
Publication
ID30858016Published Date2019-06-01JournalNeurochemistry international, 2019-06-01, Volume 126
The neurovascular unit is composed of endothelial cells, vascular smooth muscle cells, pericytes, astrocytes and neurons. Through tightly regulated multi-directional cell signaling, the neurovascular unit is responsible for the numerous functionalities of the cerebrovasculature - including the regulation of molecular and cellular transport across the blood-brain barrier, angiogenesis, blood flow responses to brain activation and neuroinflammation. Historically, the study of the brain vasculat…
Ethan A Winkler Alex Y Lu Kunal P Raygor Joseph R Linzey Soren Jonzzonshow 3 more
University of California San Francisco (UCSF)University of California San Francisco (UCSF)University of California SystemUniversity of California SystemUniversity of MichiganUniversity of Michigan
Publication
ID30793790Published Date2019-06-01JournalMagnetic resonance in medicine, 2019-06-01, Volume 81
Anisotropic transverse R (1/T ) relaxation of water proton is sensitive to cartilage degenerative changes. The purpose is to develop an efficient method to extract this relaxation metric in clinical studies.Anisotropic R can be measured inefficiently by standard R mapping after removing an isotropic contribution obtained from R mapping. In the proposed method, named as a unique anisotropic R of collagen degeneration (ARCADE) mapping, an assumed uniform isotropic R was estimated at magic angle…
Clinical Trial
Clinical Trial IDNCT03381183Start Date2019-06-01Completion Date2021-06-01PhasePhase 1/Phase 2Study TypeInterventionalStatusNot yet recruiting
The purpose of this study is to see if the IRX-2 regimen, durvalumab, and tremelimumab will have a tolerable safety profile and will increase the intratumoral immune profile compared with the pretreatment tumors.
Christine H Chung Nabil F Saba
H. Lee Moffitt Cancer Center and Research InstituteH. Lee Moffitt Cancer Center and Research InstituteEmory UniversityEmory UniversityUniversity of MichiganUniversity of Michigan
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